Intranasal immunization with recombinant vesicular stomatitis virus expressing murine cytomegalovirus glycoprotein B induces humoral and cellular immunity.
Wilson SR, Wilson JH, Buonocore L, Palin A, Rose JK, Reuter JD. Intranasal immunization with recombinant vesicular stomatitis virus expressing murine cytomegalovirus glycoprotein B induces humoral and cellular immunity. Comparative Medicine 2008, 58: 129-39. PMID: 18524170, PMCID: PMC2703170.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntranasalAnimalsAntibody FormationCD8-Positive T-LymphocytesDNA, RecombinantDNA, ViralFemaleHerpesviridae InfectionsImmunity, CellularImmunizationInterferon-gammaMaleMiceMice, Inbred C57BLMuromegalovirusNeutralization TestsSpecific Pathogen-Free OrganismsSpleenVesiculovirusViral Envelope ProteinsViral VaccinesConceptsRecombinant vesicular stomatitis virusMurine cytomegalovirusIntranasal immunizationCellular immunityVesicular stomatitis virusSingle intranasal vaccinationStomatitis virusValuable animal modelIntranasal vaccinationMucosal vaccinationImmunized miceVaccine strategiesIFNgamma responsesVaccine prophylaxisCell surface expressionLeading causeImmune responseMouse modelVaccine vectorLive virusAnimal modelsViral infectionStrong cytoplasmicMajor envelope proteinSurface expression