2023
An analytical model of lateral condylar plate working length
Roytman G, Beitler B, LaMonica J, Spero M, Toy K, Ramji A, Yoo B, Leslie M, Baumgaertner M, Tommasini S, Wiznia D. An analytical model of lateral condylar plate working length. Clinical Biomechanics 2023, 110: 106129. PMID: 37871506, PMCID: PMC10848195, DOI: 10.1016/j.clinbiomech.2023.106129.Peer-Reviewed Original ResearchSome Offset Restoration Options Can Paradoxically Lead to Decreased Range of Motion in Primary Total Hip Arthroplasty: A 3-Dimensional Computer Simulation Study
Pour A, Donnelley C, Tung W, Tommasini S, Wiznia D. Some Offset Restoration Options Can Paradoxically Lead to Decreased Range of Motion in Primary Total Hip Arthroplasty: A 3-Dimensional Computer Simulation Study. The Journal Of Arthroplasty 2023, 39: 514-519.e3. PMID: 37625464, PMCID: PMC10843541, DOI: 10.1016/j.arth.2023.08.057.Peer-Reviewed Original ResearchConceptsTotal hip arthroplastyRange of motionPrimary total hip arthroplastyHip flexionHip arthroplastyParadoxical increaseHigh-offset stemsRobotic arm-assisted total hip arthroplastyGroup of patientsSubset of patientsSagittal pelvic tiltVarus neckMaximum internal rotationPelvic tiltOptimizing outcomesImplant design featuresDecreased rangeHip extensionExternal rotationImplant choiceProsthetic headMaximum external rotationFlexionImpingement riskLiner useHip Abduction Can Be Considered the Sole Posterior Precaution Strategy to Lower the Rate of Impingement After Posterior Approach Total Hip Arthroplasty With Large Femoral Head: A Computer Simulation Study
Eslam Pour A, Tung W, Donnelley C, Tommasini S, Wiznia D. Hip Abduction Can Be Considered the Sole Posterior Precaution Strategy to Lower the Rate of Impingement After Posterior Approach Total Hip Arthroplasty With Large Femoral Head: A Computer Simulation Study. The Journal Of Arthroplasty 2023, 38: 1385-1391. PMID: 36709882, PMCID: PMC10257737, DOI: 10.1016/j.arth.2023.01.027.Peer-Reviewed Original ResearchConceptsTotal hip arthroplastyAnterior pelvic tilt angleHip abductionPelvic tilt angleHip arthroplastyHip precautionsPosterior approach total hip arthroplastyPrimary total hip arthroplastyAnterior inferior iliac spineLarger prosthetic headsHip internal rotationRisk of dislocationHip external rotationCup anteversion angleLarge femoral headsAbsolute riskBony impingementHip flexionIliac spineFemoral headExternal rotationProsthetic headAnteversion anglePatientsAcetabular implants
2022
How metal augments, polyethylene thickness and stem length affect tibial baseplate load transfer in revision total knee arthroplasty
LaMonica J, Pham N, Milligan K, Tommasini S, Schwarzkopf R, Parisi R, Wiznia D. How metal augments, polyethylene thickness and stem length affect tibial baseplate load transfer in revision total knee arthroplasty. The Knee 2022, 40: 283-291. PMID: 36529046, DOI: 10.1016/j.knee.2022.11.021.Peer-Reviewed Original Research
2018
Fat and Bone: PGC-1α Regulates Mesenchymal Cell Fate during Aging and Osteoporosis
Horowitz MC, Tommasini SM. Fat and Bone: PGC-1α Regulates Mesenchymal Cell Fate during Aging and Osteoporosis. Cell Stem Cell 2018, 23: 151-153. PMID: 30075123, DOI: 10.1016/j.stem.2018.07.010.Peer-Reviewed Original Research
2016
Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module
