2012
The role of inhibition in oscillatory wave dynamics in the cortex
Xiao Y, Huang X, Van Wert S, Barreto E, Wu J, Gluckman B, Schiff S. The role of inhibition in oscillatory wave dynamics in the cortex. European Journal Of Neuroscience 2012, 36: 2201-2212. PMID: 22805065, PMCID: PMC4410882, DOI: 10.1111/j.1460-9568.2012.08132.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBicucullineCarbacholEpilepsies, PartialGABA-A Receptor AgonistsGABA-A Receptor AntagonistsGABA-B Receptor AgonistsGABA-B Receptor AntagonistsMaleMembrane PotentialsModels, NeurologicalNeocortexNeural InhibitionPicrotoxinRatsRats, Sprague-DawleyReceptors, AMPAReceptors, GABA-AReceptors, GABA-BReceptors, N-Methyl-D-AspartateTheta RhythmConceptsGABAergic inhibitionNeocortical brain slicesVoltage-sensitive dye imagingSprague-Dawley ratsPresence of carbacholConcentration-dependent mannerGABAB antagonistGABAA receptorsBrain slicesTheta frequency oscillationsPharmacological methodsDye imagingCortical oscillationsRole of inhibitionBicucullineDisinhibitionGABAATheta oscillationsCortexBasic spatiotemporal patternsInhibitionNeural information processingCarbacholMental tasksAntagonist
2010
Assimilating Seizure Dynamics
Ullah G, Schiff S. Assimilating Seizure Dynamics. PLOS Computational Biology 2010, 6: e1000776. PMID: 20463875, PMCID: PMC2865517, DOI: 10.1371/journal.pcbi.1000776.Peer-Reviewed Original ResearchConceptsModern control theoryDynamics of networksDynamical systemsControl theoryUnmeasured partDynamical interactionsData assimilationSmall neuronal networksPhysical variablesDynamicsBrain dynamicsComputational modelSeizure dynamicsActual measurementsNeuronal networksMicroenvironment dynamicsObservabilityNetworkVariablesModelTheorySystemMeasurements
2009
The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states: I. Single neuron dynamics
Cressman J, Ullah G, Ziburkus J, Schiff S, Barreto E. The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states: I. Single neuron dynamics. Journal Of Computational Neuroscience 2009, 26: 159-170. PMID: 19169801, PMCID: PMC2704057, DOI: 10.1007/s10827-008-0132-4.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsDiffusionMembrane PotentialsModels, NeurologicalNeurogliaNeuronsPotassiumSeizuresSodiumSodium-Potassium-Exchanging ATPaseConceptsSingle neuron dynamicsDetailed bifurcation analysisLarge amplitude oscillationsExtracellular ion concentration dynamicsMathematical modelBifurcation analysisDynamical mechanismIon concentration dynamicsNeuron dynamicsReasonable approximationFull modelCompanion paperDynamicsImportant fundamental processesConcentration dynamics
2008
The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states: II. Network and glial dynamics
Ullah G, Cressman Jr. J, Barreto E, Schiff S. The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states: II. Network and glial dynamics. Journal Of Computational Neuroscience 2008, 26: 171-183. PMID: 19083088, PMCID: PMC2951284, DOI: 10.1007/s10827-008-0130-6.Peer-Reviewed Original Research
2003
In Vivo Modulation of Hippocampal Epileptiform Activity with Radial Electric Fields
Richardson K, Gluckman B, Weinstein S, Glosch C, Moon J, Gwinn R, Gale K, Schiff S. In Vivo Modulation of Hippocampal Epileptiform Activity with Radial Electric Fields. Epilepsia 2003, 44: 768-777. PMID: 12790889, DOI: 10.1046/j.1528-1157.2003.35402.x.Peer-Reviewed Original ResearchMeSH KeywordsAmplifiers, ElectronicAnimalsDisease Models, AnimalElectric StimulationElectric Stimulation TherapyElectrodes, ImplantedElectronics, MedicalEpilepsyHippocampusHumansKainic AcidKindling, NeurologicMaleMembrane PotentialsMicroelectrodesRatsRats, Sprague-DawleySeizuresStereotaxic TechniquesConceptsElectric field modulationRadial electric fieldElectric fieldElectric field controlField modulationMicroelectrode pairsCharge deliveryControl systemElectrode geometryField controlSeizure onset detectionElectrodeElectric field stimulationElectronicsStimulation electrodesFieldFirst resultsNovel approachExperiments
2002
Decreased Neuronal Synchronization during Experimental Seizures
Netoff T, Schiff S. Decreased Neuronal Synchronization during Experimental Seizures. Journal Of Neuroscience 2002, 22: 7297-7307. PMID: 12177225, PMCID: PMC6757884, DOI: 10.1523/jneurosci.22-16-07297.2002.Peer-Reviewed Original Research
2001
Adaptive Electric Field Control of Epileptic Seizures
Gluckman B, Nguyen H, Weinstein S, Schiff S. Adaptive Electric Field Control of Epileptic Seizures. Journal Of Neuroscience 2001, 21: 590-600. PMID: 11160438, PMCID: PMC6763796, DOI: 10.1523/jneurosci.21-02-00590.2001.Peer-Reviewed Original Research
1996
Electric field suppression of epileptiform activity in hippocampal slices
Gluckman B, Neel E, Netoff T, Ditto W, Spano M, Schiff S. Electric field suppression of epileptiform activity in hippocampal slices. Journal Of Neurophysiology 1996, 76: 4202-4205. PMID: 8985916, DOI: 10.1152/jn.1996.76.6.4202.Peer-Reviewed Original Research
1985
The effects of temperature on synaptic transmission in hippocampal tissue slices
Schiff S, Somjen G. The effects of temperature on synaptic transmission in hippocampal tissue slices. Brain Research 1985, 345: 279-284. PMID: 2994845, DOI: 10.1016/0006-8993(85)91004-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFemaleHippocampusIn Vitro TechniquesMembrane PotentialsRatsRats, Inbred StrainsSynapsesSynaptic TransmissionTemperatureHyperexcitability following moderate hypoxia in hippocampal tissue slices
Schiff S, Somjen G. Hyperexcitability following moderate hypoxia in hippocampal tissue slices. Brain Research 1985, 337: 337-340. PMID: 2992681, DOI: 10.1016/0006-8993(85)90071-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Membrane PermeabilityHippocampusHypoxia, BrainIn Vitro TechniquesMembrane PotentialsPotassiumRatsSodiumSynapsesSynaptic Transmission