2024
Molecular Imaging of Fibroblast Activation in Lower Extremity Skeletal Muscles Using a 99mTc-Labeled Inhibitor of Fibroblast Activation Protein in Porcine Model of Peripheral Artery Disease
Jang S, Thorn S, Zohora F, Porcaro O, Burns R, Vermillion B, Callegari S, Guerrera N, DePino A, Liu C, Luna-Gutierrez M, Ferro-Flores G, Sinusas A. Molecular Imaging of Fibroblast Activation in Lower Extremity Skeletal Muscles Using a 99mTc-Labeled Inhibitor of Fibroblast Activation Protein in Porcine Model of Peripheral Artery Disease. Journal Of Nuclear Cardiology 2024, 38: 101997. DOI: 10.1016/j.nuclcard.2024.101997.Peer-Reviewed Original ResearchHybrid SPECT/CT Imaging of Fibroblast Activation Protein Post Myocardial Infarction on Novel 360° CZT Scanner
Thorn S, Burns R, Zohora F, Jang S, Porcaro O, Guerrera N, DePino A, Vermillion B, Liu C, Luna-Gutiérrez M, Ferro-Flores G, Sinusas A. Hybrid SPECT/CT Imaging of Fibroblast Activation Protein Post Myocardial Infarction on Novel 360° CZT Scanner. Journal Of Nuclear Cardiology 2024, 38: 101972. DOI: 10.1016/j.nuclcard.2024.101972.Peer-Reviewed Original ResearchNon-invasive Estimation Of Right Ventricle-Pulmonary Artery Coupling Using Multiphase Cardiac Computed Tomography Angiography In Pig Model Of Acute Respiratory Distress Syndrome
Jang S, Thorn S, Vermillion B, Alashi A, Zohora F, Lee S, Ahn S, Burns R, Dela Cruz C, Zeiss C, Spinale F, Heerdt P, Sinusas A. Non-invasive Estimation Of Right Ventricle-Pulmonary Artery Coupling Using Multiphase Cardiac Computed Tomography Angiography In Pig Model Of Acute Respiratory Distress Syndrome. Journal Of Cardiovascular Computed Tomography 2024, 18: s46. DOI: 10.1016/j.jcct.2024.05.106.Peer-Reviewed Original ResearchEarly Transient CT Enhancement Post Myocardial Infarction Is Associated With Technetium-99m Pyrophosphate Uptake And Calcium Deposition
Zohora F, Lee S, Lin A, Jang S, Vermillion B, Burns R, Callegari S, DePino A, Guerrera N, Thorn S, Sinusas A. Early Transient CT Enhancement Post Myocardial Infarction Is Associated With Technetium-99m Pyrophosphate Uptake And Calcium Deposition. Journal Of Cardiovascular Computed Tomography 2024, 18: s25-s26. DOI: 10.1016/j.jcct.2024.05.058.Peer-Reviewed Original ResearchDevelopment Of Ct Quantitative Tools To Assess Collateral Formation In Rabbit Model Of Hind Limb Ischemia: Implications For Evaluation Of Vascular Reserve.
