2023
The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression
Wei J, Alfajaro M, Cai W, Graziano V, Strine M, Filler R, Biering S, Sarnik S, Patel S, Menasche B, Compton S, Konermann S, Hsu P, Orchard R, Yan Q, Wilen C. The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression. PLOS Pathogens 2023, 19: e1011351. PMID: 37410700, PMCID: PMC10325096, DOI: 10.1371/journal.ppat.1011351.Peer-Reviewed Original ResearchConceptsMouse hepatitis virusReceptor expressionTherapeutic targetMERS-CoVMajor SARS-CoV-2 variantsPrimary human airwaySARS-CoV-2 variantsNovel therapeutic targetViral receptor expressionSARS-CoV-2Histone methyltransferase KMT2DIntestinal epithelial cellsCoronavirus SusceptibilityDiverse coronavirusesHistone demethylase KDM6ADPP4 expressionCoronavirus receptorsHost determinantsHepatitis virusHuman airwaysSARS-CoVSmall molecule inhibitionViral entryPotential drug targetsViral receptors
2022
Modeling pandemic to endemic patterns of SARS-CoV-2 transmission using parameters estimated from animal model data
Mullin S, Vander Wyk B, Asher JL, Compton SR, Allore HG, Zeiss CJ. Modeling pandemic to endemic patterns of SARS-CoV-2 transmission using parameters estimated from animal model data. PNAS Nexus 2022, 1: pgac096. PMID: 35799833, PMCID: PMC9254158, DOI: 10.1093/pnasnexus/pgac096.Peer-Reviewed Original ResearchSARS-CoV-2 transmissionNatural infectionDuration of immunitySARS-CoV-2 pandemicAnimal model dataEndemic stateHeterologous vaccinationMedian timeCoronaviral diseaseDeterministic compartmental modelNatural immunityLow prevalenceCoronaviral infectionVaccinationViral transmissionInfectionTransmissible variantsImmunityEndemic patternReinfection dataNatural exposureReinfectionEndemic stabilityVariable durationAnimals
2021
Modeling SARS-CoV-2 propagation using rat coronavirus-associated shedding and transmission
Zeiss CJ, Asher JL, Vander Wyk B, Allore HG, Compton SR. Modeling SARS-CoV-2 propagation using rat coronavirus-associated shedding and transmission. PLOS ONE 2021, 16: e0260038. PMID: 34813610, PMCID: PMC8610237, DOI: 10.1371/journal.pone.0260038.Peer-Reviewed Original ResearchConceptsViral sheddingSialodacryoadenitis virusSARS-CoV-2Prior natural infectionSARS-CoV-2 propagationSeropositive animalsLow-level sheddingNaive recipient ratsCOVID-19Cycle threshold valuesDirect contact exposureSeroconversion ratesReinfected animalsRecipient ratsImmune protectionHigh riskNaive animalsSusceptible individualsInitial infectionGlobal immunityExposure paradigmRat coronavirusNatural infectionInfectionRatsOverview of Coronaviruses in Veterinary Medicine.
Compton SR. Overview of Coronaviruses in Veterinary Medicine. Comparative Medicine 2021, 71: 333-341. PMID: 34412731, PMCID: PMC8594256, DOI: 10.30802/aalas-cm-21-000007.Peer-Reviewed Original ResearchAnimal Models of COVID-19. I. Comparative Virology and Disease Pathogenesis
Zeiss CJ, Compton S, Veenhuis RT. Animal Models of COVID-19. I. Comparative Virology and Disease Pathogenesis. ILAR Journal 2021, 62: ilab007-. PMID: 33836527, PMCID: PMC8083356, DOI: 10.1093/ilar/ilab007.Peer-Reviewed Original ResearchConceptsSARS-CoV-2SARS-CoVViral sheddingImmune responseSpontaneous modelAnimal modelsDisease pathogenesisSARS-CoV-2 infectionCOVID-19Severe acute respiratory syndrome coronavirusAcute respiratory syndrome coronavirusChimeric SARS-CoVRole of comorbiditiesCoronavirus disease 2019 (COVID-19) pandemicShort-term immune responseWild-type miceSeverity of diseaseOrgan-specific pathologySARS-CoV-2 virusDisease 2019 pandemicAfrican green monkeysTest therapeuticsVaccine approachesNonfatal diseaseTissue involvement
2020
Cutaneous and Pulmonary Mucormycosis in Rag1- and Il2rg-deficient Rats.
Sarfaty AE, Compton SR, Smith PC, Zeiss CJ. Cutaneous and Pulmonary Mucormycosis in Rag1- and Il2rg-deficient Rats. Comparative Medicine 2020, 70: 390-395. PMID: 32736665, PMCID: PMC7446636, DOI: 10.30802/aalas-cm-20-000015.Peer-Reviewed Original ResearchPCR and RT-PCR in the Diagnosis of Laboratory Animal Infections and in Health Monitoring.
