2024
Persistent and multiclonal malaria parasite dynamics despite extended artemether-lumefantrine treatment in children
Goodwin J, Kajubi R, Wang K, Li F, Wade M, Orukan F, Huang L, Whalen M, Aweeka F, Mwebaza N, Parikh S. Persistent and multiclonal malaria parasite dynamics despite extended artemether-lumefantrine treatment in children. Nature Communications 2024, 15: 3817. PMID: 38714692, PMCID: PMC11076639, DOI: 10.1038/s41467-024-48210-7.Peer-Reviewed Original ResearchConceptsDay 7 lumefantrine concentrationsArtemether-lumefantrine treatmentRing-stage parasitesEarly post-treatmentEarly post-treatment periodArtemether-lumefantrineArtemisinin resistanceDay regimenMulticlonal infectionsEfficacious therapyFollow-upRandomized trialsPersistent clonesTransmission settingsEffective treatmentPost-treatment periodRegimensAntimalarial studiesStandard diagnosticsStandard 3DaysPost-treatmentChildrenTreatmentTherapy
2009
Intermittent Preventive Therapy for Malaria in Pregnancy: Is Sulfadoxine–Pyrimethamine the Right Drug?
Parikh S, Rosenthal PJ. Intermittent Preventive Therapy for Malaria in Pregnancy: Is Sulfadoxine–Pyrimethamine the Right Drug? Clinical Pharmacology & Therapeutics 2009, 87: 160-162. PMID: 20107451, DOI: 10.1038/clpt.2009.284.Peer-Reviewed Original Research
2005
Antimalarial Activity of Human Immunodeficiency Virus Type 1 Protease Inhibitors
Parikh S, Gut J, Istvan E, Goldberg DE, Havlir DV, Rosenthal PJ. Antimalarial Activity of Human Immunodeficiency Virus Type 1 Protease Inhibitors. Antimicrobial Agents And Chemotherapy 2005, 49: 2983-2985. PMID: 15980379, PMCID: PMC1168637, DOI: 10.1128/aac.49.7.2983-2985.2005.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type 1Protease inhibitorsHuman immunodeficiency virus type 1 (HIV-1) protease inhibitorsImmunodeficiency virus type 1HIV-1 protease inhibitorsVirus type 1Antimalarial activityCultured Plasmodium falciparumDevelopment of parasitesLopinavir therapyType 1Malaria parasitesPlasmodium falciparumLopinavirRelevant concentrationsInhibitorsPotent compoundsSimilar concentrationsParasitesRitonavirTherapyActivityFalciparum