Biochemical and immunological mechanisms by which sickle cell trait protects against malaria
Gong L, Parikh S, Rosenthal PJ, Greenhouse B. Biochemical and immunological mechanisms by which sickle cell trait protects against malaria. Malaria Journal 2013, 12: 317. PMID: 24025776, PMCID: PMC3847285, DOI: 10.1186/1475-2875-12-317.Peer-Reviewed Original ResearchConceptsSickle cell traitCell traitImmune-mediated mechanismsHost immune systemFalciparum malariaImmunological mechanismsProtective effectHO-1Immune componentsMultiple complex mechanismsImmune systemMalariaObserved protectionGenetic polymorphismsHost-parasite relationshipMicro RNAsNovel mechanismRelevant mechanismsDiseaseComplex mechanismsParasitic growth