Compton SR. PCR and RT-PCR in the Diagnosis of Laboratory Animal Infections and in Health Monitoring. Journal Of The American Association For Laboratory Animal Science 2020, 59: 458-468. PMID: 32580820, PMCID: PMC7479767, DOI: 10.30802/aalas-jaalas-20-000008.Peer-Reviewed Original Research
2019
Transverse myelitis following measles vaccination in a rhesus macaque (Macaca mulatta)
Sarfaty AE, Fulbright RK, Compton SR, Asher JL, Zeiss CJ. Transverse myelitis following measles vaccination in a rhesus macaque (Macaca mulatta). Journal Of Medical Primatology 2019, 49: 103-106. PMID: 31789460, DOI: 10.1111/jmp.12453.Peer-Reviewed Original ResearchChapter 13 Viral Disease
Macy J, Compton S. Chapter 13 Viral Disease. 2019, 541-568. PMCID: PMC7153344, DOI: 10.1016/b978-0-12-814338-4.00013-1.Peer-Reviewed Original Research
2017
Lack of Effect of Murine Astrovirus Infection on Dextran Sulfate-induced Colitis in NLRP3-deficient Mice.
Compton SR, Booth CJ, Macy JD. Lack of Effect of Murine Astrovirus Infection on Dextran Sulfate-induced Colitis in NLRP3-deficient Mice. Comparative Medicine 2017, 67: 400-406. PMID: 28935001, PMCID: PMC5621567.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstroviridaeAstroviridae InfectionsColitisColonDextran SulfateDisease Models, AnimalFemaleGastrointestinal MicrobiomeInflammasomesMaleMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinRandom AllocationReal-Time Polymerase Chain ReactionReproducibility of ResultsRodent DiseasesRodentiaConceptsColitis modelInflammatory bowel disease researchNOD-like receptor 3Induced colitis modelSeverity of colitisDextran sodium sulfateDSS colitis modelNLRP3-deficient miceDefective inflammasome activationLack of effectMucosal ulcerationIntestinal inflammationHistopathologic changesIntestinal permeabilityAstrovirus infectionFemale miceClinical signsDeficient miceNLRP3 mutationsClinical diseaseInflammasome activationGastrointestinal tractMurine astrovirusIntestinal bacteriaIntestinal epitheliumMurine Astrovirus Infection and Transmission in Neonatal CD1 Mice.
Compton SR, Booth CJ, Macy JD. Murine Astrovirus Infection and Transmission in Neonatal CD1 Mice. Journal Of The American Association For Laboratory Animal Science 2017, 56: 402-411. PMID: 28724490, PMCID: PMC5517330.Peer-Reviewed Original Research
2015
Effect of Cage-Wash Temperature on the Removal of Infectious Agents from Caging and the Detection of Infectious Agents on the Filters of Animal Bedding-Disposal Cabinets by PCR Analysis.
Compton SR, Macy JD. Effect of Cage-Wash Temperature on the Removal of Infectious Agents from Caging and the Detection of Infectious Agents on the Filters of Animal Bedding-Disposal Cabinets by PCR Analysis. Journal Of The American Association For Laboratory Animal Science 2015, 54: 745-55. PMID: 26632784, PMCID: PMC4671790.Peer-Reviewed Original ResearchConceptsMouse hepatitis virusMouse parvovirusMyocoptes musculinusInfectious agentsS. obvelataDetection of infectionHepatitis virusPCR analysisHousing micePathogen transmissionFacility levelMiceCages housing miceHelicobacter sppM. pulmonisSyphacia obvelataMycoplasma pulmonisCage washingParvovirusAnimal facilitiesSentinelsVirusAgentsPulmonisPathogen screening
2013
Immune Regulation and Oxidative Stress Reduction by Preimplantation Factor following Syngeneic or Allogeneic Bone Marrow Transplantation
Shainer R, Azar Y, Almogi-Hazan O, Bringer R, Compton S, Paidas M, Barnea E, Or R. Immune Regulation and Oxidative Stress Reduction by Preimplantation Factor following Syngeneic or Allogeneic Bone Marrow Transplantation. Conference Papers In Science 2013, 2013: 1-8. DOI: 10.1155/2013/718031.Peer-Reviewed Original ResearchBone marrow transplantationMarrow transplantationImmune responseAllogeneic bone marrow transplantationSyngeneic bone marrow transplantationAllogenic bone marrow transplantationImmune regulatory effectsProinflammatory gene expressionINOS gene expressionOxidative stress reductionImmune restorationPreImplantation FactorHost diseaseColon inflammationTransplant acceptanceINOS expressionSystemic immunityImmune regulationGene expressionMurine modelHematological diseasesWeight recoveryTransplantationOxidative stressTransplant successEffect of immunodeficiency on MPV shedding and transmission.
