2023
Integrative miRNA–mRNA profiling of human epidermis: unique signature of SCN9A painful neuropathy
Andelic M, Salvi E, Marcuzzo S, Marchi M, Lombardi R, Cartelli D, Cazzato D, Mehmeti E, Gelemanovic A, Paolini M, Pardo C, D'Amato I, Hoeijmakers J, Dib-Hajj S, Waxman S, Faber C, Lauria G. Integrative miRNA–mRNA profiling of human epidermis: unique signature of SCN9A painful neuropathy. Brain 2023, 146: 3049-3062. PMID: 36730021, PMCID: PMC10316770, DOI: 10.1093/brain/awad025.Peer-Reviewed Original ResearchConceptsNeuropathic painPain-related mechanismsCohort of patientsSmall nerve fibersUnmet clinical needPainful neuropathyTargeted molecular profilingNeuropathy painPathophysiological mechanismsAvailable therapiesPreclinical modelsNerve fibersLimited efficacyHealthy individualsPersonalized managementPotential drug candidatesTranslational gapPainClinical needGene targetsPatientsImmunofluorescence assaysMolecular profilingMiR-30 familyProtein expression
2022
Maximizing treatment efficacy through patient stratification in neuropathic pain trials
Baron R, Dickenson A, Calvo M, Dib-Hajj S, Bennett D. Maximizing treatment efficacy through patient stratification in neuropathic pain trials. Nature Reviews Neurology 2022, 19: 53-64. PMID: 36400867, DOI: 10.1038/s41582-022-00741-7.Peer-Reviewed Original ResearchConceptsNeuropathic painPain medicineOutcome measuresClinical practiceNeuropathic pain etiologyNeuropathic pain trialsPatient stratification approachesMultiple pathophysiological mechanismsSubgrouping of patientsRoutine clinical practiceNovel outcome measuresPain etiologyBaseline characteristicsPain trialsPathophysiological mechanismsClinical trialsTreatment successTherapeutic approachesAnimal modelsPatient stratificationTreatment efficacyPainHuman painTherapeutic compoundsPatients