Hypoxic Stress Facilitates Acute Activation and Chronic Downregulation of Fanconi Anemia Proteins
Scanlon SE, Glazer PM. Hypoxic Stress Facilitates Acute Activation and Chronic Downregulation of Fanconi Anemia Proteins. Molecular Cancer Research 2014, 12: 1016-1028. PMID: 24688021, PMCID: PMC4101147, DOI: 10.1158/1541-7786.mcr-13-0628.Peer-Reviewed Original ResearchConceptsFanconi anemia proteinsDNA repair pathwaysFA pathwayGenomic instabilityRepair pathwaysUbiquitination of FANCD2Intact FA pathwayATR-dependent mannerFA pathway activationAccumulation of γH2AXGenome integrityReplication stressTranscriptional repressionHypoxic conditionsFANCD2Cell survivalDNA damageHypoxic downregulationProtein downregulationHypoxic stressFANCIPathway activationPathwayKey membersCritical role