2024
Neuroimaging Biomarkers in Parkinson’s Disease
Holmes S, Tinaz S. Neuroimaging Biomarkers in Parkinson’s Disease. Advances In Neurobiology 2024, 40: 617-663. PMID: 39562459, DOI: 10.1007/978-3-031-69491-2_21.Peer-Reviewed Original ResearchConceptsPublic health burdenNeuroimaging biomarkersTreatment developmentRisk of developing PDParkinson's diseaseHealth burdenDiagnosis of PDMultimodal neuroimaging techniquesIdiopathic Parkinson's diseaseNon-motorDifferential diagnosis of PDNeuroimaging techniquesProdromal phaseDifferential diagnosisSymptomatic treatmentDisease progressionClinical applicationBiomarkers
2023
Stroke in Parkinson’s disease: a review of epidemiological studies and potential pathophysiological mechanisms
Elfil M, Bayoumi A, Sayed A, Aladawi M, Aboutaleb P, Grieb L, Tolba H, Tinaz S. Stroke in Parkinson’s disease: a review of epidemiological studies and potential pathophysiological mechanisms. Acta Neurologica Belgica 2023, 123: 773-783. PMID: 36710306, DOI: 10.1007/s13760-023-02202-4.Peer-Reviewed Original ResearchConceptsParkinson's diseaseEpidemiological studiesNeurological disordersRate of PDCumulative cardiovascular riskRisk of strokePost-stroke complicationsPotential pathophysiological mechanismsRecent epidemiological studiesQuality of lifeCardiovascular riskIschemic insultPathophysiological mechanismsPD patientsNeurological causesEtiological factorsSleep disordersMotor impairmentStrokeDiseasePathological processesDisordersRiskReviewMorbidity
2022
Mental imagery content is associated with disease severity and specific brain functional connectivity changes in patients with Parkinson’s disease
Cherry J, Kamel S, Elfil M, Aravala S, Bayoumi A, Patel A, Sinha R, Tinaz S. Mental imagery content is associated with disease severity and specific brain functional connectivity changes in patients with Parkinson’s disease. Brain Imaging And Behavior 2022, 17: 161-171. PMID: 36434490, PMCID: PMC10050121, DOI: 10.1007/s11682-022-00749-z.Peer-Reviewed Original ResearchConceptsImagery trainingFunctional connectivity changesMild Parkinson's diseaseVisual imagery trainingMental imagery trainingComplex cognitive processesConnectivity changesMotor imagery trainingBrain functional connectivity changesFunctional connectivity characteristicsExecutive processesMental imageryCognitive processesPerceptual experienceNeural correlatesBrain mechanismsImagery practiceImagery contentSensorimotor processesNeuropsychiatric patient populationsMotor functionMotor actsMotor enhancementBrain areasParkinson's disease
2019
Parkinson's Disease Dementia and Lewy Body Disease
Sezgin M, Bilgic B, Tinaz S, Emre M. Parkinson's Disease Dementia and Lewy Body Disease. Seminars In Neurology 2019, 39: 274-282. PMID: 30925619, DOI: 10.1055/s-0039-1678579.Peer-Reviewed Original ResearchConceptsParkinson's disease dementiaDisease dementiaCognitive symptomsBehavioral symptomsLewy body diseaseCerebrospinal fluid biomarkersTime of onsetAutonomic dysfunctionExtrapyramidal symptomsBody diseaseClinical featuresNeuropathological findingsNeuropsychiatric symptomsRandomized trialsClinical pictureLewy bodiesFluid biomarkersClinical differentiationSleep disordersCholinesterase inhibitorsCognitive impairmentSymptomsDementiaNeurodegenerative disordersDLB
2018
Semiquantitative Analysis of Dopamine Transporter Scans in Patients With Parkinson Disease
Tinaz S, Chow C, Kuo PH, Krupinski EA, Blumenfeld H, Louis ED, Zubal G. Semiquantitative Analysis of Dopamine Transporter Scans in Patients With Parkinson Disease. Clinical Nuclear Medicine 2018, 43: e1-e7. PMID: 29112012, PMCID: PMC7257254, DOI: 10.1097/rlu.0000000000001885.Peer-Reviewed Original ResearchConceptsStriatal binding ratiosDAT scanParkinson's diseaseParkinson's Progression Markers Initiative (PPMI) databaseDopamine transporter imagingDopamine transporter scanAdjunct diagnostic toolBinding ratioOutpatient cohortPPMI cohortTransporter imagingParkinsonian disordersMotor severityHealthy controlsClinical measuresStriatal regionsVisual readsTest cohortTest patientsSignificant negative correlationPatientsPPMI databaseDiagnostic aidCohortTraining group
2016
Changes in functional organization and white matter integrity in the connectome in Parkinson's disease
