2023
Conserved but not critical: Trafficking and function of NaV1.7 are independent of highly conserved polybasic motifs
Tyagi S, Sarveswaran N, Higerd-Rusli G, Liu S, Dib-Hajj F, Waxman S, Dib-Hajj S. Conserved but not critical: Trafficking and function of NaV1.7 are independent of highly conserved polybasic motifs. Frontiers In Molecular Neuroscience 2023, 16: 1161028. PMID: 37008789, PMCID: PMC10060856, DOI: 10.3389/fnmol.2023.1161028.Peer-Reviewed Original ResearchSensory axonsPeripheral voltage-gated sodium channelsMajor unmet clinical needFunction of Nav1.7Non-addictive treatmentsUnmet clinical needVoltage-clamp recordingsVoltage-gated sodium channelsPain therapyChronic painPrimary afferentsNoxious stimuliTherapeutic modalitiesAction potentialsAxonal transportClinical needVesicular packagingSodium channelsHuman painPainAxonal traffickingAxonal surfaceAxonal membraneAxonsAttractive target
2022
Maximizing treatment efficacy through patient stratification in neuropathic pain trials
Baron R, Dickenson A, Calvo M, Dib-Hajj S, Bennett D. Maximizing treatment efficacy through patient stratification in neuropathic pain trials. Nature Reviews Neurology 2022, 19: 53-64. PMID: 36400867, DOI: 10.1038/s41582-022-00741-7.Peer-Reviewed Original ResearchConceptsNeuropathic painPain medicineOutcome measuresClinical practiceNeuropathic pain etiologyNeuropathic pain trialsPatient stratification approachesMultiple pathophysiological mechanismsSubgrouping of patientsRoutine clinical practiceNovel outcome measuresPain etiologyBaseline characteristicsPain trialsPathophysiological mechanismsClinical trialsTreatment successTherapeutic approachesAnimal modelsPatient stratificationTreatment efficacyPainHuman painTherapeutic compoundsPatients