Correction of Hyperinsulinemia by Glyburide Treatment in Nondiabetic Patients with Thalassemia Major
Jones T, Boulware S, Caprio S, Merkel P, Amiel S, Pearson H, Sherwin R, Tamborlane W. Correction of Hyperinsulinemia by Glyburide Treatment in Nondiabetic Patients with Thalassemia Major. Pediatric Research 1993, 33: 497-500. PMID: 8511023, DOI: 10.1203/00006450-199305000-00015.Peer-Reviewed Original ResearchConceptsDevelopment of diabetesGlyburide therapyInsulin responseNondiabetic patientsOral glucoseThalassemia majorInsulin-stimulated glucose metabolismCorrection of hyperinsulinemiaOral hypoglycemic agentsPlasma insulin responseEarly metabolic defectsEuglycemic insulin clampLow-dose treatmentPlasma glucose responseSecond-generation oral hypoglycemic agentsGlyburide treatmentInsulin hypersecretionInsulin clampInsulin resistanceHypoglycemic agentsThalassemic patientsM2/minGlucose metabolismPatientsGlucose response