2022
Diagnostic method-based underestimation of leptospirosis in clinical and research settings; an experience from a large prospective study in a high endemic setting
Warnasekara J, Srimantha S, Kappagoda C, Jayasundara D, Senevirathna I, Matthias M, Agampodi S, Vinetz J. Diagnostic method-based underestimation of leptospirosis in clinical and research settings; an experience from a large prospective study in a high endemic setting. PLOS Neglected Tropical Diseases 2022, 16: e0010331. PMID: 35377883, PMCID: PMC9009773, DOI: 10.1371/journal.pntd.0010331.Peer-Reviewed Original ResearchMeSH KeywordsAgglutination TestsHumansLeptospiraLeptospirosisProspective StudiesRetrospective StudiesConceptsMicroscopic agglutination testProspective hospital-based studyLeptospirosis casesQuantitative PCRHigh endemic settingHospital-based studyClinical case definitionLarge prospective studiesDisease burden estimatesPublic health burdenStandard diagnostic testMonths of observationUndifferentiated feverAcute leptospirosisProspective studyCase definitionEndemic settingsHealth burdenTimely diagnosisBurden estimatesDiagnostic valueSignificant human mortalityAgglutination testStudy settingDiagnostic tests
2021
Optimizing the microscopic agglutination test (MAT) panel for the diagnosis of Leptospirosis in a low resource, hyper-endemic setting with varied microgeographic variation in reactivity
Jayasundara D, Gamage C, Senavirathna I, Warnasekara J, Matthias MA, Vinetz J, Agampodi S. Optimizing the microscopic agglutination test (MAT) panel for the diagnosis of Leptospirosis in a low resource, hyper-endemic setting with varied microgeographic variation in reactivity. PLOS Neglected Tropical Diseases 2021, 15: e0009565. PMID: 34197457, PMCID: PMC8279374, DOI: 10.1371/journal.pntd.0009565.Peer-Reviewed Original Research
2016
Severe leptospirosis and pancreatitis; A case series from a leptospirosis outbreak in Anuradhapura district, Sri Lanka
Herath NJ, Kamburapola CJ, Agampodi SB. Severe leptospirosis and pancreatitis; A case series from a leptospirosis outbreak in Anuradhapura district, Sri Lanka. BMC Infectious Diseases 2016, 16: 644. PMID: 27821124, PMCID: PMC5100107, DOI: 10.1186/s12879-016-2010-4.Peer-Reviewed Original ResearchConceptsIntensive care unitSevere leptospirosisCase seriesConclusionThis case seriesResidual organ damageAcute kidney injuryLow serum calciumAnuradhapura districtBackgroundAcute pancreatitisAbdominal painKidney injurySix patientsCommon complicationCare unitClinical presentationElevated amylaseOrgan damageRare presentationSerum calciumAcute pancreatitisCase presentationWeNeutrophilic leukocytosisMain complicationsSerum amylaseTeaching hospital
2012
Utility of Quantitative Polymerase Chain Reaction in Leptospirosis Diagnosis: Association of Level of Leptospiremia and Clinical Manifestations in Sri Lanka
Agampodi SB, Matthias MA, Moreno AC, Vinetz JM. Utility of Quantitative Polymerase Chain Reaction in Leptospirosis Diagnosis: Association of Level of Leptospiremia and Clinical Manifestations in Sri Lanka. Clinical Infectious Diseases 2012, 54: 1249-1255. PMID: 22354922, PMCID: PMC3404689, DOI: 10.1093/cid/cis035.Peer-Reviewed Original ResearchConceptsQuantitative polymerase chain reactionClinical manifestationsPolymerase chain reactionBlood samplesChain reactionWhole bloodOnset of symptomsSensitivity of qPCRAssociation of levelsSerum/bloodMicroscopic agglutination test panelValid diagnostic testPatient blood samplesOptimal sample typeFailure patientsRenal failureWhole blood samplesPatient populationTimely diagnosisLeptospiral loadEndemic areasDay 2Day 15LeptospiremiaDiagnostic tests
2011
Duration of exclusive breastfeeding; validity of retrospective assessment at nine months of age
Agampodi SB, Fernando S, Dharmaratne SD, Agampodi TC. Duration of exclusive breastfeeding; validity of retrospective assessment at nine months of age. BMC Pediatrics 2011, 11: 80. PMID: 21917175, PMCID: PMC3189116, DOI: 10.1186/1471-2431-11-80.Peer-Reviewed Original ResearchMeSH KeywordsBreast FeedingData CollectionFemaleHumansInfantMaleMental RecallMothersReproducibility of ResultsRetrospective StudiesConceptsChild health development recordDuration of EBFExclusive breastfeedingRetrospective dataMaternal recallCohort studyEBF durationPregnancy recordsCessation of EBFMethodsA cohort studyMothers' recall dataRetrospective cohort studyProportion of infantsPublic health midwivesMother-infant pairsRecall dataMonths of ageBaseline data collectionStructured questionnaireMedian durationStudy cohortResultsA totalProspective dataSixth monthCase control
2010
Incidence and effects of Varicella Zoster Virus infection on academic activities of medical undergraduates - a five-year follow-up study from Sri Lanka
Agampodi SB, Dharmaratne SD, Thevanesam V, Dassanayake S, Kumarihamy P, Ratnayake A. Incidence and effects of Varicella Zoster Virus infection on academic activities of medical undergraduates - a five-year follow-up study from Sri Lanka. BMC Infectious Diseases 2010, 10: 117. PMID: 20465846, PMCID: PMC2882915, DOI: 10.1186/1471-2334-10-117.Peer-Reviewed Original ResearchConceptsVaricella-zoster virus infectionZoster virus infectionVZV infectionPerson yearsVirus infectionFive-year followNumber of infectionsSelf-administered structured questionnaireVZV immunizationConclusionsThe incidenceCumulative incidenceRetrospective cohortIncidence densityMedical undergraduatesStudy cohortIncidence rateClinical appointmentsAdult populationInfectionSusceptible cohortCohortIncidenceUniversity of PeradeniyaSecond questionnaireSri Lankan medical undergraduates