2009
Role of hippocampal sodium channel Nav1.6 in kindling epileptogenesis
Blumenfeld H, Lampert A, Klein JP, Mission J, Chen MC, Rivera M, Dib‐Hajj S, Brennan AR, Hains BC, Waxman SG. Role of hippocampal sodium channel Nav1.6 in kindling epileptogenesis. Epilepsia 2009, 50: 44-55. PMID: 18637833, PMCID: PMC3741044, DOI: 10.1111/j.1528-1167.2008.01710.x.Peer-Reviewed Original ResearchConceptsHippocampal CA3 neuronsActivity-dependent facilitationCA3 neuronsCommon nervous system disordersSodium channel protein expressionSodium currentCentral nervous system plasticityChannel messenger RNAExpression of Nav1.6Sham-kindled controlsSodium channel Nav1.6Development of kindlingNervous system plasticityNervous system disordersWild-type miceRate of kindlingChannel protein expressionMessenger RNAPatch-clamp recordingsActivity-dependent plasticityPersistent sodium currentIon channel expressionNormal hippocampal functionAction potential generationAbnormal plasticity
1999
Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain
Dib-Hajj S, Fjell J, Cummins TR, Zheng Z, Fried K, LaMotte R, Black JA, Waxman S. Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain. Pain 1999, 83: 591-600. PMID: 10568868, DOI: 10.1016/s0304-3959(99)00169-4.Peer-Reviewed Original ResearchConceptsTTX-R sodium channelsChronic constriction injury modelDRG neuronsSodium currentSodium channelsNeuropathic painInjury modelAxotomized dorsal root ganglion (DRG) neuronsSmall-diameter DRG neuronsTTX-R sodium currentsDorsal root ganglion neuronsTTX-S currentsSodium channel expressionGanglion neuronsSciatic nerveChannel expressionSodium channel transcriptsNeuronsNa currentPainChannel transcriptsSignificant changesLevels of transcriptsHyperalgesiaPrevious studies
1998
Glial cells have heart: rH1 Na+ channel mRNA and protein in spinal cord astrocytes
Black JA, Dib‐Hajj S, Cohen S, Hinson AW, Waxman SG. Glial cells have heart: rH1 Na+ channel mRNA and protein in spinal cord astrocytes. Glia 1998, 23: 200-208. PMID: 9633805, DOI: 10.1002/(sici)1098-1136(199807)23:3<200::aid-glia3>3.0.co;2-8.Peer-Reviewed Original ResearchConceptsTTX-resistant currentStellate astrocytesSpinal cordCultured spinal cord astrocytesVoltage-sensitive sodium currentsChannel mRNASodium currentDorsal root ganglion neuronsSodium channel immunoreactivityRT-PCRSpinal cord astrocytesTTX-sensitive currentsIntact spinal cordSpinal cord culturesReverse transcription-polymerase chain reactionSodium channel mRNASodium channel expressionTranscription-polymerase chain reactionTTX-resistant channelsPolyclonal antibodiesChannel immunoreactivityP7 ratsGanglion neuronsPolymerase chain reactionChannel antibodiesSNS Na+ channel expression increases in dorsal root ganglion neurons in the carrageenan inflammatory pain model
Tanaka M, Cummins T, Ishikawa K, Dib-Hajj S, Black J, Waxman S. SNS Na+ channel expression increases in dorsal root ganglion neurons in the carrageenan inflammatory pain model. Neuroreport 1998, 9: 967-972. PMID: 9601651, DOI: 10.1097/00001756-199804200-00003.Peer-Reviewed Original ResearchConceptsSmall DRG neuronsDorsal root ganglion neuronsInjection of carrageenanDRG neuronsInflamed limbGanglion neuronsSodium currentTTX-R sodium currentsTetrodotoxin-resistant sodium currentInflammatory pain modelDevelopment of hyperexcitabilitySodium channel expressionPatch-clamp recordingsInflammatory painPain modelChronic painCarrageenan injectionNociceptive cellsContralateral sideNaive ratsChannel expressionProjection fieldsMRNA expressionNeuronsSodium channels
1997
Schwann cells modulate sodium channel expression in spinal sensory neurons in vitro
Hinson AW, Gu XQ, Dib‐Hajj S, Black JA, Waxman SG. Schwann cells modulate sodium channel expression in spinal sensory neurons in vitro. Glia 1997, 21: 339-349. PMID: 9419009, DOI: 10.1002/(sici)1098-1136(199712)21:4<339::aid-glia1>3.0.co;2-z.Peer-Reviewed Original ResearchConceptsDRG neuronsSC-conditioned mediumSodium channel alphaE15 ratsSodium channelsChannel alphaSodium channel immunoreactivitySpinal sensory neuronsBeta2 subunit mRNASodium channel mRNASodium channel expressionFunctional sodium channelsSodium current densityBeta-subunit mRNAChannel immunoreactivityBeta2 mRNASensory neuronsClamp recordingsChannel expressionChannel mRNAIsoform-specific riboprobesNeuronsBeta1RatsHybridization signalsNaG: A sodium channel‐like mRNA shared by Schwann cells and other neural crest derivatives
Felts PA, Black JA, Dib‐Hajj S, Waxman SG. NaG: A sodium channel‐like mRNA shared by Schwann cells and other neural crest derivatives. Glia 1997, 21: 269-276. PMID: 9383036, DOI: 10.1002/(sici)1098-1136(199711)21:3<269::aid-glia2>3.0.co;2-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGanglia, SpinalIn Situ HybridizationNeural CrestPolymerase Chain ReactionRatsRats, Sprague-DawleyRNA, MessengerSchwann CellsSodium ChannelsConceptsNeural crest originSchwann cellsGanglion neuronsNeural crest derivativesRat dorsal root ganglion neuronsAdrenal medulla chromaffin cellsDorsal root ganglion neuronsSuperior cervical ganglion neuronsSodium channelsCrest derivativesNeural crestNeuronal cell typesAfferent neuronsAfferent functionSitu hybridizationSensory neuronsNeural elementsSensory functionChromaffin cellsNAG mRNANeuronsRT-PCRNAGCell typesPresent study