Vermillion B, Jang S, Alashi A, Burns R, Guerrera N, Depino A, Martins S, Papademetris X, Zeiss C, Guo L, Liu C, Thorn S, Sinusas A. Development Of Ct Quantitative Tools To Assess Collateral Formation In Rabbit Model Of Hind Limb Ischemia: Implications For Evaluation Of Vascular Reserve. Journal Of Cardiovascular Computed Tomography 2024, 18: s50-s51. DOI: 10.1016/j.jcct.2024.05.117.Peer-Reviewed Original ResearchCoordinate-Independent 3-D Ultrasound Principal Stretch and Direction Imaging
Jeng G, Chen P, Hsieh M, Liu Z, Langdon J, Ahn S, Staib L, Stendahl J, Thorn S, Sinusas A, Duncan J, O'Donnell M. Coordinate-Independent 3-D Ultrasound Principal Stretch and Direction Imaging. IEEE Transactions On Biomedical Engineering 2024, PP: 1-12. PMID: 38941195, DOI: 10.1109/tbme.2024.3420220.Peer-Reviewed Original ResearchPrincipal stretchesAxial displacement componentsSpeckle tracking methodSpeckle tracking approachTracking methodRobust filterDisplacement componentsTissue incompressibilityDisplacement estimationStrain componentsDisplacement gradientsStrain informationLocalized diseased regionStrain imagingLagrangian strainLeast-squares methodTracking approachTracking frameworkCoordinate systemCardiac coordinate systemProbe orientationFilterHigher spatial resolutionCardiac datasetsEnhanced accuracyComparative study of functional and structural muscle changes in peripheral artery disease: rubidium-82 positron emission tomography and histological correlation
Alashi A, Vermillion B, Callegari S, Burns R, Guo L, Moulton E, Guerrera N, Depino A, Papademetris X, Zeiss C, Thorn S, Liu C, Sinusas A. Comparative study of functional and structural muscle changes in peripheral artery disease: rubidium-82 positron emission tomography and histological correlation. European Heart Journal - Cardiovascular Imaging 2024, 25: jeae142.087. DOI: 10.1093/ehjci/jeae142.087.Peer-Reviewed Original ResearchPeripheral arterial diseaseStandardized uptake valueHindlimb ischemia modelReactive hyperemiaSkeletal muscle perfusionPerfusion reserveCapillary densityPET imagingArtery diseaseNon-ischemicRubidium-82 positron emission tomographyType 2 muscle fibersRelevant pre-clinical modelIndicative of fibrosisManagement of peripheral arterial diseaseCapillary to muscle fiber ratioClinically relevant pre-clinical modelPre-clinical modelsMuscle perfusionFast myosinWeeks post-ligationRb-82 uptakeEvaluate treatment strategiesRabbit hindlimb ischemia modelPositron emission tomographyLinks Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes
Aneni E, Sinusas A, Emokpae M, Thorn S, Yaggi H, Miller E. Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes. Current Cardiology Reports 2024, 26: 723-734. PMID: 38806976, DOI: 10.1007/s11886-024-02072-z.Peer-Reviewed Original ResearchObstructive sleep apneaCoronary microvascular dysfunctionAbnormal myocardial blood flowSevere obstructive sleep apneaMyocardial flow reserveMyocardial blood flowSleep apneaModerate to severe obstructive sleep apneaAbnormal myocardial flow reserveRecent FindingsRecent studiesDisease-related outcomesBlood flow changesMyocardial blood flow changesCardiovascular disease-related outcomesMicrovascular dysfunctionClinical impactCPAPReviewRecent studiesStructural abnormalitiesCoronary microcirculationFindingsRecent studiesFlow reserveCardiac workBlood flowApneaMulti-Task Learning for Motion Analysis and Segmentation in 3D Echocardiography
