2022
Neglecting the neglected during the COVID-19 pandemic: the case of leptospirosis in Sri Lanka
Warnasekara J, Agampodi S. Neglecting the neglected during the COVID-19 pandemic: the case of leptospirosis in Sri Lanka. Epidemiology And Health 2022, 44: e2022015. PMID: 35038829, PMCID: PMC9117097, DOI: 10.4178/epih.e2022015.Peer-Reviewed Original ResearchConceptsCOVID-19 pandemicCoronavirus disease 2019 (COVID-19) pandemicPublic health surveillance systemsCases of leptospirosisControl of leptospirosisDisease 2019 pandemicHealth surveillance systemsGlobal health systemLarge outbreakInfectious diseasesHealth systemLeptospirosisTransmission dynamicsSurveillance systemPandemicSurveillanceSri LankaDisease
2019
An outbreak of leptospirosis with predominant cardiac involvement: a case series
Jayathilaka PGNS, Mendis ASV, Perera MHMTS, Damsiri HMT, Gunaratne AVC, Agampodi SB. An outbreak of leptospirosis with predominant cardiac involvement: a case series. BMC Infectious Diseases 2019, 19: 265. PMID: 30885170, PMCID: PMC6423826, DOI: 10.1186/s12879-019-3905-7.Peer-Reviewed Original ResearchConceptsColombo North Teaching HospitalCardiac involvementMulti-organ dysfunctionCase seriesSevere leptospirosisTeaching hospitalDynamic T-wave changesInotropic/vasopressor supportNon-specific clinical findingsEvidence of myocarditisPredominant cardiac involvementRapid atrial fibrillationSingle medical wardAcute kidney injuryMean arterial pressureStudy of patientsCourse of illnessT-wave changesCase presentationWe reportOutbreak of leptospirosisPossible leptospirosisResidual complicationsVasopressor supportKidney injuryCommon complication
2016
Is Sri Lanka prepared for yellow fever outbreaks? A case study
Wickramage K, Agampodi SB, Mosca D, Peiris S. Is Sri Lanka prepared for yellow fever outbreaks? A case study. The Lancet Global Health 2016, 4: e909-e910. PMID: 27855869, DOI: 10.1016/s2214-109x(16)30309-6.Peer-Reviewed Original ResearchSevere leptospirosis and pancreatitis; A case series from a leptospirosis outbreak in Anuradhapura district, Sri Lanka
Herath NJ, Kamburapola CJ, Agampodi SB. Severe leptospirosis and pancreatitis; A case series from a leptospirosis outbreak in Anuradhapura district, Sri Lanka. BMC Infectious Diseases 2016, 16: 644. PMID: 27821124, PMCID: PMC5100107, DOI: 10.1186/s12879-016-2010-4.Peer-Reviewed Original ResearchConceptsIntensive care unitSevere leptospirosisCase seriesConclusionThis case seriesResidual organ damageAcute kidney injuryLow serum calciumAnuradhapura districtBackgroundAcute pancreatitisAbdominal painKidney injurySix patientsCommon complicationCare unitClinical presentationElevated amylaseOrgan damageRare presentationSerum calciumAcute pancreatitisCase presentationWeNeutrophilic leukocytosisMain complicationsSerum amylaseTeaching hospitalRedefining Gold Standard Testing for Diagnosing Leptospirosis: Further Evidence from a Well-Characterized, Flood-Related Outbreak in Sri Lanka.
Agampodi SB, Dahanayaka NJ, Nöckler K, Mayer-Scholl A, Vinetz JM. Redefining Gold Standard Testing for Diagnosing Leptospirosis: Further Evidence from a Well-Characterized, Flood-Related Outbreak in Sri Lanka. American Journal Of Tropical Medicine And Hygiene 2016, 95: 531-536. PMID: 27402521, PMCID: PMC5014254, DOI: 10.4269/ajtmh.16-0033.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayMicroscopic agglutination testIgG enzyme-linked immunosorbent assayQuantitative polymerase chain reactionImmunoglobulin G (IgG) ELISAHouse enzyme-linked immunosorbent assayDays of illnessAcute-phase seraCases of leptospirosisAvailable enzyme-linked immunosorbent assayGold standard testingMAT positive samplesDiagnostic test resultsAcute specimensAcute phasePatient populationPhase seraPolymerase chain reactionBlood samplesSerological sensitivityAgglutination testImmunosorbent assayLeptospirosisLeptospira kirschneriDominant serovarsClinical Features and Transmission Pattern of Hepatitis A: An Experience from a Hepatitis A Outbreak Caused by Two Cocirculating Genotypes in Sri Lanka.
