Wound-healing growth factor, basic FGF, induces Erk1/2-dependent mechanical hyperalgesia
Andres C, Hasenauer J, Ahn H, Joseph EK, Isensee J, Theis FJ, Allgöwer F, Levine JD, Dib-Hajj S, Waxman SG, Hucho T. Wound-healing growth factor, basic FGF, induces Erk1/2-dependent mechanical hyperalgesia. Pain 2013, 154: 2216-2226. PMID: 23867734, DOI: 10.1016/j.pain.2013.07.005.Peer-Reviewed Original ResearchConceptsWound-healing factorsBasic fibroblast growth factorDorsal root gangliaDRG neuronsNociceptive neuronsGrowth factorMechanical hyperalgesiaPain sensitizationGlial cell line-derived neurotrophic factorRat dorsal root gangliaLine-derived neurotrophic factorSingle-cell electrophysiological recordingsLumbar DRG neuronsTranscription-polymerase chain reactionNerve growth factorWound healing growth factorsFibroblast growth factorTime-dependent mannerNeurotrophic factorRoot gangliaPolymerase chain reactionIntradermal injectionNav1.8 channelsBFGF treatmentElectrophysiological recordings