2023
The Effect of Salacia Reticulata Extract Biscuits on Blood Sugar Control of Type 2 Diabetes Mellitus Patients: A Two-Period, Two-Sequence, Crossover, Randomized, Triple-Blind, Placebo-Controlled, Clinical Trial
Siribaddana S, Medagama A, Wickramasinghe N, Siribaddana N, Agampodi S, Fernando D. The Effect of Salacia Reticulata Extract Biscuits on Blood Sugar Control of Type 2 Diabetes Mellitus Patients: A Two-Period, Two-Sequence, Crossover, Randomized, Triple-Blind, Placebo-Controlled, Clinical Trial. Cureus 2023, 15: e45921. PMID: 37885536, PMCID: PMC10599346, DOI: 10.7759/cureus.45921.Peer-Reviewed Original ResearchType 2 diabetesKothala-himbutuPlacebo biscuitsBiscuit groupTwo-sequenceComputer-generated random numbersTeaching Hospital AnuradhapuraMean HbA1c levelBlood sugar controlPrimary outcome measureTwo-periodHbA1c levelsMean HbA1cGlycemic stabilityGlycemic controlMellitus patientsCrossover studyWashout periodSugar controlHeart diseaseTreatment allocationClinical trialsOutcome measuresPlaceboPatients
2022
Demographic, exposure, clinical, biochemical and diagnostic data of febrile patients recruited for the largest field study on leptospirosis in Sri Lanka
Agampodi S, Warnasekara J, Siribaddana S, Kularatna S, Gamage C, Jayasundara D, Senevirathna I, Srimantha S, Kappagoda C, Weerawansa P, Pilapitiya S, Lokunarangoda N, Sarathchandra C, Senanayake H, Matthias M, Vinetz J. Demographic, exposure, clinical, biochemical and diagnostic data of febrile patients recruited for the largest field study on leptospirosis in Sri Lanka. Data In Brief 2022, 43: 108378. PMID: 35770027, PMCID: PMC9234077, DOI: 10.1016/j.dib.2022.108378.Peer-Reviewed Original ResearchInvolvement of alcohol in injury cases in rural Sri Lanka: prevalence and associated factors among in-patients in three primary care hospitals
Schölin L, Weerasinghe M, Agampodi S, Chathurange U, Rajapaksha S, Holloway A, Norrie J, Mohamed F, Eddleston M, Pearson M. Involvement of alcohol in injury cases in rural Sri Lanka: prevalence and associated factors among in-patients in three primary care hospitals. BMC Public Health 2022, 22: 514. PMID: 35296275, PMCID: PMC8928674, DOI: 10.1186/s12889-022-12958-8.Peer-Reviewed Original ResearchConceptsAlcohol-related injuriesAlcohol Use Disorders Identification TestBlood alcohol concentrationRural Sri LankaAlcohol useInjury characteristicsPrimary care hospitalHospital-based sampleTransport-related injuriesCurrent alcohol usersDisorders Identification TestCurrent alcohol useBinary logistic regressionInvolvement of alcoholHigher AUDIT scoresAdult patientsCare hospitalGlobal morbidityResultsA totalIntentional injuriesAcute intoxicationProblematic alcohol usePatientsPossible alcohol dependenceInjury casesResponse of Human Toll–Like Receptor 2 During the Infection of Leptospirosis
Kappagoda C, Senavirathna I, Warnasekara J, Srimantha S, De Silva N, Agampodi S. Response of Human Toll–Like Receptor 2 During the Infection of Leptospirosis. International Journal Of Infectious Diseases 2022, 116: s71. DOI: 10.1016/j.ijid.2021.12.167.Peer-Reviewed Original ResearchToll-like receptor2Human TLR2 geneTLR2 geneMouse modelToll-like receptor 2Human Toll-like receptor 2Results 64 patientsInnate immune responsePathogenic Leptospira sppGene expression analysisImmune responseStudy populationReceptor 2Receptor responsesTLR2 regulationPatientsLeptospirosisLeptospira sppNew therapeuticsWhole bloodGene expression studiesGene amplificationReverse transcriptaseInfectionTotal RNA
2021
Improving the leptospirosis disease burden assessment by including ambulatory patients from outpatient departments: a cross-sectional study
