2024
Diagnostic Yield and Clinical Utility of Coronary Angiography Versus Coronary Function Testing in Women With Angina and Nonobstructive Coronary Arteries.
Cigarroa N, Latif N, Maayah M, Khokhar A, Kunnirickal S, Schwann A, Maciejewski K, Odanovic N, Mazure C, Spatz E, Pfau S, Lansky A, Shah S. Diagnostic Yield and Clinical Utility of Coronary Angiography Versus Coronary Function Testing in Women With Angina and Nonobstructive Coronary Arteries. Journal Of The American Heart Association 2024, 13: e035852. PMID: 39291500, DOI: 10.1161/jaha.124.035852.Peer-Reviewed Original ResearchCoronary function testingNonobstructive coronary arteriesInvasive coronary angiographyCoronary microvascular dysfunctionCoronary angiographyVasomotor disordersFunction testsCoronary arteryAntianginal therapyDiagnostic yieldVasospastic anginaMicrovascular dysfunctionDiagnostic yield of invasive coronary angiographyNonobstructive coronary artery diseaseSuspected ischemic heart diseaseCalcium channel blockersCoronary vasomotor disordersSymptomatic myocardial bridgingCoronary artery diseaseIschemic heart diseaseChannel blockersAnatomic diagnosisEndothelial dysfunctionArtery diseaseMyocardial bridgingReal-World Experience and Outcomes With Percutaneous Coronary Intervention for Protected Versus Unprotected Left Main Coronary Artery Disease: Insights from the Veteran Affairs Clinical Assessment Reporting and Tracking Program
Gonzalez P, Hebbe A, Hussain Y, Khera R, Banerjee S, Plomondon M, Waldo S, Pfau S, Curtis J, Shah S. Real-World Experience and Outcomes With Percutaneous Coronary Intervention for Protected Versus Unprotected Left Main Coronary Artery Disease: Insights from the Veteran Affairs Clinical Assessment Reporting and Tracking Program. The American Journal Of Cardiology 2024, 222: 39-50. PMID: 38677666, DOI: 10.1016/j.amjcard.2024.04.039.Peer-Reviewed Original ResearchULM percutaneous coronary interventionPercutaneous coronary interventionPropensity-matched cohortMyocardial infarctionCoronary interventionAll-cause mortalityTracking programUS clinical practiceOne-year MACEOne-year outcomesIncidence of rehospitalizationAdverse cardiovascular eventsUnprotected left main coronary artery diseaseAcute coronary syndromeCoronary artery diseaseRates of MIMechanical circulatory supportLeft main percutaneous coronary interventionPCI patientsUrgent revascularizationPractice patternsCart programLeft main bifurcationPrimary outcomeMatched cohort
2023
Use of telemedicine facilitated by trained telepresenters to manage advanced peripheral artery disease in rural areas
Breen T, Peake J, Keefe H, Moran J, Kunjukutty F, Pfau S, Altin S. Use of telemedicine facilitated by trained telepresenters to manage advanced peripheral artery disease in rural areas. Vascular Medicine 2023, 28: 239-240. PMID: 36628596, DOI: 10.1177/1358863x221148797.Peer-Reviewed Original Research
2022
Use of a Novel Catheter, the MOT-C, for Selective Angiography of the Internal Mammary Artery From Ipsilateral Radial Access.
