2023
Lessons learned in translating pain knowledge into practice
Becker J, Effraim P, Dib-Hajj S, Rittner H. Lessons learned in translating pain knowledge into practice. PAIN Reports 2023, 8: e1100. PMID: 37928204, PMCID: PMC10624476, DOI: 10.1097/pr9.0000000000001100.Peer-Reviewed Original ResearchPain knowledgeCalcitonin gene-related peptide antagonistsGrowth factorNovel pain treatmentsClinical phase IISevere side effectsMechanisms of nociceptionBetter preclinical modelsNeuronal growth factorsHands of cliniciansLack of effectMore patientsMusculoskeletal painPain treatmentChronic painClinical updateNew analgesicsClinical trialsNeurokinin receptorsPreclinical modelsPreclinical studiesSide effectsPatientsJoint replacementAvailable evidenceGenetic Profiling of Sodium Channels in Diabetic Painful and Painless and Idiopathic Painful and Painless Neuropathies
Almomani R, Sopacua M, Marchi M, Ślęczkowska M, Lindsey P, de Greef B, Hoeijmakers J, Salvi E, Merkies I, Ferdousi M, Malik R, Ziegler D, Derks K, Boenhof G, Martinelli-Boneschi F, Cazzato D, Lombardi R, Dib-Hajj S, Waxman S, Smeets H, Gerrits M, Faber C, Lauria G, Group O. Genetic Profiling of Sodium Channels in Diabetic Painful and Painless and Idiopathic Painful and Painless Neuropathies. International Journal Of Molecular Sciences 2023, 24: 8278. PMID: 37175987, PMCID: PMC10179245, DOI: 10.3390/ijms24098278.Peer-Reviewed Original ResearchConceptsDiabetic peripheral neuropathySmall fiber neuropathyPainless neuropathySFN patientsPainful neuropathyPeripheral neuropathyNeuropathy patientsPainless diabetic peripheral neuropathyPathogenic variantsPersonalized pain treatmentPainful peripheral neuropathyDifferent pathogenic variantsGenetic profilingSodium channel genePotential pathogenic variantsDPN patientsNeuropathic painNociceptive pathwaysPain treatmentNeuropathyPatientsSodium channelsFrequent featureDifferent centersSCN7A
2018
Differential aging‐related changes in neurophysiology and gene expression in IB4‐positive and IB4‐negative nociceptive neurons
Mis MA, Rogers MF, Jeffries AR, Wilbrey AL, Chen L, Yang Y, Dib‐Hajj S, Waxman SG, Stevens EB, Randall AD. Differential aging‐related changes in neurophysiology and gene expression in IB4‐positive and IB4‐negative nociceptive neurons. Aging Cell 2018, 17: e12795. PMID: 29943484, PMCID: PMC6052481, DOI: 10.1111/acel.12795.Peer-Reviewed Original ResearchConceptsIB4-negative neuronsIB4-positive neuronsIsolectin B4Age-dependent changesTTX-resistant sodium currentsProperties of nociceptorsDorsal root gangliaCurrent-clamp experimentsAging-related changesMiddle-aged rodentsHigh input resistancePain prevalenceNociceptive neuronsPain treatmentNociceptor excitabilityMembrane potentialPain sensitivityRoot gangliaCultured neuronsNeurons pointsRepetitive firingSodium currentWindow currentNociceptorsNeurons