1999
Coding Sequence, Genomic Organization, and Conserved Chromosomal Localization of the Mouse Gene Scn11a Encoding the Sodium Channel NaN
Dib-Hajj S, Tyrrell L, Escayg A, Wood P, Meisler M, Waxman S. Coding Sequence, Genomic Organization, and Conserved Chromosomal Localization of the Mouse Gene Scn11a Encoding the Sodium Channel NaN. Genomics 1999, 59: 309-318. PMID: 10444332, DOI: 10.1006/geno.1999.5890.Peer-Reviewed Original ResearchConceptsSodium channel geneChannel genesConserved linkage groupMouse chromosome 9Sodium channel alphaAlternative exon 5Amino acid levelsGenomic organizationChromosomal localizationLinkage groupsHuman genesHuman SCN5ACoding sequenceCommon lineageChannel alphaChromosome 9TTX-R sodium channelsGenesSmall-diameter sensory neuronsTransduction of painDorsal root gangliaHigh-threshold nociceptorsExon 5SCN11A geneSodium channels
1995
A UV-induced, Mg(2+)-dependent crosslink traps an active form of domain 3 of a self-splicing group II intron.
Podar M, Dib-Hajj S, Perlman P. A UV-induced, Mg(2+)-dependent crosslink traps an active form of domain 3 of a self-splicing group II intron. RNA 1995, 1: 828-40. PMID: 7493328, PMCID: PMC1369323.Peer-Reviewed Original ResearchStudies of Point Mutants Define Three Essential Paired Nucleotides in the Domain 5 Substructure of a Group II Intron
Boulanger S, Belcher S, Schmidt U, Dib-Hajj S, Schmidt T, Perlman P. Studies of Point Mutants Define Three Essential Paired Nucleotides in the Domain 5 Substructure of a Group II Intron. Molecular And Cellular Biology 1995, 15: 4479-4488. PMID: 7623838, PMCID: PMC230687, DOI: 10.1128/mcb.15.8.4479.Peer-Reviewed Original ResearchConceptsGroup II intronsU6 small nuclear RNADominant nuclear suppressorBase pairsSaccharomyces cerevisiae mitochondriaPoint mutationsSecond-site suppressorsSmall nuclear RNAYeast U2Nuclear suppressorCoxI geneCerevisiae mitochondriaRespiratory growthVivo splicingBiolistic transformationNuclear RNAHelix 1C base pairsSplicingIntronsDomain 5MutantsMutationsNucleotidesSuppressor
1992
Group II introns deleted for multiple substructures retain self-splicing activity.
Koch J, Boulanger S, Dib-Hajj S, Hebbar S, Perlman P. Group II introns deleted for multiple substructures retain self-splicing activity. Molecular And Cellular Biology 1992, 12: 1950-1958. PMID: 1569932, PMCID: PMC364365, DOI: 10.1128/mcb.12.5.1950.Peer-Reviewed Original ResearchConceptsGroup II intronsSplice site selectionSelf-splicing activitySplice junctionsDomain 2Domain 5Domain 1Essential catalytic coreYeast mitochondrial DNASecondary structure elementsCoxI geneSelf-splicing reactionMitochondrial DNAPrecursor RNAMutant intronsCatalytic coreIntron domainsTriple deletionIntronsTrans assaySingle deletionSecondary structureDomain 6DeletionStructure elements