2022
Culture-Independent Detection and Identification of Leptospira Serovars
Matthias M, Lubar A, Acharige S, Chaiboonma K, Pilau N, Marroquin A, Jayasundara D, Agampodi S, Vinetz J. Culture-Independent Detection and Identification of Leptospira Serovars. Microbiology Spectrum 2022, 10: e02475-22. PMID: 36445143, PMCID: PMC9769591, DOI: 10.1128/spectrum.02475-22.Peer-Reviewed Original ResearchConceptsPublic health importanceProspective studyFatal diseaseHealth importanceOutbreak investigationSequence typingDog urine samplesCulture-independent assaysEnvironmental surveillance studyMultilocus sequence typingPulsed-field gel electrophoresisSurveillance studyGroup IIHuman leptospirosisPrognostic testSpecific real-time qPCRClinical settingGroup ILeptospira serovarsReal-time qPCRDiagnostic testsSerum samplesUrine samplesDiagnostic specificityLeptospirosis
2019
A Case–Control Study of Environmental and Occupational Risks of Leptospirosis in Sri Lanka
Schønning MH, Phelps MD, Warnasekara J, Agampodi SB, Furu P. A Case–Control Study of Environmental and Occupational Risks of Leptospirosis in Sri Lanka. EcoHealth 2019, 16: 534-543. PMID: 31664587, DOI: 10.1007/s10393-019-01448-w.Peer-Reviewed Original ResearchConceptsPaddy workersOdds ratioSignificant higher riskCase-control studyHigher odds ratioPublic health interventionsTransmission of leptospirosisRisk factorsOccupational exposureProtective effectHigh riskHigh incidenceRat exposureHuman leptospirosisViral infectionHealth interventionsZoonotic infectionOccupational riskLeptospirosisLeptospirosis transmissionStudy sampleOccupational groupsInfectionStructured interviewsHousehold animals
2016
Etiological agents causing leptospirosis in Sri Lanka: A review
Naotunna C, Agampodi SB, Agampodi TC. Etiological agents causing leptospirosis in Sri Lanka: A review. Asian Pacific Journal Of Tropical Medicine 2016, 9: 390-394. PMID: 27086159, DOI: 10.1016/j.apjtm.2016.03.009.Peer-Reviewed Original ResearchEtiological agentDirect patient samplesPatients/animalsArticles/reportsMulti-locus sequence typingIsolation of LeptospiraSri Lankan isolatesHuman leptospirosisLocus sequence typingPatient samplesLeptospira santarosaiLeptospira kirschneriLeptospira interrogansLeptospira borgpeterseniiEpidemiology papersSequence typingLeptospirosisLeptospiraNew typing methodTyping methodsRecent studiesIsolatesSri LankaReviewAgents
2014
Validity of a commercially available IgM ELISA test for diagnosing acute leptospirosis in high endemic districts of Sri Lanka
Agampodi S, Thevanesam V, Senaratne T. Validity of a commercially available IgM ELISA test for diagnosing acute leptospirosis in high endemic districts of Sri Lanka. Sri Lankan Journal Of Infectious Diseases 2014, 4: 83. DOI: 10.4038/sljid.v4i2.6952.Peer-Reviewed Original ResearchIgM ELISADiagnosis of leptospirosisConvalescent samplesImmunoglobulin M enzymeDays of illnessComparison groupCases of leptospirosisIgM ELISA kitResultsThe study sampleDepartment of MicrobiologyCare diagnostic testsFebrile patientsAcute leptospirosisFever patientsAcute samplesFaculty of MedicineHuman leptospirosisDay 14Disease confirmationELISA kitLeptospirosisPatientsDiagnostic testsImmunosorbent assayStudy sample
2012
Utility and Limitations of Direct Multi-Locus Sequence Typing on qPCR-Positive Blood to Determine Infecting Leptospira Strain
Agampodi SB, Moreno AC, Vinetz JM, Matthias MA. Utility and Limitations of Direct Multi-Locus Sequence Typing on qPCR-Positive Blood to Determine Infecting Leptospira Strain. American Journal Of Tropical Medicine And Hygiene 2012, 88: 184-185. PMID: 23208890, PMCID: PMC3541733, DOI: 10.4269/ajtmh.2012.12-0526.Peer-Reviewed Original ResearchConceptsPolymerase chain reaction-positive samplesBacterial loadLeptospira strainsMLST profilesAcute illnessBlood samplesHuman leptospirosisComplete MLST profilesCulture isolationMulti-locus sequenceHuman bloodSequence typesBloodCentral Sri LankaInterpretable dataMolecular characterizationIllnessLeptospirosisST44