Kunnirickal S, Pfau S, Moran E, Shah S. Use of a Novel Catheter, the MOT-C, for Selective Angiography of the Internal Mammary Artery From Ipsilateral Radial Access. Journal Of Invasive Cardiology 2022, 34: e408-e411. PMID: 35394451, DOI: 10.25270/jic/21.00233.Peer-Reviewed Original ResearchConceptsBypass angiographyInternal mammary arteryContrast volumeFemoral accessRadial accessMammary arteryNovel catheterIpsilateral radial accessLower contrast useCatheter-related complicationsSignificant differencesIMA graftsArtery catheterDiagnostic angiographySelective angiographyDiagnostic angiogramContrast useAngiographyCatheterArteryMinimal manipulationChest pain and coronary endothelial dysfunction after recovery from COVID‐19: A case series
Shah SM, Odanovic N, Kunnirickal S, Feher A, Pfau SE, Spatz ES. Chest pain and coronary endothelial dysfunction after recovery from COVID‐19: A case series. Clinical Case Reports 2022, 10: e05612. PMID: 35425611, PMCID: PMC8991764, DOI: 10.1002/ccr3.5612.Peer-Reviewed Case Reports and Technical NotesImplementation of supervised exercise therapy in a veteran population with symptomatic claudication
Altin S, Schneider MD, Parise H, Banerjee S, Wu WC, Meadows JL, Pfau S, Keefe H, Armstrong EJ. Implementation of supervised exercise therapy in a veteran population with symptomatic claudication. Vascular Medicine 2022, 27: 136-141. PMID: 35225695, DOI: 10.1177/1358863x211073622.Peer-Reviewed Original ResearchConceptsExercise treadmill testingExercise therapyMetabolic equivalentsIntermittent claudicationExercise capacityTreadmill testingAnkle-brachial indexIntermittent claudication symptomsMale veteran patientsSupervised exercise therapySymptomatic intermittent claudicationVascular specialty clinicsLow patient adherenceClaudication symptomsSymptomatic claudicationExercise groupVeteran patientsPatient adherenceRisk stratificationTherapy referralSpecialty clinicProvider awarenessVeteran populationClaudicationTherapy
2021
FEASIBILITY OF TELEMEDICINE IN THE EVALUATION OF CHRONIC LIMB THREATENING ISCHEMIA IN VETERANS
Altin S, Pfau S, Dominguez Y, Kunjukutty F, Keefe H. FEASIBILITY OF TELEMEDICINE IN THE EVALUATION OF CHRONIC LIMB THREATENING ISCHEMIA IN VETERANS. Journal Of The American College Of Cardiology 2021, 77: 1849. DOI: 10.1016/s0735-1097(21)03205-8.Peer-Reviewed Original Research
2020
The Foundational Role of Cardiovascular Imaging in the Characterization of Mental Stress–Induced Myocardial Ischemia in Patients with Coronary Artery Disease
Meadows JL, Shah S, Burg MM, Pfau S, Soufer R. The Foundational Role of Cardiovascular Imaging in the Characterization of Mental Stress–Induced Myocardial Ischemia in Patients with Coronary Artery Disease. Current Cardiology Reports 2020, 22: 162. PMID: 33037938, DOI: 10.1007/s11886-020-01407-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCoronary artery diseaseArtery diseaseMyocardial ischemiaMental Stress–Induced Myocardial IschemiaNon-obstructive coronary artery diseaseStable coronary artery diseaseHalf of patientsEpicardial coronary stenosisMental stress testingMyocardial oxygen demandUnderstanding of pathophysiologyCoronary macroAnginal symptomsCardiac eventsAdverse prognosisEarly mortalityIschemic phenomenaCoronary perfusionCoronary stenosisCoronary microvasculatureInvasive studiesClinical careMyocardial perfusionStress-mediated changesCardiac responseEffects of Psychological Stress on Vascular Physiology: Beyond the Current Imaging Signal
Shah SM, Meadows JL, Burg MM, Pfau S, Soufer R. Effects of Psychological Stress on Vascular Physiology: Beyond the Current Imaging Signal. Current Cardiology Reports 2020, 22: 156. PMID: 33037500, DOI: 10.1007/s11886-020-01406-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPsychological stressCardiovascular diseaseMental stress-induced myocardial ischemiaStress-induced myocardial ischemiaMental stressVascular smooth muscleMental stress effectsVascular systemCardiovascular imaging modalitiesEntire vascular systemCardiovascular manifestationsVascular effectsMicrovascular resistanceMicrovascular responsesVascular changesVascular mechanismsVascular responsesCardiovascular responsesMyocardial ischemiaLong-term consequencesSmooth muscleMicrovascular compartmentTherapeutic interventionsReviewThis reviewStandardized psychological assessmentsCardiovascular Imaging of Biology and Emotion