Warnasekara J, Aberathna P, Nanayakkara G, Vinetz J, Agampodi S. Improving the leptospirosis disease burden assessment by including ambulatory patients from outpatient departments: a cross-sectional study. F1000Research 2021, 9: 1129. PMID: 34123371, PMCID: PMC8145224, DOI: 10.12688/f1000research.26202.2.Peer-Reviewed Original ResearchConceptsOutpatient departmentOPD patientsAmbulatory patientsDisease burdenPrimary care centersProvincial General HospitalCases of leptospirosisCross-sectional studyDisease burden assessmentMicroscopic agglutination testPublic health implicationsQuantitative polymerase chain reactionOPD settingRegional Public HospitalOPD visitsLeptospirosis patientsFever patientsPatient numbersHospital inpatientsPolymerase chain reactionCare centerGeneral HospitalBurden assessmentPatientsSame period
2020
Complete Genome Sequence of Leptospira interrogans Strains FMAS_KW1, FMAS_KW2 and FMAS_AW1 Isolated from Leptospirosis Patients from Karawanalla and Awissawella, Sri Lanka
Senevirathna I, Jayasundara D, Lefler JP, Chaiboonm KL, Warnasekara J, Agampodi S, Matthias MA, Vinetz JM. Complete Genome Sequence of Leptospira interrogans Strains FMAS_KW1, FMAS_KW2 and FMAS_AW1 Isolated from Leptospirosis Patients from Karawanalla and Awissawella, Sri Lanka. Journal Of Genomics 2020, 8: 49-52. PMID: 32494307, PMCID: PMC7256012, DOI: 10.7150/jgen.43953.Peer-Reviewed Original Research
2019
Exploration of the association between contact history, socio-cultural factors and acute deliberate self-poisoning in North Central province of Sri Lanka: a case-control study
Pushpakumara P, Chandrakumara W, Gunasekara A, Agampodi S. Exploration of the association between contact history, socio-cultural factors and acute deliberate self-poisoning in North Central province of Sri Lanka: a case-control study. Anuradhapura Medical Journal 2019, 13: 12. DOI: 10.4038/amj.v13i1.7660.Peer-Reviewed Original ResearchTeaching Hospital AnuradhapuraCase-control studyDSP patientsMedical wardsContact historyYoung adultsSex-matched patientsInterviewer-administered questionnaireSelf-harm incidentsImmediate family membersHistory of DSHRisk groupsResults MajorityNorth Central ProvinceRural Sri LankaPatientsSuicidal behaviorVulnerable adolescentsPossible interventionsWardsFamily membersSuicideAdultsStressful situationsAdolescentsStudy protocol: characterising the clinical, epidemiological and aetiological aspects of leptospirosis in Sri Lanka: a hospital based clinico-epidemiological study
Agampodi S, Warnasekara J, Jayasundara D, Senawirathna I, Gamage C, Kularatne S, Siribaddana S, Maththias M, Vinetz J. Study protocol: characterising the clinical, epidemiological and aetiological aspects of leptospirosis in Sri Lanka: a hospital based clinico-epidemiological study. BMJ Open 2019, 9: e027850. PMID: 31511281, PMCID: PMC6738675, DOI: 10.1136/bmjopen-2018-027850.Peer-Reviewed Original ResearchConceptsEthics Review CommitteeMultilocus sequence typingOutpatient departmentClinico-epidemiological studyMulticentre prospective studyDay of admissionMicroscopic agglutination testPresence of diseaseHospital stayFebrile patientsMedical wardsProspective studySri Lankan isolatesRisk factorsVenous bloodDisease progressionEthical clearanceHigh incidenceAetiological aspectsPatientsAgglutination testMolecular epidemiologyPatient contextBedside inoculationLeptospirosis
2018
A low GLP-1 response among patients treated for acute organophosphate and carbamate poisoning: a comparative cross-sectional study from an agrarian region of Sri Lanka
