Rational design of photosynthetic reaction center protein maquettes
Ennist N, Stayrook S, Dutton P, Moser C. Rational design of photosynthetic reaction center protein maquettes. Frontiers In Molecular Biosciences 2022, 9: 997295. PMID: 36213121, PMCID: PMC9532970, DOI: 10.3389/fmolb.2022.997295.Peer-Reviewed Original ResearchNatural photosystemsCrystal structureSolar-to-fuel energy conversionAssemble metal ionsElectron-transfer reactionsPhotosynthetic charge separationPhotosynthetic reaction centersCharge separationElectron tunneling theoryChemical fuelsMetal ionsReaction centerElectron donorHolo-stateStructural transitionEnergy conversionElectron acceptorModular strategySpectroscopic assaysReactionPhoton energyCrystalState of assemblyProtein designProduction of biofuelsDe novo protein design of photochemical reaction centers
Ennist N, Zhao Z, Stayrook S, Discher B, Dutton P, Moser C. De novo protein design of photochemical reaction centers. Nature Communications 2022, 13: 4937. PMID: 35999239, PMCID: PMC9399245, DOI: 10.1038/s41467-022-32710-5.Peer-Reviewed Original ResearchConceptsCharge separationSolar-to-fuel energy conversionReaction centerLight-driven charge separationX-ray crystal structurePhotosynthetic reaction center proteinCharge separation lifetimeSolar fuel productionTransient absorption spectroscopyPhotosynthetic reaction centersPhotochemical charge separationModify natural proteinsPhotochemical reaction centerReaction center proteinCluster oxidationRedox centersCrystal structureAbsorption spectroscopyElectron transfer activityNatural protein structuresDe novo protein designPhotosynthetic protein complexesEnergy conversionX-rayProtein framework