Next-Generation Sequencing Analysis of Pathogenic Leptospira: A Way Forward for Understanding Infectious Disease Dynamics in Low/Middle-Income, Disease-Endemic Settings.
Agampodi SB, Vinetz JM. Next-Generation Sequencing Analysis of Pathogenic Leptospira: A Way Forward for Understanding Infectious Disease Dynamics in Low/Middle-Income, Disease-Endemic Settings. American Journal Of Tropical Medicine And Hygiene 2021, 104: 1625-1627. PMID: 33755589, PMCID: PMC8103479, DOI: 10.4269/ajtmh.20-1518.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEndemic DiseasesGenotypeHigh-Throughput Nucleotide SequencingHumansLeptospiraLeptospirosisPhylogenyPovertySequence Analysis, DNASerogroupZoonoses12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka
Jayasundara D, Senavirathna I, Warnasekara J, Gamage C, Siribaddana S, Kularatne SAM, Matthias M, Mariet JF, Picardeau M, Agampodi S, Vinetz J. 12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka. PLOS Neglected Tropical Diseases 2021, 15: e0009272. PMID: 33735202, PMCID: PMC8009393, DOI: 10.1371/journal.pntd.0009272.Peer-Reviewed Original ResearchConceptsClonal groupsAcute kidney injuryL. interrogansMajor clinical challengeGlobal disease threatsLeptospira speciesL. interrogans infectionKidney injuryLiver impairmentCardiovascular involvementL. borgpeterseniiClinical presentationProspective studyClinical severityClinical challengePathogenic Leptospira speciesAnnual epidemicsUbiquitous zoonotic diseaseNew serogroupEpidemiological contextZoonotic diseaseCulture isolationLeptospiral culturesL. weiliiLeptospira diversity