Rathish D, Senavirathna I, Jayasumana C, Agampodi S, Siribaddana S. A low GLP-1 response among patients treated for acute organophosphate and carbamate poisoning: a comparative cross-sectional study from an agrarian region of Sri Lanka. Environmental Science And Pollution Research 2018, 26: 2864-2872. PMID: 30499084, DOI: 10.1007/s11356-018-3818-9.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholinesteraseAcute DiseaseAdultAtropineCarbamatesChronic DiseaseCross-Sectional StudiesDiabetes Mellitus, Type 2Dose-Response Relationship, DrugErythrocytesFemaleGlucagon-Like Peptide 1HumansIncidenceIncretinsInsecticidesMaleMiddle AgedOccupational ExposureOrganophosphate PoisoningSri LankaConceptsGLP-1 responseComparative cross-sectional studyRBC-AChE activityCross-sectional studyAcute organophosphateControl groupAcute groupLower GLP-1 responseRed blood cell acetylcholinesterase activityGLP-1 pathwayAcetylcholinesterase inhibitor insecticidesAtropine therapyChronic groupCarbamate poisoningGLP-1High incidenceType 2PatientsAcetylcholinesterase activityInhibitor insecticidesPoisoningGroupResponseMin valuesDiabetes
2016
Clinical Features and Transmission Pattern of Hepatitis A: An Experience from a Hepatitis A Outbreak Caused by Two Cocirculating Genotypes in Sri Lanka.
Dahanayaka NJ, Kiyohara T, Agampodi SB, Samaraweera PK, Kulasooriya GK, Ranasinghe JC, Semage SN, Yoshizaki S, Wakita T, Ishii K. Clinical Features and Transmission Pattern of Hepatitis A: An Experience from a Hepatitis A Outbreak Caused by Two Cocirculating Genotypes in Sri Lanka. American Journal Of Tropical Medicine And Hygiene 2016, 95: 908-914. PMID: 27382079, PMCID: PMC5062799, DOI: 10.4269/ajtmh.16-0221.Peer-Reviewed Original ResearchConceptsHepatitis A virusMost patientsHepatitis AHAV immunoglobulin MIntermediate endemic areaAcute viral hepatitisUpper abdominal discomfortHepatitis A outbreaksHigh-risk groupStrains of HAVMilitary personnelAcute hepatitisHAV vaccinationPale stoolsAbdominal discomfortViral hepatitisClinical featuresHepatitis outbreakSubgenotype IAClinical informationInfected personsPatientsA virusHepatitisSerial outbreaksOverdose of oral contraceptive pills as a means of intentional self-poisoning amongst young women in Sri Lanka: considerations for family planning
Weerasinghe M, Konradsen F, Eddleston M, Pearson M, Agampodi T, Storm F, Agampodi S. Overdose of oral contraceptive pills as a means of intentional self-poisoning amongst young women in Sri Lanka: considerations for family planning. BMJ Sexual & Reproductive Health 2016, 43: 147. PMID: 27006385, DOI: 10.1136/jfprhc-2015-101171.Peer-Reviewed Original ResearchOral contraceptive pillsContraceptive pillsUse of OCPYoung womenReproductive health service providersHospital-based studyDay of admissionPopular family planning methodFamily planning methodsPublic health significanceHealth service providersPatient characteristicsMedian ageCase seriesFemale patientsOCP usersPatientsNorth Central ProvinceRural Sri LankaSecondary analysisHealth significanceFamily planningFuture guidelinesOverdoseHospital
2015
Outbreak Investigation of Leptospirosis in Padaviya, Sri Lanka
Ramsey A, Rubin-Smith J, Norwich A, Katumuluwa S, Hettiarachchi A, Wimalage S, Danushka W, Madushanka T, Nadeeshani A, Thilakarathna C, Sewwandi L, Malhari T, Sirisena P, Agampodi S. Outbreak Investigation of Leptospirosis in Padaviya, Sri Lanka. Anuradhapura Medical Journal 2015, 9: 23-26. DOI: 10.4038/amj.v9i2.7532.Peer-Reviewed Original ResearchNumber of casesCases of leptospirosisDiagnosis of leptospirosisRegional Health AuthorityRenal compromiseCardiovascular symptomsClinical presentationRetrospective reviewResultsA totalSame hospitalHigh prevalenceBase hospitalHospital staffPatientsHealth authoritiesOutbreak investigationLeptospirosisTropical diseasesPrevious outbreaksHypotensionBradycardiaRecent outbreakAdmissionHospitalParticular outbreakDrinking well water and occupational exposure to Herbicides is associated with chronic kidney disease, in Padavi-Sripura, Sri Lanka
