2018
Fat and Bone: PGC-1α Regulates Mesenchymal Cell Fate during Aging and Osteoporosis
Horowitz MC, Tommasini SM. Fat and Bone: PGC-1α Regulates Mesenchymal Cell Fate during Aging and Osteoporosis. Cell Stem Cell 2018, 23: 151-153. PMID: 30075123, DOI: 10.1016/j.stem.2018.07.010.Peer-Reviewed Original Research
2016
Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module
Calabrese GM, Mesner LD, Stains JP, Tommasini SM, Horowitz MC, Rosen CJ, Farber CR. Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module. Cell Systems 2016, 4: 46-59.e4. PMID: 27866947, PMCID: PMC5269473, DOI: 10.1016/j.cels.2016.10.014.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone and BonesBone DensityChromosome MappingGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMiceMice, Inbred C57BLMice, KnockoutOsteoblastsOsteoporosisOsteoporotic FracturesPhenotypePolymorphism, Single NucleotideProtein Serine-Threonine KinasesSpectrinTranscriptomeConceptsGenome-wide association studiesCo-expression networkGWAS lociCausal genesBMD genome-wide association studiesIntegrating Genome-Wide Association StudyBMD GWAS lociGWAS associationsMapping genesGWAS dataAssociation studiesGenesLociFunctional modulesHeritable predictorSPTBN1Most associationsWide range
2011
Changes in intracortical microporosities induced by pharmaceutical treatment of osteoporosis as detected by high resolution micro-CT
Tommasini SM, Trinward A, Acerbo AS, De Carlo F, Miller LM, Judex S. Changes in intracortical microporosities induced by pharmaceutical treatment of osteoporosis as detected by high resolution micro-CT. Bone 2011, 50: 596-604. PMID: 22226688, PMCID: PMC3278519, DOI: 10.1016/j.bone.2011.12.012.Peer-Reviewed Original ResearchConceptsAge-matched controlsUntreated OVXEstrogen withdrawalSix-month-old female SpragueDifferent osteoporosis treatmentsUntreated OVX ratsStart of treatmentEndosteal regionOsteocyte lacunar sizeEffect of treatmentOVX ratsOsteoporosis treatmentFemale SpraguePTH treatmentDawley ratsCurrent treatmentNumber of lacunaeMedial cortexOsteocyte lacunaePharmaceutical treatmentOVXMedial quadrantAlendronateBone strengthFemoral diaphysis