Meadows JL, Shah S, Burg MM, Pfau S, Soufer R. Cardiovascular Imaging of Biology and Emotion. Circulation Cardiovascular Imaging 2020, 13: e011054. PMID: 32762255, PMCID: PMC9261020, DOI: 10.1161/circimaging.120.011054.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMental stressEpicardial coronary artery diseaseCoronary artery diseaseExercise-induced changesMicrovascular dysfunctionArtery diseaseObstructive diseaseClinical manifestationsVascular responsesCentral activationCardiovascular healthPathophysiologic changesCardiovascular responsesMyocardial ischemiaPeripheral vasculatureTreatment targetsVascular pathophysiologyPsychosocial determinantsCardiovascular imagingPsychosocial experiencesImplementation studyMS testingTriggers activationCardiovascular biologyDiseaseEndotheliitis and Endothelial Dysfunction in Patients with COVID-19: Its Role in Thrombosis and Adverse Outcomes †
Mosleh W, Chen K, Pfau SE, Vashist A. Endotheliitis and Endothelial Dysfunction in Patients with COVID-19: Its Role in Thrombosis and Adverse Outcomes †. Journal Of Clinical Medicine 2020, 9: 1862. PMID: 32549229, PMCID: PMC7356402, DOI: 10.3390/jcm9061862.Peer-Reviewed Original ResearchSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Syndrome coronavirus 2Coronavirus disease 2019Cardiovascular manifestationsEndothelial dysfunctionAdverse outcomesCoronavirus 2Disease 2019COVID-19Contagious diseaseEndotheliitisThrombosisPatientsDysfunctionDisease
2019
Coronary Physiology in the Cardiac Catheterization Laboratory
Shah SM, Pfau SE. Coronary Physiology in the Cardiac Catheterization Laboratory. Journal Of Clinical Medicine 2019, 8: 255. PMID: 30781631, PMCID: PMC6406799, DOI: 10.3390/jcm8020255.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCoronary artery diseaseCoronary flow velocity reserveCoronary flow reserveInstantaneous wave-free ratioCardiac catheterization laboratoryFractional flow reserveArtery diseaseCatheterization laboratoryCoronary angiographyClinical trialsFlow reserveCoronary physiologyEpicardial coronary artery diseaseEvidence-based treatment algorithmAtherosclerotic coronary artery diseaseLarge multi-center clinical trialsAngiographic coronary stenosisCoronary physiology assessmentMulti-center clinical trialDiagnostic coronary angiographyFlow velocity reserveRelevant clinical trialsCoronary artery assessmentGeneral medical practitionersCoronary thermodilution
2018
Heart Failure After Ischemic Stroke or Transient Ischemic Attack in Insulin-Resistant Patients Without Diabetes Mellitus Treated With Pioglitazone
Young LH, Viscoli CM, Schwartz GG, Inzucchi SE, Curtis JP, Gorman MJ, Furie KL, Conwit R, Spatz E, Lovejoy A, Abbott JD, Jacoby DL, Kolansky DM, Ling FS, Pfau SE, Kernan WN. Heart Failure After Ischemic Stroke or Transient Ischemic Attack in Insulin-Resistant Patients Without Diabetes Mellitus Treated With Pioglitazone. Circulation 2018, 138: 1210-1220. PMID: 29934374, PMCID: PMC6202153, DOI: 10.1161/circulationaha.118.034763.Peer-Reviewed Original ResearchConceptsRisk of HFTransient ischemic attackEffect of pioglitazoneHF riskHeart failureInsulin-resistant patientsMyocardial infarctionIschemic attackCardiovascular benefitsIschemic strokeDiabetes mellitusInsulin resistanceHigher C-reactive proteinComposite of strokeHF risk scoreHigher HF riskDrug dose reductionHospitalized heart failureIncident myocardial infarctionLower mean doseC-reactive proteinBaseline patient featuresHF hospitalizationCardiovascular eventsPlacebo groupPercutaneous Left Main Coronary Intervention: A Review of Plaque Modification in Left Main Percutaneous Coronary Intervention
Shah CA, Pfau SE. Percutaneous Left Main Coronary Intervention: A Review of Plaque Modification in Left Main Percutaneous Coronary Intervention. Journal Of Clinical Medicine 2018, 7: 180. PMID: 30041422, PMCID: PMC6068647, DOI: 10.3390/jcm7070180.Peer-Reviewed Original ResearchPercutaneous coronary interventionMain percutaneous coronary interventionCoronary interventionDrug eluting stentsPlaque volumeIntravascular ultrasoundLeft main percutaneous coronary interventionMain coronary artery stenosisLMCA bifurcation lesionsMain Coronary InterventionCoronary bypass surgeryCurrent treatment algorithmsCoronary artery stenosisIndividual patient characteristicsMinimal stent areaLMCA lesionsLMCA stenosisBypass surgeryPatient characteristicsPlaque modificationArtery stenosisDES eraTreatment algorithmCoronary segmentsBifurcation lesionsMultimodality Imaging Involving Magnetic Resonance Facilitates Giant Symptomatic Myxoma Resection
