2024
Assessment of the productivity loss due to leading maternal ill-health conditions: a follow-up study of a prospective pregnancy cohort in rural Sri Lanka
Gunarathna S, Wickramasinghe N, Agampodi T, Prasanna I, Agampodi S. Assessment of the productivity loss due to leading maternal ill-health conditions: a follow-up study of a prospective pregnancy cohort in rural Sri Lanka. BMJ Open 2024, 14: e082798. PMID: 39477261, PMCID: PMC11529687, DOI: 10.1136/bmjopen-2023-082798.Peer-Reviewed Original ResearchConceptsIll-health conditionsRural Sri LankaPregnant womenPregnancy cohortFollow-up study of womenFollow-up studyProspective pregnancy cohortRajarata Pregnancy CohortSecondary outcome measuresMonthly household expenditureVaginal bleedingProductivity lossStudy of womenPrimary outcome measurePregnancy follow-upMedical careOutcome measuresHigher absenteeismNausea and vomitingPresenteeismHighest prevalenceAbsenteeismThird trimesterWomenRecommended priorities
2023
Early pregnancy metabolic syndrome and risk for adverse pregnancy outcomes: findings from Rajarata Pregnancy Cohort (RaPCo) in Sri Lanka
Jayasinghe I, Agampodi T, Dissanayake A, Agampodi S. Early pregnancy metabolic syndrome and risk for adverse pregnancy outcomes: findings from Rajarata Pregnancy Cohort (RaPCo) in Sri Lanka. BMC Pregnancy And Childbirth 2023, 23: 231. PMID: 37020187, PMCID: PMC10074348, DOI: 10.1186/s12884-023-05548-y.Peer-Reviewed Original ResearchConceptsGestational agePreterm birthPregnancy outcomesPregnant womenMetabolic syndromePregnancy cohortJoint Interim Statement criteriaFirst trimester pregnant womenMajor pregnancy outcomesSouth Asian pregnant womenAdverse pregnancy outcomesNeonatal birth weightGestational weight gainMedian gestational ageProspective cohort studyLive singleton birthsSignificant risk predictorAsian pregnant womenConclusionPregnant womenFPG thresholdMetS prevalenceCohort studyCumulative incidenceProspective cohortMetS definitionsDeterminants of birthweight in rural Sri Lanka; a cohort study
Banda P, Amarasinghe G, Agampodi S. Determinants of birthweight in rural Sri Lanka; a cohort study. BMC Pediatrics 2023, 23: 40. PMID: 36690991, PMCID: PMC9869565, DOI: 10.1186/s12887-022-03830-0.Peer-Reviewed Original ResearchMeSH KeywordsBirth WeightCohort StudiesFemaleHumansInfant, NewbornPregnancyPremature BirthProspective StudiesSri LankaConceptsMother-infant cohortPregnant womenCohort studyPreterm birthPsychosocial wellbeingThird trimester pregnant womenPerinatal health issuesProspective cohort studySocioeconomic statusPrimary care levelMaternal care servicesAntenatal care programsHusband's education levelSelf-completed questionnaireMiddle-income settingsEducation levelHierarchical logistic regressionPregnancy registrationHypertensive disordersMaternal BMISingleton pregnanciesThird trimesterBaby's sexChronic diabetesPerinatal health
2022
Culture-Independent Detection and Identification of Leptospira Serovars
Matthias M, Lubar A, Acharige S, Chaiboonma K, Pilau N, Marroquin A, Jayasundara D, Agampodi S, Vinetz J. Culture-Independent Detection and Identification of Leptospira Serovars. Microbiology Spectrum 2022, 10: e02475-22. PMID: 36445143, PMCID: PMC9769591, DOI: 10.1128/spectrum.02475-22.Peer-Reviewed Original ResearchConceptsPublic health importanceProspective studyFatal diseaseHealth importanceOutbreak investigationSequence typingDog urine samplesCulture-independent assaysEnvironmental surveillance studyMultilocus sequence typingPulsed-field gel electrophoresisSurveillance studyGroup IIHuman leptospirosisPrognostic testSpecific real-time qPCRClinical settingGroup ILeptospira serovarsReal-time qPCRDiagnostic testsSerum samplesUrine samplesDiagnostic specificityLeptospirosisAsthma in a prospective cohort of rural pregnant women from Sri Lanka: Need for better care during the pre-conceptional and antenatal period