Ta K, Ahn S, Thorn S, Stendahl J, Zhang X, Langdon J, Staib L, Sinusas A, Duncan J. Multi-Task Learning for Motion Analysis and Segmentation in 3D Echocardiography. IEEE Transactions On Medical Imaging 2024, 43: 2010-2020. PMID: 38231820, DOI: 10.1109/tmi.2024.3355383.Peer-Reviewed Original ResearchMulti-task learning networkCross-stitch unitsComposite loss functionAccurate motion estimationTask-specific networksMotion estimationSegmentation masksLearning networkLoss functionSegmentation stepEchocardiography datasetNetworkMotion displacementMotion analysisMultiple time framesTaskAnalysis pipelineSegmentsStrain measurementsDatasetRepresentationMULTIMODALITY IMAGING GUIDED INTRAMYOCARDIAL DELIVERY OF IMAGEABLE HYDROGEL POST MYOCARDIAL INFARCTION IMPROVES STRAIN ASSOCIATED WITH INTEGRIN ACTIVATION
Melvinsdottir I, Midgett D, Lee S, Chen K, Avendano R, Ahn S, Thorn S, Uman S, Sinusas A. MULTIMODALITY IMAGING GUIDED INTRAMYOCARDIAL DELIVERY OF IMAGEABLE HYDROGEL POST MYOCARDIAL INFARCTION IMPROVES STRAIN ASSOCIATED WITH INTEGRIN ACTIVATION. Journal Of The American College Of Cardiology 2024, 83: 1399. DOI: 10.1016/s0735-1097(24)03389-8.Peer-Reviewed Original ResearchASSESSING VASCULAR FLOW IN ACUTE AND CHRONIC RABBIT MODELS OF HINDLIMB ISCHEMIA USING HIGH-RESOLUTION 2D ANGIOGRAPHY: IMPLICATIONS FOR PET FLOW QUANTIFICATION
Callegari S, Vermillion B, Alashi A, Burns R, Jang S, Guerrera N, Guo L, Depino A, Zohora F, Smolderen K, Hurtado C, Liu C, Thorn S, Sinusas A. ASSESSING VASCULAR FLOW IN ACUTE AND CHRONIC RABBIT MODELS OF HINDLIMB ISCHEMIA USING HIGH-RESOLUTION 2D ANGIOGRAPHY: IMPLICATIONS FOR PET FLOW QUANTIFICATION. Journal Of The American College Of Cardiology 2024, 83: 2251. DOI: 10.1016/s0735-1097(24)04241-4.Peer-Reviewed Original Research
2023
The development of a novel endovascular grasper for challenging inferior vena cava filter retrieval
Ochoa Chaar C, Kostiuk V, Rodriguez P, Kim T, Rathbone D, Ghandour L, Burns R, Thorn S, Sinusas A, Guzman R, Dardik A. The development of a novel endovascular grasper for challenging inferior vena cava filter retrieval. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2023, 12: 101731. PMID: 38081514, DOI: 10.1016/j.jvsv.2023.101731.Peer-Reviewed Original ResearchImprovement in cardiac function and regional LV strain following intramyocardial injection of a theranostic hydrogel early postmyocardial infarction in a porcine model
Avendaño R, Midgett D, Melvinsdottir I, Thorn S, Uman S, Pickell Z, Lee S, Liu Z, Mamarian M, Duncan J, Spinale F, Burdick J, Sinusas A. Improvement in cardiac function and regional LV strain following intramyocardial injection of a theranostic hydrogel early postmyocardial infarction in a porcine model. Journal Of Applied Physiology 2023, 135: 405-420. PMID: 37318987, PMCID: PMC10538987, DOI: 10.1152/japplphysiol.00342.2022.Peer-Reviewed Original ResearchConceptsMyocardial infarctionIntramyocardial deliveryLV hemodynamicsControl groupFunctional indexEarly post-myocardial infarctionSystolic functional indicesMyocardial performance indexAnterolateral myocardial infarctionLeft anterior descendingPressure-volume loop areaLeft ventricular remodelingGlobal LV functionLV functional changesPost-myocardial infarctionSupply/demand ratioRegional LV strainHydrogel groupTei indexEjection fractionHeart failureAnterior descendingCircumflex arteryLV functionAortic pressureComprehensive Multimodality Imaging of Congenitally Corrected Transposition of the Great Arteries Incidentally Found to Have Coronary Ischemia
