2024
Mitofusin 2 plays a critical role in maintaining the functional integrity of the neuromuscular-skeletal axis
Zhu M, Zeiss C, Hamrick M, Weinstein R, Sun B, Brotto M, Liu X, Siu E, Huttner A, Tommasini S, Simpson C, Insogna K. Mitofusin 2 plays a critical role in maintaining the functional integrity of the neuromuscular-skeletal axis. Bone 2024, 184: 117086. PMID: 38552893, DOI: 10.1016/j.bone.2024.117086.Peer-Reviewed Original ResearchConceptsDeletion of Mfn2Bone mineral densityMitofusin 2Reduced expression of Mfn2Myofiber atrophySpinal cordTransgenic mice expressing CreMice expressing CreNon-redundant roleSkeletal muscle histologyLumbar spinal cordTrabecular bone massLean body massExpression of Mfn2Mitochondrial reticulumMFN2 geneDisruption of cellular architectureImpaired osteoblast differentiationOsteoblast lineage commitmentMfn2Mitochondrial sizeMitofusinMineral densityCo-expressionDisorganized sarcomeres
2017
Ibuprofen impairs capsulolabral healing in a rat model of anterior glenohumeral instability
Packer JD, Varthi AG, Zhu DS, Javier FG, Young JD, Garver JV, Henry H, Tommasini SM, Blaine TA. Ibuprofen impairs capsulolabral healing in a rat model of anterior glenohumeral instability. Journal Of Shoulder And Elbow Surgery 2017, 27: 315-324. PMID: 29195899, DOI: 10.1016/j.jse.2017.09.027.Peer-Reviewed Original ResearchConceptsNonsteroidal anti-inflammatory drugsNSAID groupGlenohumeral dislocationRat modelControl groupUninjured limbUse of NSAIDsGlenohumeral instabilityGlenoid labrumAnterior glenohumeral dislocationAnterior-inferior labral tearsAnterior glenohumeral instabilityAnti-inflammatory drugsMatched pair analysisNew rat modelPersistent shoulder instabilityCapsular healingPostinjury administrationInjured limbImpaired healingLabral tearsHistologic analysisShoulder instabilityGlenohumeral stabilityBiomechanical testing
2016
Novel anatomic adaptation of cortical bone to meet increased mineral demands of reproduction
Macica CM, King HE, Wang M, McEachon CL, Skinner CW, Tommasini SM. Novel anatomic adaptation of cortical bone to meet increased mineral demands of reproduction. Bone 2016, 85: 59-69. PMID: 26825813, PMCID: PMC7429445, DOI: 10.1016/j.bone.2015.12.056.Peer-Reviewed Original ResearchConceptsHyp miceMineral homeostasisElevated serum PTHMaternal bone massMineralized trabecular boneIntestinal calcium absorptionCortical boneWild-type miceSerum PTHCalcitriol productionFemale patientsMaternal skeletonPostnatal nutritionCalcium absorptionBone resorptionFracture riskMaternal adaptationBone massBone fragilityMurine modelIntracortical porosityUnaffected miceMouse modelMMP-13Fetal development
2015
Periosteal PTHrP Regulates Cortical Bone Remodeling During Fracture Healing
Wang M, Nasiri AR, Broadus AE, Tommasini SM. Periosteal PTHrP Regulates Cortical Bone Remodeling During Fracture Healing. Bone 2015, 81: 104-111. PMID: 26164475, PMCID: PMC4641003, DOI: 10.1016/j.bone.2015.07.008.Peer-Reviewed Original ResearchConceptsFracture healingPTHrP expressionCKO miceCortical bone surfaceFracture repairTibial fracture surgeryRole of PTHrPHormone-related proteinTibial fracture modelCartilaginous callus formationConditional knockout miceBone surfaceCortical bone remodelingType I receptorCD1 controlsFracture surgeryCD1 miceKnockout miceInitial genetic evidencePTHrPOsteoblastic activityBone remodelingMiceBone mineralizationI receptor
2012
Genetic variations and physical activity as determinants of limb bone morphology: An experimental approach using a mouse model
Wallace IJ, Tommasini SM, Judex S, Garland T, Demes B. Genetic variations and physical activity as determinants of limb bone morphology: An experimental approach using a mouse model. American Journal Of Biological Anthropology 2012, 148: 24-35. PMID: 22331623, DOI: 10.1002/ajpa.22028.Peer-Reviewed Original Research
2008
Biological Co‐Adaptation of Morphological and Composition Traits Contributes to Mechanical Functionality and Skeletal Fragility1*
Tommasini SM, Nasser P, Hu B, Jepsen KJ. Biological Co‐Adaptation of Morphological and Composition Traits Contributes to Mechanical Functionality and Skeletal Fragility1*. Journal Of Bone And Mineral Research 2008, 23: 236-246. PMID: 17922614, PMCID: PMC2665697, DOI: 10.1359/jbmr.071014.Peer-Reviewed Original Research
2007
Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility
Jepsen KJ, Hu B, Tommasini SM, Courtland HW, Price C, Terranova CJ, Nadeau JH. Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility. Mammalian Genome 2007, 18: 492-507. PMID: 17557179, PMCID: PMC1998883, DOI: 10.1007/s00335-007-9017-5.Peer-Reviewed Original ResearchConceptsFunctional interactionMean trait valuesRI strainsCombination of traitsTrait valuesGenomic regionsCellular processesLoss of functionBone slendernessGenetic variabilityEnvironmental perturbationsSkeletal traitsAXB/BXAImportant functional interactionTraitsBiological paradigmBone traitsFunctional relationshipMouse strainsGenetic randomizationAdult malesHigher mineral densityStrainsUnique setGrowth
2006
Sexual dimorphism affects tibia size and shape but not tissue-level mechanical properties
Tommasini SM, Nasser P, Jepsen KJ. Sexual dimorphism affects tibia size and shape but not tissue-level mechanical properties. Bone 2006, 40: 498-505. PMID: 17035111, DOI: 10.1016/j.bone.2006.08.012.Peer-Reviewed Original Research
2005
Relationship Between Bone Morphology and Bone Quality in Male Tibias: Implications for Stress Fracture Risk*
Tommasini SM, Nasser P, Schaffler MB, Jepsen KJ. Relationship Between Bone Morphology and Bone Quality in Male Tibias: Implications for Stress Fracture Risk*. Journal Of Bone And Mineral Research 2005, 20: 1372-1380. PMID: 16007335, DOI: 10.1359/jbmr.050326.Peer-Reviewed Original ResearchConceptsStress fracture riskYears of ageFracture riskBone sizeTissue-level mechanical propertiesStress fracturesNew prevention strategiesMale military recruitsBone morphologySlender bonesMedial-lateral widthNarrower tibiaeFracture incidenceBone quality parametersMales 17Tissue fragilityTibial diaphysisAnimal modelsBody weightPrevention strategiesBone qualityMilitary recruitsSection modulusCortical tissueMale athletes