Rajapakse S, Wickramasinghe N, Warnasekara J, Abeyrathna P, Amarasinghe G, Hettiarachchi AU, Jayasinghe IU, Koralegedara I, Agampodi TC, Agampodi SB. Asthma in a prospective cohort of rural pregnant women from Sri Lanka: Need for better care during the pre-conceptional and antenatal period. PLOS ONE 2022, 17: e0269888. PMID: 35834567, PMCID: PMC9282538, DOI: 10.1371/journal.pone.0269888.Peer-Reviewed Original ResearchMeSH KeywordsAsthmaCohort StudiesFemaleHumansPregnancyPregnancy OutcomePregnant WomenProspective StudiesSri LankaConceptsNew-onset wheezePregnant womenSecond trimesterAsthmatic womenPregnancy outcomesPregnant asthmatic womenEligible pregnant womenProspective cohort studyLow birth weightPrevalence of wheezeEffect of asthmaRural pregnant womenMaternal care programmeCohort studyProspective cohortHospital admissionAntenatal periodAsthma prevalenceFirst trimesterBirth weightClinical assessmentHigh prevalenceWheezeAsthmaTrimesterDiagnostic method-based underestimation of leptospirosis in clinical and research settings; an experience from a large prospective study in a high endemic setting
Warnasekara J, Srimantha S, Kappagoda C, Jayasundara D, Senevirathna I, Matthias M, Agampodi S, Vinetz J. Diagnostic method-based underestimation of leptospirosis in clinical and research settings; an experience from a large prospective study in a high endemic setting. PLOS Neglected Tropical Diseases 2022, 16: e0010331. PMID: 35377883, PMCID: PMC9009773, DOI: 10.1371/journal.pntd.0010331.Peer-Reviewed Original ResearchMeSH KeywordsAgglutination TestsHumansLeptospiraLeptospirosisProspective StudiesRetrospective StudiesConceptsMicroscopic agglutination testProspective hospital-based studyLeptospirosis casesQuantitative PCRHigh endemic settingHospital-based studyClinical case definitionLarge prospective studiesDisease burden estimatesPublic health burdenStandard diagnostic testMonths of observationUndifferentiated feverAcute leptospirosisProspective studyCase definitionEndemic settingsHealth burdenTimely diagnosisBurden estimatesDiagnostic valueSignificant human mortalityAgglutination testStudy settingDiagnostic testsNon-alcoholic fatty liver disease (NAFLD): a significant predictor of gestational diabetes mellitus (GDM) and early pregnancy miscarriages—prospective study in Rajarata Pregnancy Cohort (RaPCo)
Koralegedara IS, Warnasekara JN, Dayaratne KG, De Silva FN, Premadasa JK, Agampodi SB. Non-alcoholic fatty liver disease (NAFLD): a significant predictor of gestational diabetes mellitus (GDM) and early pregnancy miscarriages—prospective study in Rajarata Pregnancy Cohort (RaPCo). BMJ Open Gastroenterology 2022, 9: e000831. PMID: 35193889, PMCID: PMC8867246, DOI: 10.1136/bmjgast-2021-000831.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, SpontaneousCohort StudiesDiabetes, GestationalFemaleHumansNon-alcoholic Fatty Liver DiseasePregnancyProspective StudiesConceptsNon-alcoholic fatty liver diseaseGestational diabetes mellitusEarly pregnancy miscarriageFatty liver diseasePregnancy miscarriageRisk factorsDiabetes mellitusLiver diseasePregnant womenRelative riskEffect of NAFLDImpact of NAFLDPopulation-based prospective cohort studyRepeat oral glucose tolerance testFirst trimester pregnant womenOral glucose tolerance testPregnancy care programsProspective cohort studyOnly independent predictorBody mass indexGlucose tolerance testWeeks of gestationSignificant risk factorsMajor risk factorHigh-risk mothersEarly pregnancy hyperglycaemia as a significant predictor of large for gestational age neonates
