2024
Persistent and multiclonal malaria parasite dynamics despite extended artemether-lumefantrine treatment in children
Goodwin J, Kajubi R, Wang K, Li F, Wade M, Orukan F, Huang L, Whalen M, Aweeka F, Mwebaza N, Parikh S. Persistent and multiclonal malaria parasite dynamics despite extended artemether-lumefantrine treatment in children. Nature Communications 2024, 15: 3817. PMID: 38714692, PMCID: PMC11076639, DOI: 10.1038/s41467-024-48210-7.Peer-Reviewed Original ResearchConceptsDay 7 lumefantrine concentrationsArtemether-lumefantrine treatmentRing-stage parasitesEarly post-treatmentEarly post-treatment periodArtemether-lumefantrineArtemisinin resistanceDay regimenMulticlonal infectionsEfficacious therapyFollow-upRandomized trialsPersistent clonesTransmission settingsEffective treatmentPost-treatment periodRegimensAntimalarial studiesStandard diagnosticsStandard 3DaysPost-treatmentChildrenTreatmentTherapy
2017
Modelling the impact of antimalarial quality on the transmission of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum
Brock AR, Ross JV, Greenhalgh S, Durham DP, Galvani A, Parikh S, Esterman A. Modelling the impact of antimalarial quality on the transmission of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum. Infectious Disease Modelling 2017, 2: 161-187. PMID: 29928735, PMCID: PMC6001968, DOI: 10.1016/j.idm.2017.04.001.Peer-Reviewed Original ResearchAntimalarial usePoor-quality antimalarial medicinesAntimalarial medicinesSulfadoxine-pyrimethamine resistanceDrug-resistant parasitesEradication of malariaHuman malaria casesAntimalarial qualitySP monotherapySubtherapeutic dosesTransmission of resistanceMalaria casesDeterministic compartmental modelEffective treatmentResistant parasitesSP resistanceElimination effortsMalaria controlPlasmodium falciparumMonotherapyMedicine qualityPoor qualityTreatmentMedicineCompartmental model