2021
12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka
Jayasundara D, Senavirathna I, Warnasekara J, Gamage C, Siribaddana S, Kularatne SAM, Matthias M, Mariet JF, Picardeau M, Agampodi S, Vinetz J. 12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka. PLOS Neglected Tropical Diseases 2021, 15: e0009272. PMID: 33735202, PMCID: PMC8009393, DOI: 10.1371/journal.pntd.0009272.Peer-Reviewed Original ResearchConceptsClonal groupsAcute kidney injuryL. interrogansMajor clinical challengeGlobal disease threatsLeptospira speciesL. interrogans infectionKidney injuryLiver impairmentCardiovascular involvementL. borgpeterseniiClinical presentationProspective studyClinical severityClinical challengePathogenic Leptospira speciesAnnual epidemicsUbiquitous zoonotic diseaseNew serogroupEpidemiological contextZoonotic diseaseCulture isolationLeptospiral culturesL. weiliiLeptospira diversity
2019
Sequel and therapeutic modalities of leptospirosis associated severe pulmonary haemorrhagic syndrome (SPHS); a Sri Lankan experience
Herath N, Uluwattage W, Weliwitiya T, Karunanayake L, Lekamwasam S, Ratnatunga N, Karunanayake P, Wickramasinghe S, Patabendi S, Senaviratne S, Agampodi S. Sequel and therapeutic modalities of leptospirosis associated severe pulmonary haemorrhagic syndrome (SPHS); a Sri Lankan experience. BMC Infectious Diseases 2019, 19: 451. PMID: 31113404, PMCID: PMC6530063, DOI: 10.1186/s12879-019-4094-0.Peer-Reviewed Original ResearchConceptsTeaching Hospital KarapitiyaTherapeutic plasma exchangeAcute kidney injuryMain tertiary care centerSevere pulmonary hemorrhagic syndromeTertiary care centerDay of admissionGroup of patientsHigh case fatalityCase fatality rateCases of leptospirosisDifferent therapeutic approachesAlveolar shadowsHospital KarapitiyaHemoglobin dropKidney injuryArterial hypoxemiaCase fatalityPlasma exchangePatient presentingTreatment modalitiesCare centerHemorrhagic syndromeChest radiographsClinical diseaseAn outbreak of leptospirosis with predominant cardiac involvement: a case series
Jayathilaka PGNS, Mendis ASV, Perera MHMTS, Damsiri HMT, Gunaratne AVC, Agampodi SB. An outbreak of leptospirosis with predominant cardiac involvement: a case series. BMC Infectious Diseases 2019, 19: 265. PMID: 30885170, PMCID: PMC6423826, DOI: 10.1186/s12879-019-3905-7.Peer-Reviewed Original ResearchConceptsColombo North Teaching HospitalCardiac involvementMulti-organ dysfunctionCase seriesSevere leptospirosisTeaching hospitalDynamic T-wave changesInotropic/vasopressor supportNon-specific clinical findingsEvidence of myocarditisPredominant cardiac involvementRapid atrial fibrillationSingle medical wardAcute kidney injuryMean arterial pressureStudy of patientsCourse of illnessT-wave changesCase presentationWe reportOutbreak of leptospirosisPossible leptospirosisResidual complicationsVasopressor supportKidney injuryCommon complication
2016
Severe leptospirosis and pancreatitis; A case series from a leptospirosis outbreak in Anuradhapura district, Sri Lanka
Herath NJ, Kamburapola CJ, Agampodi SB. Severe leptospirosis and pancreatitis; A case series from a leptospirosis outbreak in Anuradhapura district, Sri Lanka. BMC Infectious Diseases 2016, 16: 644. PMID: 27821124, PMCID: PMC5100107, DOI: 10.1186/s12879-016-2010-4.Peer-Reviewed Original ResearchConceptsIntensive care unitSevere leptospirosisCase seriesConclusionThis case seriesResidual organ damageAcute kidney injuryLow serum calciumAnuradhapura districtBackgroundAcute pancreatitisAbdominal painKidney injurySix patientsCommon complicationCare unitClinical presentationElevated amylaseOrgan damageRare presentationSerum calciumAcute pancreatitisCase presentationWeNeutrophilic leukocytosisMain complicationsSerum amylaseTeaching hospital
2012
Predictors of the development of myocarditis or acute renal failure in patients with leptospirosis: An observational study
Dassanayake D, Wimalaratna H, Nandadewa D, Nugaliyadda A, Ratnatunga CN, Agampodi SB. Predictors of the development of myocarditis or acute renal failure in patients with leptospirosis: An observational study. BMC Infectious Diseases 2012, 12: 4. PMID: 22243770, PMCID: PMC3292442, DOI: 10.1186/1471-2334-12-4.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultAgglutination TestsFemaleHospitals, TeachingHumansLeptospirosisMaleMiddle AgedMyocarditisProspective StudiesSri LankaConceptsAcute renal failureRenal failureClinical featuresMicroscopic agglutination testOdds ratioTeaching hospitalExact testComplication of leptospirosisDevelopment of myocarditisLaboratory measuresCommon clinical featuresVaried clinical presentationsProspective descriptive studyPredictors of severityFisher's exact testMann-Whitney U testLogistic regression modelsPain 6ResultsSixty-twoLaboratory parametersClinical presentationLaboratory variablesLaboratory predictorsLeptospirosis patientsCase definition