1999
Experimental approaches to the development of a recombinant hookworm vaccine
Hotez P, Ghosh K, Huwdon J, Narasimhan S, Jones B, Shuhua X, Sen L, Bin Z, Haechou X, Hainan R, Heng W, Koski R. Experimental approaches to the development of a recombinant hookworm vaccine. Immunological Reviews 1999, 171: 163-171. PMID: 10582170, DOI: 10.1111/j.1600-065x.1999.tb01347.x.Peer-Reviewed Original ResearchConceptsHookworm infectionHeavy hookworm infectionMajor parasitic causeHookworm antigensSerologic correlatesVaccine protectionChallenge infectionHookworm burdenHookworm vaccineParasitic causesEndemic areasHuman infectionsInfectionLaboratory animalsVaccineAlum precipitateMorbidityRecombinant polypeptidesHookwormAntigenDiseaseMiceImmunityAntibodiesAncylostoma secreted protein 2: cloning and characterization of a second member of a family of nematode secreted proteins from Ancylostoma caninum
Hawdon J, Narasimhan S, Hotez P. Ancylostoma secreted protein 2: cloning and characterization of a second member of a family of nematode secreted proteins from Ancylostoma caninum. Molecular And Biochemical Parasitology 1999, 99: 149-165. PMID: 10340481, DOI: 10.1016/s0166-6851(99)00011-0.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAncylostomaAncylostomatoideaAnimalsAntibodies, HelminthAntibody SpecificityAspartic Acid EndopeptidasesBase SequenceBlotting, SouthernBlotting, WesternCloning, MolecularDNA, HelminthDogsGenes, HelminthHelminth ProteinsLarvaMolecular Sequence DataRecombinant ProteinsSequence AlignmentConceptsHost-specific signalsLife history stagesFamilies of nematodesEarly eventsNematode physiologyHistory stagesHookworm Ancylostoma caninumParasitic speciesCDNA encodesCDNA libraryParasitic nematodesGene productsDevelopmental eventsInfective third-stage larvaeDiverse familyNematodesAmino acidsExcretory/secretory productsProtein 2ProteinSpecific signalsDatabase searchingAncylostoma caninumThird-stage larvaeImportant functions
1992
Hyaluronidase from infective Ancylostoma hookworm larvae and its possible function as a virulence factor in tissue invasion and in cutaneous larva migrans
Hotez P, Narasimhan S, Haggerty J, Milstone L, Bhopale V, Schad G, Richards F. Hyaluronidase from infective Ancylostoma hookworm larvae and its possible function as a virulence factor in tissue invasion and in cutaneous larva migrans. Infection And Immunity 1992, 60: 1018-1023. PMID: 1541516, PMCID: PMC257588, DOI: 10.1128/iai.60.3.1018-1023.1992.Peer-Reviewed Original Research