Jayasinghe IU, Koralegedara IS, Agampodi SB. Early pregnancy hyperglycaemia as a significant predictor of large for gestational age neonates. Acta Diabetologica 2022, 59: 535-543. PMID: 34973071, PMCID: PMC8917036, DOI: 10.1007/s00592-021-01828-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultBirth WeightDiabetes, GestationalFemaleFetal MacrosomiaGestational AgeHumansHyperglycemiaInfantInfant, NewbornPregnancyProspective StudiesConceptsGestational diabetes mellitusGestational age neonatesLGA neonatesAge neonatesGestational ageFirst trimesterPrevalence of GDMWorld Health Organization criteriaDelivery gestational ageNeonatal birth weightPregnancy Study GroupsBirth weight centileMedian gestational ageProspective cohort studyAttributable risk percentageHigh-risk populationUndiagnosed DMCohort studyCumulative incidenceDiabetes mellitusWeight centileEarly pregnancyPregnant womenMean ageOrganization criteria
2021
Clinical spectrum of endemic leptospirosis in relation to cytokine response
Dahanayaka NJ, Agampodi SB, Seneviratna I, Warnasekara J, Rajapakse R, Ranathunga K, Matthias M, Vinetz JM. Clinical spectrum of endemic leptospirosis in relation to cytokine response. PLOS ONE 2021, 16: e0261025. PMID: 34879100, PMCID: PMC8654203, DOI: 10.1371/journal.pone.0261025.Peer-Reviewed Original ResearchConceptsCytokine responsesLeptospirosis patientsClinical spectrumHigher IL-13 levelsHigher IL-5Acute kidney injuryHigher serum creatinineIL-13 levelsSerum cytokine levelsIL-6 levelsUniversity Teaching HospitalMultiplex cytokine kitKidney injuryLung involvementCytokine levelsSerum creatinineAcute phaseCytokine kitIL-1βAcute samplesConvalescence periodIL-8IL-5Prognostic informationEndemic settings12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka
Jayasundara D, Senavirathna I, Warnasekara J, Gamage C, Siribaddana S, Kularatne SAM, Matthias M, Mariet JF, Picardeau M, Agampodi S, Vinetz J. 12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka. PLOS Neglected Tropical Diseases 2021, 15: e0009272. PMID: 33735202, PMCID: PMC8009393, DOI: 10.1371/journal.pntd.0009272.Peer-Reviewed Original ResearchConceptsClonal groupsAcute kidney injuryL. interrogansMajor clinical challengeGlobal disease threatsLeptospira speciesL. interrogans infectionKidney injuryLiver impairmentCardiovascular involvementL. borgpeterseniiClinical presentationProspective studyClinical severityClinical challengePathogenic Leptospira speciesAnnual epidemicsUbiquitous zoonotic diseaseNew serogroupEpidemiological contextZoonotic diseaseCulture isolationLeptospiral culturesL. weiliiLeptospira diversity
2020
The Rajarata Pregnancy Cohort (RaPCo): study protocol
Agampodi TC, Wickramasinghe ND, Prasanna RIR, Irangani MKL, Banda JMS, Jayathilake PMB, Hettiarachchi A, Amarasinghe G, Jayasinghe I, Koralagedara I, Gunarathne SP, Wickramage S, Warnasekara J, Lokunarangoda N, Mendis V, Dissanayaka AK, Premadasa J, Hettigama N, Koralagedara D, Weerasinghe M, Malawanage K, Jayakodi H, Wickramasinghe A, Agampodi SB. The Rajarata Pregnancy Cohort (RaPCo): study protocol. BMC Pregnancy And Childbirth 2020, 20: 374. PMID: 32586287, PMCID: PMC7318435, DOI: 10.1186/s12884-020-03056-x.Peer-Reviewed Original ResearchConceptsMaternal mental healthMaternal deathsMental healthSocial determinantsPregnancy cohortObstetric transitionEligible pregnant womenProspective cohort studyMaternal health outcomesMaternal mortality ratePreventable maternal deathsMaternal care programmeChild outcome dataAntenatal depressionCohort studyMiddle-income countriesFirst trimesterNeonatal periodPregnant womenClinical examinationMaternal healthEarly postpartumMaternal cohortStudy protocolMethodsThe studyEmerging pesticides responsible for suicide in rural Sri Lanka following the 2008–2014 pesticide bans