Hur DJ, Prescher LM, Meadows JL, Pfau SE, Homer RJ, Tellides G, Yun JJ. Multimodality Imaging Involving Magnetic Resonance Facilitates Giant Symptomatic Myxoma Resection. The Annals Of Thoracic Surgery 2018, 107: e15-e17. PMID: 30558736, DOI: 10.1016/j.athoracsur.2018.05.083.Peer-Reviewed Case Reports and Technical Notes
2017
Cardiac Outcomes After Ischemic Stroke or Transient Ischemic Attack
Young LH, Viscoli CM, Curtis JP, Inzucchi SE, Schwartz GG, Lovejoy AM, Furie KL, Gorman MJ, Conwit R, Abbott JD, Jacoby DL, Kolansky DM, Pfau SE, Ling FS, Kernan WN. Cardiac Outcomes After Ischemic Stroke or Transient Ischemic Attack. Circulation 2017, 135: 1882-1893. PMID: 28246237, PMCID: PMC5511545, DOI: 10.1161/circulationaha.116.024863.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeType 1 myocardial infarctionTransient ischemic attackMyocardial infarctionCoronary syndromeInsulin resistanceIschemic attackIschemic strokeDiabetes mellitusSerum troponinAcute coronary syndrome episodeMean age 63 yearsAcute coronary syndrome eventIndependent clinical events committeeType 2 myocardial infarctionIRIS participantsImpact of pioglitazoneRecent cerebrovascular eventsRecent ischemic strokeClinical events committeeAge 63 yearsEffect of pioglitazoneSmall myocardial infarctionCoronary artery diseaseST-segment elevation
2016
The Sweatshirt Sign: Coronary Artery Disease
Federman DG, Pfau SE. The Sweatshirt Sign: Coronary Artery Disease. The American Journal Of Medicine 2016, 129: 1267. PMID: 27568344, DOI: 10.1016/j.amjmed.2016.07.025.Peer-Reviewed Original Research
2015
AORTIC VALVE DISEASE IN ELDERLY: TRENDS OF HOSPITALIZATIONS IN US, 2000-2012
Badheka A, Singh V, Patel N, Arora S, Patel N, Thakkar B, Jhamnani S, Chothani A, Panaich S, Patel J, Deshmukh A, Manvar S, Mangi A, Pfau S, Cleman M, Forrest J. AORTIC VALVE DISEASE IN ELDERLY: TRENDS OF HOSPITALIZATIONS IN US, 2000-2012. Journal Of The American College Of Cardiology 2015, 65: a1951. DOI: 10.1016/s0735-1097(15)61951-9.Peer-Reviewed Original Research
2012
Cellularity and structure of fresh human coronary thrombectomy specimens; presence of cells with markers of progenitor cells
Jovin IS, Lei L, Huang Y, Hao Z, Curtis JP, Brennan JJ, Remetz MS, Setaro JF, Pfau SE, Howes CJ, Clancy JF, Cabin HS, Cleman MW, Giordano FJ. Cellularity and structure of fresh human coronary thrombectomy specimens; presence of cells with markers of progenitor cells. Journal Of Cellular And Molecular Medicine 2012, 16: 3022-3027. PMID: 22947374, PMCID: PMC4393730, DOI: 10.1111/j.1582-4934.2012.01629.x.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeCoronary thrombectomyCoronary syndromeProgenitor cellsCholesterol crystalsAcute myocardial infarctionEndothelial progenitor cellsFormation of thrombiHaematopoietic progenitor cellsVon Willebrand factorInflammatory cellsEndothelial cell mediumMyocardial infarctionPlaque ruptureThrombectomyImmunohistochemical analysisVascular wallPresence of cellsBlood cellsWillebrand factorThrombusRecovery of left ventricular function after percutaneous revascularization of a left main chronic total occlusion
Khanna P, Stilp E, Pfau S. Recovery of left ventricular function after percutaneous revascularization of a left main chronic total occlusion. Catheterization And Cardiovascular Interventions 2012, 80: 310-315. PMID: 22553190, DOI: 10.1002/ccd.24322.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiomyopathy, DilatedChronic DiseaseCoronary AngiographyCoronary OcclusionDrug-Eluting StentsHumansMaleMyocardial Perfusion ImagingPercutaneous Coronary InterventionPositron-Emission TomographyRecovery of FunctionStroke VolumeTreatment OutcomeVentricular Dysfunction, LeftVentricular Function, LeftConceptsLeft ventricular ejection fractionPercutaneous coronary interventionCoronary artery diseaseMain percutaneous coronary interventionChronic total occlusionSurgical revascularizationTotal occlusionThree-vessel coronary artery diseaseDepressed left ventricular ejection fractionMultivessel coronary artery diseaseMultivessel percutaneous coronary interventionIntermediate-term mortalityLeft ventricular dysfunctionVentricular ejection fractionLeft ventricular functionLeft ventricular sizeComplete revascularizationPercutaneous revascularizationTerm mortalityVentricular dysfunctionCoronary interventionArtery diseaseEjection fractionImproved survivalMedical therapy