2022
The environment, the tick, and the pathogen – It is an ensemble
Couret J, Schofield S, Narasimhan S. The environment, the tick, and the pathogen – It is an ensemble. Frontiers In Cellular And Infection Microbiology 2022, 12: 1049646. PMID: 36405964, PMCID: PMC9666722, DOI: 10.3389/fcimb.2022.1049646.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTick-pathogen interactionsCritical environmental factorsBiotic factorsAbiotic factorsMammalian hostsEnvironmental microbiotaTick biologyEnsemble of interactionsMolecular understandingMolecular studiesGeographic distributionNorthcentral USAPathogen acquisitionTick-borne diseasesBiologyNew insightsEnvironmental factorsPredominant vectorLyme diseaseTicksInfection prevalenceInteractionPublic health problemPathogensHost
2021
Tick immunity using mRNA, DNA and protein-based Salp14 delivery strategies
Matias J, Kurokawa C, Sajid A, Narasimhan S, Arora G, Diktas H, Lynn GE, DePonte K, Pardi N, Valenzuela JG, Weissman D, Fikrig E. Tick immunity using mRNA, DNA and protein-based Salp14 delivery strategies. Vaccine 2021, 39: 7661-7668. PMID: 34862075, PMCID: PMC8671329, DOI: 10.1016/j.vaccine.2021.11.003.Peer-Reviewed Original ResearchConceptsTick bite siteTick immunityAntigen deliveryBite siteGuinea pigsDevelopment of vaccinesIxodes scapularis ticksProtein immunizationAntibody responseTick biteVaccine platformLipid nanoparticlesMRNA lipid nanoparticlesMRNA-LNPModel antigenTick salivaEarly hallmarkImmunityTick-borne diseasesScapularis ticksTick challengeErythemaSalivary componentsFactor XaDelivery strategiesPotential impacts of climate change on medically important tick species in North America.
Lynn G, Narasimhan S, Fikrig E. Potential impacts of climate change on medically important tick species in North America. 2021, 145-151. DOI: 10.1079/9781789249637.0021.Chapters