2011
High Resolution X-Ray Structure of Snake Venom Factor V: Evolution of a Hemostatic Cofactor to a Toxin Poised to Inflict Maximal Damage to Mammalian Blood Coagulation
Kumar S, Stayrook S, Huntington J, Camire R, Krishnaswamy S. High Resolution X-Ray Structure of Snake Venom Factor V: Evolution of a Hemostatic Cofactor to a Toxin Poised to Inflict Maximal Damage to Mammalian Blood Coagulation. Blood 2011, 118: 375. DOI: 10.1182/blood.v118.21.375.375.Peer-Reviewed Original ResearchC2 domainA2 domainVenom proteinsB domainVenom of Pseudonaja textilisMembrane-dependent reactionsA1-A2-B-A3-C1-C2Absence of membranesMammalian coagulationSequence alignmentMammalian blood coagulationDomain organizationMolecular replacementRegulating blood coagulationToxin repertoireProtruding loopBinding to membranesHydrophobic residuesProteolytic processingBind membranesResolution structureMembrane bindingA-resolutionActivation of human prothrombinProteolytic activity
2007
Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators
Yaklichkin S, Vekker A, Stayrook S, Lewis M, Kessler D. Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators. BMC Genomics 2007, 8: 201. PMID: 17598915, PMCID: PMC1939712, DOI: 10.1186/1471-2164-8-201.Peer-Reviewed Original ResearchConceptsEh1-like motifsFox gene familyFox family proteinsFox proteinsGroucho interaction motifEh1 motifGene familyTranscriptional regulationFOX familyFamily proteinsInteraction motifsStructure predictionWinged helix DNA-binding domainFamily of transcriptional regulatorsSecondary structure predictionDNA-binding domainN-terminal motifSwiss protein databaseManual sequence alignmentFOX family genesDivergent speciesSequence alignmentProtein sequencesProtein databaseTranscriptional corepressor