2024
Disordered but effective: short linear motifs as gene therapy targets for hyperexcitability disorders
Dib-Hajj S, Waxman S. Disordered but effective: short linear motifs as gene therapy targets for hyperexcitability disorders. Journal Of Clinical Investigation 2024, 134: e182198. PMID: 38949022, PMCID: PMC11213459, DOI: 10.1172/jci182198.Peer-Reviewed Original ResearchConceptsTetrodotoxin-sensitiveHyperexcitability disordersSensory neuronsExcitability of sensory neuronsGene therapy modalitiesPeripheral sensory neuronsVoltage-gated sodiumMinimal side effectsGene therapyInduce analgesiaTherapy modalitiesSide effectsTherapeutic strategiesNav channelsAttenuating excitationIn vivoHyperexcitabilityAnalgesiaNeuronsDisordersPainTherapyGenesBiodistributionRats
1997
Schwann cells modulate sodium channel expression in spinal sensory neurons in vitro
Hinson AW, Gu XQ, Dib‐Hajj S, Black JA, Waxman SG. Schwann cells modulate sodium channel expression in spinal sensory neurons in vitro. Glia 1997, 21: 339-349. PMID: 9419009, DOI: 10.1002/(sici)1098-1136(199712)21:4<339::aid-glia1>3.0.co;2-z.Peer-Reviewed Original ResearchConceptsDRG neuronsSC-conditioned mediumSodium channel alphaE15 ratsSodium channelsChannel alphaSodium channel immunoreactivitySpinal sensory neuronsBeta2 subunit mRNASodium channel mRNASodium channel expressionFunctional sodium channelsSodium current densityBeta-subunit mRNAChannel immunoreactivityBeta2 mRNASensory neuronsClamp recordingsChannel expressionChannel mRNAIsoform-specific riboprobesNeuronsBeta1RatsHybridization signals