2018
Predictive Low-Glucose Suspend Reduces Hypoglycemia in Adults, Adolescents, and Children With Type 1 Diabetes in an At-Home Randomized Crossover Study: Results of the PROLOG Trial
Forlenza GP, Li Z, Buckingham BA, Pinsker JE, Cengiz E, Wadwa RP, Ekhlaspour L, Church MM, Weinzimer SA, Jost E, Marcal T, Andre C, Carria L, Swanson V, Lum JW, Kollman C, Woodall W, Beck RW. Predictive Low-Glucose Suspend Reduces Hypoglycemia in Adults, Adolescents, and Children With Type 1 Diabetes in an At-Home Randomized Crossover Study: Results of the PROLOG Trial. Diabetes Care 2018, 41: dc180771. PMID: 30089663, DOI: 10.2337/dc18-0771.Peer-Reviewed Original ResearchConceptsType 1 diabetesSAP armPredictive low glucose suspendSensor-augmented pump therapyNew insulin delivery systemsRandomized Crossover StudySevere hypoglycemic eventsGlucose concentrationMin/dayMean glucose concentrationLow glucose suspendBasal-IQRebound hyperglycemiaSlim X2Glycemic controlPrimary outcomeCrossover studyMedian timeCrossover trialHypoglycemic eventsPump therapyInsulin delivery systemsPercentage of timeHypoglycemiaDiabetes
2009
The Effect of Continuous Glucose Monitoring in Well-Controlled Type 1 Diabetes
Beck R, Hirsch I, Laffel L, Tamborlane W, Bode B, Buckingham B, Chase P, Clemons R, Fiallo-Scharer R, Fox L, Gilliam L, Huang E, Kollman C, Kowalski A, Lawrence J, Lee J, Mauras N, O'Grady M, Ruedy K, Tansey M, Tsalikian E, Weinzimer S, Wilson D, Wolpert H, Wysocki T, Xing D. The Effect of Continuous Glucose Monitoring in Well-Controlled Type 1 Diabetes. Diabetes Care 2009, 32: 1378-1383. PMID: 19429875, PMCID: PMC2713649, DOI: 10.2337/dc09-0108.Peer-Reviewed Original ResearchConceptsType 1 diabetesContinuous glucose monitoringSevere hypoglycemic eventsCGM groupControl groupHypoglycemic eventsGlucose monitoringGlucose levelsSignificant treatment group differencesMain study outcomeManagement of adultsTreatment group differencesMin/dayStandard glucose monitoringMean A1CA1c levelsMedian timeOutcome measuresA1CBiochemical hypoglycemiaMost outcomesType 1Hypoglycemia dataStudy outcomesDiabetes