Jayasumana C, Paranagama P, Agampodi S, Wijewardane C, Gunatilake S, Siribaddana S. Drinking well water and occupational exposure to Herbicides is associated with chronic kidney disease, in Padavi-Sripura, Sri Lanka. Environmental Health 2015, 14: 6. PMID: 25596925, PMCID: PMC4417209, DOI: 10.1186/1476-069x-14-6.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseKidney diseaseHigh riskImportant public health issueResultsMajority of patientsCase-control studyPublic health issueMultivariable analysisUnknown etiologyEntry criteriaRisk factorsEffect modificationHigh prevalenceOccupational exposureEndemic areasDrinking waterCKDu patientsControl studyPersonnel protective equipmentProtective equipmentHealth issuesPatientsHospitalMale farmersCKDu
2014
Validity of a commercially available IgM ELISA test for diagnosing acute leptospirosis in high endemic districts of Sri Lanka
Agampodi S, Thevanesam V, Senaratne T. Validity of a commercially available IgM ELISA test for diagnosing acute leptospirosis in high endemic districts of Sri Lanka. Sri Lankan Journal Of Infectious Diseases 2014, 4: 83. DOI: 10.4038/sljid.v4i2.6952.Peer-Reviewed Original ResearchIgM ELISADiagnosis of leptospirosisConvalescent samplesImmunoglobulin M enzymeDays of illnessComparison groupCases of leptospirosisIgM ELISA kitResultsThe study sampleDepartment of MicrobiologyCare diagnostic testsFebrile patientsAcute leptospirosisFever patientsAcute samplesFaculty of MedicineHuman leptospirosisDay 14Disease confirmationELISA kitLeptospirosisPatientsDiagnostic testsImmunosorbent assayStudy sampleCharacteristics of Rural Leptospirosis Patients Admitted to Referral Hospitals During the 2008 Leptospirosis Outbreak in Sri Lanka: Implications for Developing Public Health Control Measures
Agampodi SB, Nugegoda DB, Thevanesam V, Vinetz JM. Characteristics of Rural Leptospirosis Patients Admitted to Referral Hospitals During the 2008 Leptospirosis Outbreak in Sri Lanka: Implications for Developing Public Health Control Measures. American Journal Of Tropical Medicine And Hygiene 2014, 92: 139-144. PMID: 25331809, PMCID: PMC4347370, DOI: 10.4269/ajtmh.14-0465.Peer-Reviewed Original ResearchConceptsRisk factorsHospital-based case-control studyPublic health control measuresCase-control studyExposure risk factorsHealth control measuresFebrile patientsReferral hospitalCase patientsLeptospirosis patientsMean ageControl studyTropical settingsPatientsVicinity of homeLeptospirosis outbreaksDog ownershipIndividual exposureLeptospirosisMain predictorsDisease transmissionControl measuresMajor roleHospitalSetting
2013
Emergence of cutaneous leishmaniasis in Polonnaruwa, Sri Lanka 2008–2011
Sandanayaka R, Kahawita I, Gamage A, Siribaddana S, Agampodi S. Emergence of cutaneous leishmaniasis in Polonnaruwa, Sri Lanka 2008–2011. Tropical Medicine And International Health 2013, 19: 140-145. PMID: 24438012, DOI: 10.1111/tmi.12232.Peer-Reviewed Original ResearchConceptsCutaneous leishmaniasisAnnual incidenceMajority of patientsMean annual incidencePolonnaruwa districtDermatology unitClinical detailsGeneral HospitalStudy populationEpidemiology UnitUpper limbLeishmaniasis surveillanceCase incidenceLeishmaniasisPatientsStudy periodIncidenceCommon typeCase distributionLesionsMore malesHospitalPopulationPolonnaruwaSri LankaOutbreak of leptospirosis after white-water rafting: sign of a shift from rural to recreational leptospirosis in Sri Lanka?