Weerasinghe M, Pearson M, Konradsen F, Agampodi S, Sumith JA, Jayamanne S, Senanayake SMHMK, Rajapaksha S, Eddleston M. Emerging pesticides responsible for suicide in rural Sri Lanka following the 2008–2014 pesticide bans. BMC Public Health 2020, 20: 780. PMID: 32450831, PMCID: PMC7249439, DOI: 10.1186/s12889-020-08871-7.Peer-Reviewed Original ResearchMeSH KeywordsAgricultureCarbamatesEatingGovernment RegulationHumansOrganothiophosphatesPesticidesProspective StudiesRural PopulationSri LankaSuicide
2019
Study protocol: characterising the clinical, epidemiological and aetiological aspects of leptospirosis in Sri Lanka: a hospital based clinico-epidemiological study
Agampodi S, Warnasekara J, Jayasundara D, Senawirathna I, Gamage C, Kularatne S, Siribaddana S, Maththias M, Vinetz J. Study protocol: characterising the clinical, epidemiological and aetiological aspects of leptospirosis in Sri Lanka: a hospital based clinico-epidemiological study. BMJ Open 2019, 9: e027850. PMID: 31511281, PMCID: PMC6738675, DOI: 10.1136/bmjopen-2018-027850.Peer-Reviewed Original ResearchConceptsEthics Review CommitteeMultilocus sequence typingOutpatient departmentClinico-epidemiological studyMulticentre prospective studyDay of admissionMicroscopic agglutination testPresence of diseaseHospital stayFebrile patientsMedical wardsProspective studySri Lankan isolatesRisk factorsVenous bloodDisease progressionEthical clearanceHigh incidenceAetiological aspectsPatientsAgglutination testMolecular epidemiologyPatient contextBedside inoculationLeptospirosis
2015
The 2013 measles outbreak in Sri Lanka: experience from a rural district and implications for measles elimination goals
Dahanayaka NJ, Pahalagamage S, Ganegama RM, Weerawansa P, Agampodi SB. The 2013 measles outbreak in Sri Lanka: experience from a rural district and implications for measles elimination goals. Infectious Diseases Of Poverty 2015, 4: 51. PMID: 26627462, PMCID: PMC4667465, DOI: 10.1186/s40249-015-0084-7.Peer-Reviewed Original ResearchConceptsMeasles elimination goalElimination goalsMeasles immunization schedulePosterior cervical lymphadenopathyCommon clinical featuresIntensive care unitUniversity Medical UnitMonths of ageBasic demographic detailsCervical lymphadenopathyKoplik's spotsMaculopapular rashImmunization statusPrior immunizationVaccine scheduleCare unitClinical featuresImmunization scheduleMeasles vaccineSevere pneumoniaMeasles immunizationProspective studyRespiratory difficultyRubella vaccineEpidemiological profile
2012
Predictors of the development of myocarditis or acute renal failure in patients with leptospirosis: An observational study
Dassanayake D, Wimalaratna H, Nandadewa D, Nugaliyadda A, Ratnatunga CN, Agampodi SB. Predictors of the development of myocarditis or acute renal failure in patients with leptospirosis: An observational study. BMC Infectious Diseases 2012, 12: 4. PMID: 22243770, PMCID: PMC3292442, DOI: 10.1186/1471-2334-12-4.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultAgglutination TestsFemaleHospitals, TeachingHumansLeptospirosisMaleMiddle AgedMyocarditisProspective StudiesSri LankaConceptsAcute renal failureRenal failureClinical featuresMicroscopic agglutination testOdds ratioTeaching hospitalExact testComplication of leptospirosisDevelopment of myocarditisLaboratory measuresCommon clinical featuresVaried clinical presentationsProspective descriptive studyPredictors of severityFisher's exact testMann-Whitney U testLogistic regression modelsPain 6ResultsSixty-twoLaboratory parametersClinical presentationLaboratory variablesLaboratory predictorsLeptospirosis patientsCase definition