2024
DECIPHERING THE UNDERLYING BIOLOGY OF PSYCHIATRIC DISORDERS THROUGH LONGITUDINAL FAMILY COHORT BASED STUDIES IN INDIA
Viswanath B, Sud R, Ganesh S, Mahadevan J, Holla B, Paul P, Purushottam M, Jain S, Consortium A. DECIPHERING THE UNDERLYING BIOLOGY OF PSYCHIATRIC DISORDERS THROUGH LONGITUDINAL FAMILY COHORT BASED STUDIES IN INDIA. European Neuropsychopharmacology 2024, 87: 43-44. DOI: 10.1016/j.euroneuro.2024.08.108.Peer-Reviewed Original ResearchAdverse childhood eventsWhole-exome sequencingFirst-degree relativesChildhood eventsStudies of psychiatric disordersFamily history densityObsessive compulsive disorderGenetic studies of psychiatric disordersSubstance use disordersPeripheral blood mononuclear cellsSevere mental illnessLongitudinal family cohortGenetic studiesAge-of-onsetTransdiagnostic endophenotypesBrain imaging abnormalitiesCompulsive disorderBipolar disorderPsychiatric diagnosisPsychiatric disordersMultiple affected membersCognitive performanceRare damaging variantsMental illnessCognitive AssessmentF67. CHARACTERIZING THE IMPACT OF AUTOZYGOSITY AND RUNS OF HOMOZYGOSITY ON PSYCHIATRIC DISEASE RISK IN INDIAN POPULATION
Kandasamy K, Ganesh S, Sachdeva P, Mahadevan J, Holla B, Benegal V, Purushottam M, Jain S, Viswanath B. F67. CHARACTERIZING THE IMPACT OF AUTOZYGOSITY AND RUNS OF HOMOZYGOSITY ON PSYCHIATRIC DISEASE RISK IN INDIAN POPULATION. European Neuropsychopharmacology 2024, 87: 242. DOI: 10.1016/j.euroneuro.2024.08.478.Peer-Reviewed Original ResearchGenetic architecture of psychiatric disordersIllumina Global Screening ArrayGlobal Screening ArrayContinental populationsGenetic architectureInbreeding coefficientRecessive locusAutozygosityFROHObsessive compulsive disorderScreening ArrayPLINK v.GenomeInbreedingBipolar disorderDisease-riskPsychiatric diagnosisPsychiatric disordersDisease riskEndogamyIlluminaCase-control differencesLociPLINKROH
2020
Adverse childhood experiences in families with multiple members diagnosed to have psychiatric illnesses
Someshwar A, Holla B, Pansari Agarwal P, Thomas A, Jose A, Joseph B, Raju B, Karle H, Muthukumaran M, Kodancha P, Kumar P, Reddy P, Kumar Nadella R, Naik S, Mitra S, Mallappagiri S, Sreeraj V, Balachander S, Ganesh S, Murthy P, Benegal V, Reddy J, Jain S, Mahadevan J, Viswanath B, Rao N, Narayanaswamy J, Sivakumar P, Kandasamy A, Kesavan M, Mehta U, Venkatasubramanian G, John J, Mukherjee O, Purushottam M, Kannan R, Mehta B, Kandavel T, Binukumar B, Saini J, Jayarajan D, Shyamsundar A, Moirangthem S, Vijay Kumar K, Thirthalli J, Chandra P, Gangadhar B, Panicker M, Bhalla U, Chattarji S, Varghese M, Raghu P, Rao M. Adverse childhood experiences in families with multiple members diagnosed to have psychiatric illnesses. Australian & New Zealand Journal Of Psychiatry 2020, 54: 1086-1094. PMID: 32538179, DOI: 10.1177/0004867420931157.Peer-Reviewed Original ResearchConceptsFirst-degree relativesAdverse childhood experience exposureMajor psychiatric conditionsAdverse childhood experiencesObsessive-compulsive disorderSeverity scorePsychiatric conditionsSubstance dependencePsychiatric illnessBipolar disorderAdverse Childhood Experiences International QuestionnaireRisk first-degree relativesChildhood experiencesCo-occurring diagnosesAge of onsetEarly ageInteraction of diagnosisOngoing longitudinal studyPsychiatric diagnosis