Physiological calcium combined with electrical pacing accelerates maturation of human engineered heart tissue
Shen S, Sewanan LR, Shao S, Halder SS, Stankey P, Li X, Campbell SG. Physiological calcium combined with electrical pacing accelerates maturation of human engineered heart tissue. Stem Cell Reports 2022, 17: 2037-2049. PMID: 35931080, PMCID: PMC9481907, DOI: 10.1016/j.stemcr.2022.07.006.Peer-Reviewed Original ResearchMeSH KeywordsCalciumCell DifferentiationHumansInduced Pluripotent Stem CellsMyocytes, CardiacTissue EngineeringConceptsHuman-induced pluripotent stem cell-derived cardiomyocytesWide potential applicationsRegenerative medicineScalable platformElectrical pacingPotential applicationsForce-frequency behaviorCardiac troponin IPluripotent stem cell-derived cardiomyocytesStem cell-derived cardiomyocytesAdrenergic responseCell-derived cardiomyocytesFunctional maturationHiPSC-CM maturationTroponin IClinical researchTwitch kineticsHeart tissuePhysiological CaPacingPhysiological calciumApplicationsBasic researchRole of CaMaturation