2014
Gut Microbiota of the Tick Vector Ixodes scapularis Modulate Colonization of the Lyme Disease Spirochete
Narasimhan S, Rajeevan N, Liu L, Zhao YO, Heisig J, Pan J, Eppler-Epstein R, DePonte K, Fish D, Fikrig E. Gut Microbiota of the Tick Vector Ixodes scapularis Modulate Colonization of the Lyme Disease Spirochete. Cell Host & Microbe 2014, 15: 58-71. PMID: 24439898, PMCID: PMC3905459, DOI: 10.1016/j.chom.2013.12.001.Peer-Reviewed Original ResearchConceptsPeritrophic matrixTranscription factor signal transducerPathogen colonizationLyme disease spirochete Borrelia burgdorferiActivator of transcriptionGut microbiotaArthropod gutsSignal transducerLyme disease spirocheteFunctional linkArthropod vectorsMajor vectorKey glycoproteinsHuman pathogensSpirochete Borrelia burgdorferiGut epitheliumIxodes scapularis ticksColonizationGut epithelial barrierMicrobiotaExpressionGut lumenScapularis ticksBorrelia burgdorferiEpithelial barrier
2011
A Tick Mannose-Binding Lectin Inhibitor Interferes with the Vertebrate Complement Cascade to Enhance Transmission of the Lyme Disease Agent
Schuijt TJ, Coumou J, Narasimhan S, Dai J, DePonte K, Wouters D, Brouwer M, Oei A, Roelofs JJ, van Dam AP, van der Poll T, Veer C, Hovius JW, Fikrig E. A Tick Mannose-Binding Lectin Inhibitor Interferes with the Vertebrate Complement Cascade to Enhance Transmission of the Lyme Disease Agent. Cell Host & Microbe 2011, 10: 136-146. PMID: 21843870, PMCID: PMC3170916, DOI: 10.1016/j.chom.2011.06.010.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBorrelia burgdorferiCell Migration AssaysCloning, MolecularComplement Membrane Attack ComplexComplement Pathway, Mannose-Binding LectinFemaleGene SilencingHemolysisHumansImmunization, PassiveImmunotherapy, ActiveInsect ProteinsIxodesLarvaLyme DiseaseMiceMice, Inbred C3HMolecular Sequence DataNeutrophilsNymphPhagocytosisRabbitsRecombinant ProteinsSalivaSalivary Proteins and PeptidesSequence AlignmentConceptsComplement cascadeLyme disease agent Borrelia burgdorferiImpaired neutrophil phagocytosisTick salivary proteinsVector-borne pathogensLyme disease agentMammalian infectionVector colonizationVertebrate hostsTick midgutAlternative complement pathwayBorrelia transmissionComplement-mediated killingVector proteinNeutrophil phagocytosisEssential rolePathway inhibitorComplement pathwayDisease agentsSalivary proteinsBorrelia burgdorferiLectin inhibitorsProteinCascadeIxodes ticks
1999
Ancylostoma secreted protein 2: cloning and characterization of a second member of a family of nematode secreted proteins from Ancylostoma caninum
Hawdon J, Narasimhan S, Hotez P. Ancylostoma secreted protein 2: cloning and characterization of a second member of a family of nematode secreted proteins from Ancylostoma caninum. Molecular And Biochemical Parasitology 1999, 99: 149-165. PMID: 10340481, DOI: 10.1016/s0166-6851(99)00011-0.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAncylostomaAncylostomatoideaAnimalsAntibodies, HelminthAntibody SpecificityAspartic Acid EndopeptidasesBase SequenceBlotting, SouthernBlotting, WesternCloning, MolecularDNA, HelminthDogsGenes, HelminthHelminth ProteinsLarvaMolecular Sequence DataRecombinant ProteinsSequence AlignmentConceptsHost-specific signalsLife history stagesFamilies of nematodesEarly eventsNematode physiologyHistory stagesHookworm Ancylostoma caninumParasitic speciesCDNA encodesCDNA libraryParasitic nematodesGene productsDevelopmental eventsInfective third-stage larvaeDiverse familyNematodesAmino acidsExcretory/secretory productsProtein 2ProteinSpecific signalsDatabase searchingAncylostoma caninumThird-stage larvaeImportant functions
1997
Vaccines for hookworm infection
HOTEZ P, GHOSH K, HAWDON J, NARASIMHAN S, JONES B, BETHONY J. Vaccines for hookworm infection. The Pediatric Infectious Disease Journal 1997, 16: 935-940. PMID: 9380467, DOI: 10.1097/00006454-199710000-00006.Peer-Reviewed Original Research
1992
Hyaluronidase from infective Ancylostoma hookworm larvae and its possible function as a virulence factor in tissue invasion and in cutaneous larva migrans
Hotez P, Narasimhan S, Haggerty J, Milstone L, Bhopale V, Schad G, Richards F. Hyaluronidase from infective Ancylostoma hookworm larvae and its possible function as a virulence factor in tissue invasion and in cutaneous larva migrans. Infection And Immunity 1992, 60: 1018-1023. PMID: 1541516, PMCID: PMC257588, DOI: 10.1128/iai.60.3.1018-1023.1992.Peer-Reviewed Original Research