Calabrese GM, Mesner LD, Stains JP, Tommasini SM, Horowitz MC, Rosen CJ, Farber CR. Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module. Cell Systems 2016, 4: 46-59.e4. PMID: 27866947, PMCID: PMC5269473, DOI: 10.1016/j.cels.2016.10.014.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone and BonesBone DensityChromosome MappingGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMiceMice, Inbred C57BLMice, KnockoutOsteoblastsOsteoporosisOsteoporotic FracturesPhenotypePolymorphism, Single NucleotideProtein Serine-Threonine KinasesSpectrinTranscriptomeConceptsGenome-wide association studiesCo-expression networkGWAS lociCausal genesBMD genome-wide association studiesIntegrating Genome-Wide Association StudyBMD GWAS lociGWAS associationsMapping genesGWAS dataAssociation studiesGenesLociFunctional modulesHeritable predictorSPTBN1Most associationsWide range
2015
Deletion of Rac in Mature Osteoclasts Causes Osteopetrosis, an Age‐Dependent Change in Osteoclast Number, and a Reduced Number of Osteoblasts In Vivo
Zhu M, Sun B, Saar K, Simpson C, Troiano N, Dallas SL, Tiede‐Lewis L, Nevius E, Pereira JP, Weinstein RS, Tommasini SM, Insogna KL. Deletion of Rac in Mature Osteoclasts Causes Osteopetrosis, an Age‐Dependent Change in Osteoclast Number, and a Reduced Number of Osteoblasts In Vivo. Journal Of Bone And Mineral Research 2015, 31: 864-873. PMID: 26496249, PMCID: PMC4826801, DOI: 10.1002/jbmr.2733.Peer-Reviewed Original ResearchConceptsDual-energy X-ray absorptiometryBone mineral densityDKO miceParathyroid hormoneOsteoclast numberDKO animalsSerum cross-linked C-telopeptideCross-linked C-telopeptideDaily parathyroid hormoneTrabecular bone massX-ray absorptiometryMetaphyseal trabecular boneNormal differentiation markersAge-dependent changesC-telopeptideMineral densityBone massBone densityActin ring formationSkeletal metabolismOsteoblast numberTooth eruptionResorptive activityNormal responseFocal disruption
2008
Biological Co‐Adaptation of Morphological and Composition Traits Contributes to Mechanical Functionality and Skeletal Fragility1*
Tommasini SM, Nasser P, Hu B, Jepsen KJ. Biological Co‐Adaptation of Morphological and Composition Traits Contributes to Mechanical Functionality and Skeletal Fragility1*. Journal Of Bone And Mineral Research 2008, 23: 236-246. PMID: 17922614, PMCID: PMC2665697, DOI: 10.1359/jbmr.071014.Peer-Reviewed Original Research
2006
Sexual dimorphism affects tibia size and shape but not tissue-level mechanical properties
Tommasini SM, Nasser P, Jepsen KJ. Sexual dimorphism affects tibia size and shape but not tissue-level mechanical properties. Bone 2006, 40: 498-505. PMID: 17035111, DOI: 10.1016/j.bone.2006.08.012.Peer-Reviewed Original Research
2005
Relationship Between Bone Morphology and Bone Quality in Male Tibias: Implications for Stress Fracture Risk*
Tommasini SM, Nasser P, Schaffler MB, Jepsen KJ. Relationship Between Bone Morphology and Bone Quality in Male Tibias: Implications for Stress Fracture Risk*. Journal Of Bone And Mineral Research 2005, 20: 1372-1380. PMID: 16007335, DOI: 10.1359/jbmr.050326.Peer-Reviewed Original ResearchConceptsStress fracture riskYears of ageFracture riskBone sizeTissue-level mechanical propertiesStress fracturesNew prevention strategiesMale military recruitsBone morphologySlender bonesMedial-lateral widthNarrower tibiaeFracture incidenceBone quality parametersMales 17Tissue fragilityTibial diaphysisAnimal modelsBody weightPrevention strategiesBone qualityMilitary recruitsSection modulusCortical tissueMale athletes