Macy JD, Paturzo FX, Compton SR. Effect of immunodeficiency on MPV shedding and transmission. Journal Of The American Association For Laboratory Animal Science 2013, 52: 467-74. PMID: 23849445, PMCID: PMC3725932.Peer-Reviewed Original Research
2012
Transmission of mouse parvovirus by fomites.
Compton SR, Paturzo FX, Smith PC, Macy JD. Transmission of mouse parvovirus by fomites. Journal Of The American Association For Laboratory Animal Science 2012, 51: 775-80. PMID: 23294883, PMCID: PMC3508181.Peer-Reviewed Original ResearchTransmission of mouse parvovirus to neonatal mice.
Compton SR, Paturzo FX, Macy JD. Transmission of mouse parvovirus to neonatal mice. Journal Of The American Association For Laboratory Animal Science 2012, 51: 797-802. PMID: 23294886, PMCID: PMC3508184.Peer-Reviewed Original ResearchAge-associated variability in susceptibility of Swiss Webster mice to MPV and other excluded murine pathogens.
Grove KA, Smith PC, Booth CJ, Compton SR. Age-associated variability in susceptibility of Swiss Webster mice to MPV and other excluded murine pathogens. Journal Of The American Association For Laboratory Animal Science 2012, 51: 789-96. PMID: 23294885, PMCID: PMC3508183.Peer-Reviewed Original ResearchConceptsSwiss Webster miceSoiled-bedding sentinelsInfectious agentsMouse parvovirusWebster miceMurine pathogenHealth surveillance protocolsAge-associated variabilityMode of transmissionContact sentinelsIndex miceSentinel miceMice ageHealth surveillanceMiceLocal pet storesMurine coloniesHost susceptibilityResearch colonyAgeSentinelsAgentsSusceptibilityPet storesPathogens
1998
Interactions of Enterotropic Mouse Hepatitis Viruses with Bgp2 Receptor Proteins
Compton S. Interactions of Enterotropic Mouse Hepatitis Viruses with Bgp2 Receptor Proteins. Advances In Experimental Medicine And Biology 1998, 440: 25-31. PMID: 9782261, DOI: 10.1007/978-1-4615-5331-1_4.Peer-Reviewed Original ResearchConceptsCMT93 cellsReceptor geneEnterotropic mouse hepatitis virus infectionMouse hepatitis virus infectionHepatitis virus infectionMHV-A59 infectionLimited tissue tropismCell receptor interactionsMHV infectionNeonatal miceVirus infectionIntestinal mucosaReceptor mRNAMouse hepatitisBHK cellsReceptor isoformsUnidentified receptorInfectionMonoclonal antibodiesTissue tropismVero cellsReceptor interactionRI useReceptor proteinReceptors
1996
Growth characteristics and protein profiles of prototype and wild-type rat coronavirus isolates grown in a cloned subline of mouse fibroblasts (L2p.176 cells)
Gaertner D, Compton S, Winograd D, Smith A. Growth characteristics and protein profiles of prototype and wild-type rat coronavirus isolates grown in a cloned subline of mouse fibroblasts (L2p.176 cells). Virus Research 1996, 41: 55-68. PMID: 8725102, PMCID: PMC7134090, DOI: 10.1016/0168-1702(95)01274-5.Peer-Reviewed Original Research
1995
Molecular characterization of the S proteins of two enterotropic murine coronavirus strains
Kunita S, Zhang L, Homberger F, Compton S. Molecular characterization of the S proteins of two enterotropic murine coronavirus strains. Virus Research 1995, 35: 277-289. PMID: 7785316, PMCID: PMC7134003, DOI: 10.1016/0168-1702(94)00089-u.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodies, ViralBase SequenceCapsidCell LineCloning, MolecularCoronavirus M ProteinsDNA, ViralImmunoblottingMembrane GlycoproteinsMiceMolecular Sequence DataMurine hepatitis virusSequence Homology, Amino AcidSpike Glycoprotein, CoronavirusViral Core ProteinsViral Envelope ProteinsViral Matrix ProteinsVirionConceptsMHV-RIS proteinAmino acid long proteinViral proteinsMurine coronavirusProtein-specific antiserumDifferent amino acid changesAmino acid changesLong proteinInefficient cleavageMolecular characterizationAcid changesCleavage siteAmino acidsProteinS geneMHV strainsHomologyM proteinEnterotropismRespiratory strainsGenesMinor differencesMHVStrains