1992
Effect of growth hormone treatment on hyperinsulinemia associated with turner syndrome
Caprio S, Boulware S, Press M, Sherwin R, Rubin K, Carpenter T, Plewe G, Tamborlane W. Effect of growth hormone treatment on hyperinsulinemia associated with turner syndrome. The Journal Of Pediatrics 1992, 120: 238-243. PMID: 1735819, DOI: 10.1016/s0022-3476(05)80434-2.Peer-Reviewed Original ResearchConceptsControl subjectsGrowth hormoneTurner syndromeHyperinsulinemic responseInsulin responseHyperglycemic glucose clamp techniqueSecond-phase insulin responseInsulin-stimulated glucose metabolismGlucose-stimulated insulin responseMonths of therapyMonths of treatmentTotal cholesterol levelsExcessive insulin secretionGrowth hormone treatmentGlucose clamp techniqueGlucose clamp procedureHuman growth hormoneBlood pressureGlucose incrementGlycosylated hemoglobinInsulin resistancePlasma levelsCholesterol levelsClamp procedureHealthy children
1989
Increased insulin secretion in puberty: A compensatory response to reductions in insulin sensitivity
Caprio S, Plewe G, Diamond M, Simonson D, Boulware S, Sherwin R, Tamborlane W. Increased insulin secretion in puberty: A compensatory response to reductions in insulin sensitivity. The Journal Of Pediatrics 1989, 114: 963-967. PMID: 2524556, DOI: 10.1016/s0022-3476(89)80438-x.Peer-Reviewed Original ResearchConceptsInsulin secretionPlasma insulinInsulin sensitivityInsulin-like growth factor IC-peptide responseGlucose-stimulated insulin secretionC-peptide concentrationsExcessive insulin secretionHyperglycemic clamp techniqueGlucose clamp procedureGrowth factor IGlucose incrementClamp procedureHealthy childrenPlasma levelsInsulin responseHyperglycemic stimulusClamp techniqueInsulin actionFactor INormal adultsNormal childrenCompensatory responseInsulinPuberty