Dahanayaka NJ, Kiyohara T, Agampodi SB, Samaraweera PK, Kulasooriya GK, Ranasinghe JC, Semage SN, Yoshizaki S, Wakita T, Ishii K. Clinical Features and Transmission Pattern of Hepatitis A: An Experience from a Hepatitis A Outbreak Caused by Two Cocirculating Genotypes in Sri Lanka. American Journal Of Tropical Medicine And Hygiene 2016, 95: 908-914. PMID: 27382079, PMCID: PMC5062799, DOI: 10.4269/ajtmh.16-0221.Peer-Reviewed Original ResearchConceptsHepatitis A virusMost patientsHepatitis AHAV immunoglobulin MIntermediate endemic areaAcute viral hepatitisUpper abdominal discomfortHepatitis A outbreaksHigh-risk groupStrains of HAVMilitary personnelAcute hepatitisHAV vaccinationPale stoolsAbdominal discomfortViral hepatitisClinical featuresHepatitis outbreakSubgenotype IAClinical informationInfected personsPatientsA virusHepatitisSerial outbreaks
2015
The 2013 measles outbreak in Sri Lanka: experience from a rural district and implications for measles elimination goals
Dahanayaka NJ, Pahalagamage S, Ganegama RM, Weerawansa P, Agampodi SB. The 2013 measles outbreak in Sri Lanka: experience from a rural district and implications for measles elimination goals. Infectious Diseases Of Poverty 2015, 4: 51. PMID: 26627462, PMCID: PMC4667465, DOI: 10.1186/s40249-015-0084-7.Peer-Reviewed Original ResearchConceptsMeasles elimination goalElimination goalsMeasles immunization schedulePosterior cervical lymphadenopathyCommon clinical featuresIntensive care unitUniversity Medical UnitMonths of ageBasic demographic detailsCervical lymphadenopathyKoplik's spotsMaculopapular rashImmunization statusPrior immunizationVaccine scheduleCare unitClinical featuresImmunization scheduleMeasles vaccineSevere pneumoniaMeasles immunizationProspective studyRespiratory difficultyRubella vaccineEpidemiological profile
2014
Characteristics of Rural Leptospirosis Patients Admitted to Referral Hospitals During the 2008 Leptospirosis Outbreak in Sri Lanka: Implications for Developing Public Health Control Measures
Agampodi SB, Nugegoda DB, Thevanesam V, Vinetz JM. Characteristics of Rural Leptospirosis Patients Admitted to Referral Hospitals During the 2008 Leptospirosis Outbreak in Sri Lanka: Implications for Developing Public Health Control Measures. American Journal Of Tropical Medicine And Hygiene 2014, 92: 139-144. PMID: 25331809, PMCID: PMC4347370, DOI: 10.4269/ajtmh.14-0465.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesDisease OutbreaksHospitalsHumansLeptospirosisPublic HealthReferral and ConsultationRural PopulationSri LankaConceptsRisk factorsHospital-based case-control studyPublic health control measuresCase-control studyExposure risk factorsHealth control measuresFebrile patientsReferral hospitalCase patientsLeptospirosis patientsMean ageControl studyTropical settingsPatientsVicinity of homeLeptospirosis outbreaksDog ownershipIndividual exposureLeptospirosisMain predictorsDisease transmissionControl measuresMajor roleHospitalSettingGlobalization of leptospirosis through travel and migration
Bandara M, Ananda M, Wickramage K, Berger E, Agampodi S. Globalization of leptospirosis through travel and migration. Globalization And Health 2014, 10: 61. PMID: 25112368, PMCID: PMC4131158, DOI: 10.1186/s12992-014-0061-0.Peer-Reviewed Original ResearchMeSH KeywordsCommunicable Diseases, EmergingDisease OutbreaksEmigration and ImmigrationGlobal HealthHumansLeptospirosisRisk FactorsTravelConceptsMajor independent risk factorIndependent risk factorEpidemiology of leptospirosisWidespread zoonotic diseaseRisk factorsContribution of travelOccupational exposurePreventive strategiesHigh-income countriesEndemic countriesDisease acquisitionHealth professionalsTotal caseloadHealth systemLeptospirosisDiagnostic facilitiesDiseaseZoonotic diseaseInternational travelGlobal travelPrevious studiesLongitudinal dataClear increaseEpidemiologyDiagnosisRegional Differences of Leptospirosis in Sri Lanka: Observations from a Flood-Associated Outbreak in 2011
Agampodi SB, Dahanayaka NJ, Bandaranayaka AK, Perera M, Priyankara S, Weerawansa P, Matthias MA, Vinetz JM. Regional Differences of Leptospirosis in Sri Lanka: Observations from a Flood-Associated Outbreak in 2011. PLOS Neglected Tropical Diseases 2014, 8: e2626. PMID: 24454971, PMCID: PMC3894175, DOI: 10.1371/journal.pntd.0002626.Peer-Reviewed Original ResearchConceptsOutbreak of leptospirosisClinical presentationAcute renal failureDifferent clinical presentationsCross-sectional studyMedian bacterial loadPublic health interventionsPublic health relevanceLeptospira interrogans serovar laiRenal failureSevere thrombocytopeniaInfectious disease epidemicsDifferent Leptospira speciesEtiological causesImportant causeHealth interventionsHealth relevanceLeptospirosisTropical diseasesBacterial loadLeptospira kirschneriLeptospirosis outbreaksSerovar laiLeptospira speciesL. kirschneri
2013
Is There a Risk of Yellow Fever Virus Transmission in South Asian Countries with Hyperendemic Dengue?
