Role of hippocampal sodium channel Nav1.6 in kindling epileptogenesis
Blumenfeld H, Lampert A, Klein JP, Mission J, Chen MC, Rivera M, Dib‐Hajj S, Brennan AR, Hains BC, Waxman SG. Role of hippocampal sodium channel Nav1.6 in kindling epileptogenesis. Epilepsia 2009, 50: 44-55. PMID: 18637833, PMCID: PMC3741044, DOI: 10.1111/j.1528-1167.2008.01710.x.Peer-Reviewed Original ResearchConceptsHippocampal CA3 neuronsActivity-dependent facilitationCA3 neuronsCommon nervous system disordersSodium channel protein expressionSodium currentCentral nervous system plasticityChannel messenger RNAExpression of Nav1.6Sham-kindled controlsSodium channel Nav1.6Development of kindlingNervous system plasticityNervous system disordersWild-type miceRate of kindlingChannel protein expressionMessenger RNAPatch-clamp recordingsActivity-dependent plasticityPersistent sodium currentIon channel expressionNormal hippocampal functionAction potential generationAbnormal plasticity