AGAMPODI SB, KARUNARATHNA D, JAYATHILALA N, RATHNAYAKA H, AGAMPODI TC, KARUNANAYAKA L. Outbreak of leptospirosis after white-water rafting: sign of a shift from rural to recreational leptospirosis in Sri Lanka? Epidemiology And Infection 2013, 142: 843-846. PMID: 23800619, PMCID: PMC9151153, DOI: 10.1017/s0950268813001465.Peer-Reviewed Original ResearchConceptsMAT titresPositive IgM ELISAClassical clinical featuresAnti-leptospiral antibodiesHistory of leptospirosisOutbreak of leptospirosisEpidemiology of leptospirosisAfebrile patientsClinical featuresAcute leptospirosisFever patientsIgM ELISAAffluent urban populationsOccupational hazardsOutbreak investigationLeptospirosisLeptospirosis outbreaksOffice workersPatientsTitresWeeksExposureParticipantsOutbreakRecreational activities
2012
Disease Burden Assessment Beyond In-patient Data: A Morbidity Profile Assessment of Outpatients.
Dharmaratne S, Agampodi S, Dassanayaka S, Kumarihami P, Ratnayake A, Wickramathilake S. Disease Burden Assessment Beyond In-patient Data: A Morbidity Profile Assessment of Outpatients. International Journal Of Preventive Medicine 2012, 3: 730-2. PMID: 23112901, PMCID: PMC3483002.Peer-Reviewed Original ResearchOutpatient departmentMorbidity profileMean ageGlobal disease burden estimatesCommon presenting complainsDisease burden estimatesStudy samplePresenting complainsAbdominal painOPD patientsHospital PeradeniyaBody achesPatient populationHospital visitsMorbidity patternBurden estimatesSystematic random sampling procedurePatientsMinor ailmentsGovernment hospitalsMajor occupational groupsPatient dataPainProfile assessmentOccupational groups
2010
Determinants of leptospirosis in Sri Lanka: Study Protocol
Agampodi SB, Nugegoda DB, Thevanesam V. Determinants of leptospirosis in Sri Lanka: Study Protocol. BMC Infectious Diseases 2010, 10: 332. PMID: 21087520, PMCID: PMC2994874, DOI: 10.1186/1471-2334-10-332.Peer-Reviewed Original ResearchConceptsFever patientsStudy protocolMajor public health threatMajor modifiable determinantsCase-control studyPublic health threatStandard laboratory criteriaCase-control designLogistic regression modelsNational control programLaboratory criteriaModifiable determinantsEndemic districtsCase confirmationControl studyProbable casesSocio-demographic variablesExposure variablesLeptospirosisLocal transmissionHealth threatBaseline dataCase selectionPatientsStudy results
2009
Evaluation of surveillance case definition in the diagnosis of leptospirosis, using the Microscopic Agglutination Test: a validation study
Dassanayake D, Wimalaratna H, Agampodi SB, Liyanapathirana VC, Piyarathna T, Goonapienuwala BL. Evaluation of surveillance case definition in the diagnosis of leptospirosis, using the Microscopic Agglutination Test: a validation study. BMC Infectious Diseases 2009, 9: 48. PMID: 19386085, PMCID: PMC2679753, DOI: 10.1186/1471-2334-9-48.Peer-Reviewed Original ResearchConceptsSurveillance case definitionMicroscopic agglutination testCase definitionNegative predictive valuePredictive valueClinical featuresMAT titresAgglutination testDays of feverAcute febrile illnessMethodsThe study populationTeaching Hospital KandyPositive predictive valueDiagnosis of leptospirosisPositive MAT resultsFebrile illnessMedical wardsResultsA totalHospital KandyStudy populationBlood samplesConclusionThis studyPatientsDiagnostic accuracyLeptospirosis