Tinaz S, Lauro PM, Ghosh P, Lungu C, Horovitz SG. Changes in functional organization and white matter integrity in the connectome in Parkinson's disease. NeuroImage Clinical 2016, 13: 395-404. PMID: 28116232, PMCID: PMC5226806, DOI: 10.1016/j.nicl.2016.12.019.Peer-Reviewed Original ResearchConceptsParkinson's diseaseWhite matter integrityPD patientsPD groupWhite matter connectivity changesResting-state functional MRINon-demented PD patientsEarly disease stagesCortico-striatal circuitsWhite matter connectivityDopaminergic medicationDorsal attention networkDisease stageFunctional organizationSensorimotor networkWhole-brain connectomeFunctional modular organizationWhite matterFunctional MRIConnectivity changesDiseasePatientsDiffusion tensorDefault modeBrain connectome
2015
Role of the right dorsal anterior insula in the urge to tic in tourette syndrome
Tinaz S, Malone P, Hallett M, Horovitz SG. Role of the right dorsal anterior insula in the urge to tic in tourette syndrome. Movement Disorders 2015, 30: 1190-1197. PMID: 25855089, PMCID: PMC5088605, DOI: 10.1002/mds.26230.Peer-Reviewed Original ResearchConceptsRight dorsal anterior insulaDorsal anterior insulaTourette syndromeAnterior insulaFunctional connectivityBilateral supplementary motor areaResting-state functional magnetic resonance imagingAdult Tourette patientsSupplementary motor areaDorsal-anterior partFunctional magnetic resonance imagingMagnetic resonance imagingCortico-striatoTourette patientsUrge suppressionHealthy subjectsMotor areaThalamic regionsTic severityPremonitory urgesPatientsSyndromeUrge severityResonance imagingTic generationDeficits in task-set maintenance and execution networks in Parkinson’s disease
Tinaz S, Lauro P, Hallett M, Horovitz SG. Deficits in task-set maintenance and execution networks in Parkinson’s disease. Brain Structure And Function 2015, 221: 1413-1425. PMID: 25567420, PMCID: PMC5565229, DOI: 10.1007/s00429-014-0981-8.Peer-Reviewed Original Research
2014
Role of the sensorimotor cortex in tourette syndrome using multimodal imaging
Tinaz S, Belluscio BA, Malone P, van der Veen J, Hallett M, Horovitz SG. Role of the sensorimotor cortex in tourette syndrome using multimodal imaging. Human Brain Mapping 2014, 35: 5834-5846. PMID: 25044024, PMCID: PMC4776755, DOI: 10.1002/hbm.22588.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidSensorimotor cortexTourette syndromeFunctional magnetic resonance imagingBeta band powerH-Magnetic Resonance SpectroscopyState functional connectivity patternsMagnetic resonance imagingFunctional connectivity patternsMost patientsProcessing disturbancesSensory processing disturbanceVocal ticsLimbic inputsMotor phenomenaPremonitory sensationsPatientsResonance imagingTic generationNeuropsychiatric disordersAnterior insulaBand powerBeta oscillationsBeta activitySyndrome
2010
Focal cortical and subcortical atrophy in early Parkinson's disease
Tinaz S, Courtney MG, Stern CE. Focal cortical and subcortical atrophy in early Parkinson's disease. Movement Disorders 2010, 26: 436-441. PMID: 21462259, PMCID: PMC4502575, DOI: 10.1002/mds.23453.Peer-Reviewed Original ResearchConceptsParkinson's disease patientsDisease patientsParkinson's diseaseDisease groupEarly-stage Parkinson's disease patientsSubstantia nigra pars compactaAnxiety state scoresFocal cortical thinningEarly Parkinson's diseaseParkinson's disease groupCortical thickness changesManifest Parkinson's diseaseStriatal volume lossSubcortical structural changesOccipito-parietal areasHealthy control participantsLimbic cortexPars compactaSubcortical atrophyCortical thinningVentrolateral prefrontal cortexCortical thicknessSubcortical volumesControl groupAlzheimer's disease
2005
Evidence for the importance of basal ganglia output nuclei in semantic event sequencing: An fMRI study
Tinaz S, Schendan HE, Schon K, Stern CE. Evidence for the importance of basal ganglia output nuclei in semantic event sequencing: An fMRI study. Brain Research 2005, 1067: 239-249. PMID: 16360121, DOI: 10.1016/j.brainres.2005.10.057.Peer-Reviewed Original ResearchConceptsPicture sequencing taskSequencing taskBasal ganglia output nucleiEvent sequencingHigh-level cognitive functionsFrontal lobeDorsolateral prefrontal cortexSequential orderingOutput nucleiNeural representationDiscrimination taskFMRI studyPicture sequencingPrefrontal cortexCognitive functionNeural systemsControl taskSelective updatingMeaningful eventsTaskSignificant activationKey computationRandom orderTemporal relationshipFMRI