2020
Repeat tick exposure elicits distinct immune responses in guinea pigs and mice
Kurokawa C, Narasimhan S, Vidyarthi A, Booth CJ, Mehta S, Meister L, Diktas H, Strank N, Lynn GE, DePonte K, Craft J, Fikrig E. Repeat tick exposure elicits distinct immune responses in guinea pigs and mice. Ticks And Tick-borne Diseases 2020, 11: 101529. PMID: 32993942, PMCID: PMC7530331, DOI: 10.1016/j.ttbdis.2020.101529.Peer-Reviewed Original ResearchConceptsGuinea pigsElicit distinct immune responsesDistinct immune responsesGuinea pig modelLocal blood flowImmune animalsInflammatory pathwaysTick rejectionMechanisms of resistanceImmune responseMouse modelVaccine candidatesBite siteBlood flowPig modelCoagulation pathwayComplement activationAcquired ResistanceProtective antigenTick detachmentTick proteinsBlood mealMiceTick infestationRNA sequencing
1999
Experimental approaches to the development of a recombinant hookworm vaccine
Hotez P, Ghosh K, Huwdon J, Narasimhan S, Jones B, Shuhua X, Sen L, Bin Z, Haechou X, Hainan R, Heng W, Koski R. Experimental approaches to the development of a recombinant hookworm vaccine. Immunological Reviews 1999, 171: 163-171. PMID: 10582170, DOI: 10.1111/j.1600-065x.1999.tb01347.x.Peer-Reviewed Original ResearchConceptsHookworm infectionHeavy hookworm infectionMajor parasitic causeHookworm antigensSerologic correlatesVaccine protectionChallenge infectionHookworm burdenHookworm vaccineParasitic causesEndemic areasHuman infectionsInfectionLaboratory animalsVaccineAlum precipitateMorbidityRecombinant polypeptidesHookwormAntigenDiseaseMiceImmunityAntibodies