2022
Diagnostic method-based underestimation of leptospirosis in clinical and research settings; an experience from a large prospective study in a high endemic setting
Warnasekara J, Srimantha S, Kappagoda C, Jayasundara D, Senevirathna I, Matthias M, Agampodi S, Vinetz J. Diagnostic method-based underestimation of leptospirosis in clinical and research settings; an experience from a large prospective study in a high endemic setting. PLOS Neglected Tropical Diseases 2022, 16: e0010331. PMID: 35377883, PMCID: PMC9009773, DOI: 10.1371/journal.pntd.0010331.Peer-Reviewed Original ResearchConceptsMicroscopic agglutination testProspective hospital-based studyLeptospirosis casesQuantitative PCRHigh endemic settingHospital-based studyClinical case definitionLarge prospective studiesDisease burden estimatesPublic health burdenStandard diagnostic testMonths of observationUndifferentiated feverAcute leptospirosisProspective studyCase definitionEndemic settingsHealth burdenTimely diagnosisBurden estimatesDiagnostic valueSignificant human mortalityAgglutination testStudy settingDiagnostic tests
2012
Disease Burden Assessment Beyond In-patient Data: A Morbidity Profile Assessment of Outpatients.
Dharmaratne S, Agampodi S, Dassanayaka S, Kumarihami P, Ratnayake A, Wickramathilake S. Disease Burden Assessment Beyond In-patient Data: A Morbidity Profile Assessment of Outpatients. International Journal Of Preventive Medicine 2012, 3: 730-2. PMID: 23112901, PMCID: PMC3483002.Peer-Reviewed Original ResearchOutpatient departmentMorbidity profileMean ageGlobal disease burden estimatesCommon presenting complainsDisease burden estimatesStudy samplePresenting complainsAbdominal painOPD patientsHospital PeradeniyaBody achesPatient populationHospital visitsMorbidity patternBurden estimatesSystematic random sampling procedurePatientsMinor ailmentsGovernment hospitalsMajor occupational groupsPatient dataPainProfile assessmentOccupational groups
2011
Leptospirosis Outbreak in Sri Lanka in 2008: Lessons for Assessing the Global Burden of Disease
Agampodi SB, Peacock SJ, Thevanesam V, Nugegoda DB, Smythe L, Thaipadungpanit J, Craig SB, Burns MA, Dohnt M, Boonsilp S, Senaratne T, Kumara A, Palihawadana P, Perera S, Vinetz JM. Leptospirosis Outbreak in Sri Lanka in 2008: Lessons for Assessing the Global Burden of Disease. American Journal Of Tropical Medicine And Hygiene 2011, 85: 471-478. PMID: 21896807, PMCID: PMC3163869, DOI: 10.4269/ajtmh.2011.11-0276.Peer-Reviewed Original ResearchConceptsAcute renal failureLeptospirosis outbreaksCase fatality rateLimited diagnostic capacityDisease burden estimatesLaboratory diagnostic capabilitiesEndemic infectious diseasesCause of epidemicSerovars PyrogenesClinical characteristicsRenal failureHeart failurePatient populationMain complicationsCase definitionBurden estimatesGlobal burdenCase confirmationHigh titersInfectious diseasesDiagnostic capacityHigh endemicityReference groupLeptospira interrogansDisease