The Beta-1 Adrenergic Antagonist, Betaxolol, Improves Working Memory Performance in Rats and Monkeys
Ramos BP, Colgan L, Nou E, Ovadia S, Wilson SR, Arnsten AF. The Beta-1 Adrenergic Antagonist, Betaxolol, Improves Working Memory Performance in Rats and Monkeys. Biological Psychiatry 2005, 58: 894-900. PMID: 16043136, DOI: 10.1016/j.biopsych.2005.05.022.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-1 Receptor AntagonistsAdrenergic beta-AntagonistsAnimalsAttentionBetaxololCognitionDose-Response Relationship, DrugHypnotics and SedativesMacaca mulattaMaleMaze LearningMemory, Short-TermMicroinjectionsPancreatic DiseasesPrefrontal CortexPsychomotor PerformanceRatsStereotaxic TechniquesConceptsMemory performancePrefrontal cortexPost-traumatic stress disorderPFC cognitive functionCognitive functioningStress disorderAlternation testingCognitive functionPFC functionBeta-1 adrenergic antagonistBeta 2 receptorsPFC dysfunctionPancreatic side effectsPFC infusionAged monkeysNoradrenergic activityCurrent studySelective beta 1 antagonistDose-related improvementBeta 1Beta 1/betaBeta-adrenergic receptor stimulationBeta-1 antagonistAdrenergic receptor stimulationWarrants further investigation