Agampodi SB, Wickramage K. Is There a Risk of Yellow Fever Virus Transmission in South Asian Countries with Hyperendemic Dengue? BioMed Research International 2013, 2013: 905043. PMID: 24367789, PMCID: PMC3866876, DOI: 10.1155/2013/905043.Peer-Reviewed Original ResearchMeSH KeywordsAedesAnimalsAsiaDengueDengue VirusDisease OutbreaksHumansSri LankaYellow FeverYellow fever virusConceptsYellow feverYellow fever virus transmissionPublic health alertsAedes aegypti densityEndemic areasYF transmissionHealth authoritiesDengue burdenHealth alertsHealth officialsLocal transmissionVirus transmissionGlobal healthRiskMosquito densityLiterature pertainingActual riskSouth Asian countriesAsian countriesAegypti densityProbable riskSri LankaFeverPotential spreadOutbreak of leptospirosis after white-water rafting: sign of a shift from rural to recreational leptospirosis in Sri Lanka?
AGAMPODI SB, KARUNARATHNA D, JAYATHILALA N, RATHNAYAKA H, AGAMPODI TC, KARUNANAYAKA L. Outbreak of leptospirosis after white-water rafting: sign of a shift from rural to recreational leptospirosis in Sri Lanka? Epidemiology And Infection 2013, 142: 843-846. PMID: 23800619, PMCID: PMC9151153, DOI: 10.1017/s0950268813001465.Peer-Reviewed Original ResearchMeSH KeywordsAdultCommunicable Diseases, EmergingDisease OutbreaksFemaleHumansLeptospirosisMaleRecreationRiversSri LankaConceptsMAT titresPositive IgM ELISAClassical clinical featuresAnti-leptospiral antibodiesHistory of leptospirosisOutbreak of leptospirosisEpidemiology of leptospirosisAfebrile patientsClinical featuresAcute leptospirosisFever patientsIgM ELISAAffluent urban populationsOccupational hazardsOutbreak investigationLeptospirosisLeptospirosis outbreaksOffice workersPatientsTitresWeeksExposureParticipantsOutbreakRecreational activities
2012
Utility of Quantitative Polymerase Chain Reaction in Leptospirosis Diagnosis: Association of Level of Leptospiremia and Clinical Manifestations in Sri Lanka
Agampodi SB, Matthias MA, Moreno AC, Vinetz JM. Utility of Quantitative Polymerase Chain Reaction in Leptospirosis Diagnosis: Association of Level of Leptospiremia and Clinical Manifestations in Sri Lanka. Clinical Infectious Diseases 2012, 54: 1249-1255. PMID: 22354922, PMCID: PMC3404689, DOI: 10.1093/cid/cis035.Peer-Reviewed Original ResearchConceptsQuantitative polymerase chain reactionClinical manifestationsPolymerase chain reactionBlood samplesChain reactionWhole bloodOnset of symptomsSensitivity of qPCRAssociation of levelsSerum/bloodMicroscopic agglutination test panelValid diagnostic testPatient blood samplesOptimal sample typeFailure patientsRenal failureWhole blood samplesPatient populationTimely diagnosisLeptospiral loadEndemic areasDay 2Day 15LeptospiremiaDiagnostic tests
2011
Leptospirosis Outbreak in Sri Lanka in 2008: Lessons for Assessing the Global Burden of Disease
Agampodi SB, Peacock SJ, Thevanesam V, Nugegoda DB, Smythe L, Thaipadungpanit J, Craig SB, Burns MA, Dohnt M, Boonsilp S, Senaratne T, Kumara A, Palihawadana P, Perera S, Vinetz JM. Leptospirosis Outbreak in Sri Lanka in 2008: Lessons for Assessing the Global Burden of Disease. American Journal Of Tropical Medicine And Hygiene 2011, 85: 471-478. PMID: 21896807, PMCID: PMC3163869, DOI: 10.4269/ajtmh.2011.11-0276.Peer-Reviewed Original ResearchMeSH KeywordsDisease OutbreaksGlobal HealthHumansLeptospirosisOils, VolatilePhloroglucinolPhylogenyRNA, Ribosomal, 16SSri LankaConceptsAcute renal failureLeptospirosis outbreaksCase fatality rateLimited diagnostic capacityDisease burden estimatesLaboratory diagnostic capabilitiesEndemic infectious diseasesCause of epidemicSerovars PyrogenesClinical characteristicsRenal failureHeart failurePatient populationMain complicationsCase definitionBurden estimatesGlobal burdenCase confirmationHigh titersInfectious diseasesDiagnostic capacityHigh endemicityReference groupLeptospira interrogansDisease