Sasse A, Feher A, Thorn S, Fahey J, Keeshan B, Sinusas A, Mojibian H, Steele J. Comprehensive Multimodality Imaging of Congenitally Corrected Transposition of the Great Arteries Incidentally Found to Have Coronary Ischemia. Circulation Cardiovascular Imaging 2023, 16: 597-600. PMID: 37092334, DOI: 10.1161/circimaging.122.015158.Peer-Reviewed Case Reports and Technical NotesThe Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow Reserve
Aneni E, Thorn S, Feher A, Hong Chen J, Sinusas A, Yaggi H, Miller E. The Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow Reserve. JACC Cardiovascular Imaging 2023, 16: 856-858. PMID: 36881426, PMCID: PMC10718199, DOI: 10.1016/j.jcmg.2022.11.024.Peer-Reviewed Original Research
2022
Co-attention spatial transformer network for unsupervised motion tracking and cardiac strain analysis in 3D echocardiography
Ahn S, Ta K, Thorn S, Onofrey J, Melvinsdottir I, Lee S, Langdon J, Sinusas A, Duncan J. Co-attention spatial transformer network for unsupervised motion tracking and cardiac strain analysis in 3D echocardiography. Medical Image Analysis 2022, 84: 102711. PMID: 36525845, PMCID: PMC9812938, DOI: 10.1016/j.media.2022.102711.Peer-Reviewed Original ResearchConceptsSpatial transformer networkMotion trackingNoisy displacement fieldReliable motion estimationMotion tracking methodCardiac strain analysisTransformer networkDisplacement fieldDisplacement pathsMotion fieldTracking methodMotion estimationExperimental resultsStrain analysisSuperior performanceTemporal constraintsCardiac motionTrackingRegularization functionDependent featuresEchocardiography imagesNetworkPrior assumptionsFieldQuantification of intramyocardial blood volume using 99mTc-RBC SPECT/CT: a pilot human study
Yousefi H, Shi L, Soufer A, Tsatkin V, Bruni W, Avendano R, Greco K, McMahon D, Thorn S, Miller E, Sinusas A, Liu C. Quantification of intramyocardial blood volume using 99mTc-RBC SPECT/CT: a pilot human study. Journal Of Nuclear Cardiology 2022, 30: 292-297. PMID: 36319815, DOI: 10.1007/s12350-022-03123-0.Peer-Reviewed Original ResearchCellular recovery after prolonged warm ischaemia of the whole body
Andrijevic D, Vrselja Z, Lysyy T, Zhang S, Skarica M, Spajic A, Dellal D, Thorn SL, Duckrow RB, Ma S, Duy PQ, Isiktas AU, Liang D, Li M, Kim SK, Daniele SG, Banu K, Perincheri S, Menon MC, Huttner A, Sheth KN, Gobeske KT, Tietjen GT, Zaveri HP, Latham SR, Sinusas AJ, Sestan N. Cellular recovery after prolonged warm ischaemia of the whole body. Nature 2022, 608: 405-412. PMID: 35922506, PMCID: PMC9518831, DOI: 10.1038/s41586-022-05016-1.Peer-Reviewed Original ResearchConceptsSingle-nucleus transcriptomic analysesSpecific gene expression patternsCellular recoveryGene expression patternsCellular processesMammalian cellsTranscriptomic analysisLarge mammalsExpression patternsCellular repair processesCell deathComprehensive resourceUnderappreciated potentialPhysiological challengesTissue integrityRepair processSpecific changesPorcine brainMammalsOrgansMultiple organsDeep-Learning-Based Few-Angle Cardiac SPECT Reconstruction Using Transformer
Xie H, Thorn S, Liu Y, Lee S, Liu Z, Wang G, Sinusas A, Liu C. Deep-Learning-Based Few-Angle Cardiac SPECT Reconstruction Using Transformer. IEEE Transactions On Radiation And Plasma Medical Sciences 2022, 7: 33-40. PMID: 37397179, PMCID: PMC10312390, DOI: 10.1109/trpms.2022.3187595.Peer-Reviewed Original ResearchConvolutional neural networkLimitations of CNNMedical imaging tasksDeep U-NetImage reconstruction taskCardiac SPECT imagesComputer visionVision TransformerConvolutional kernelsTransformer networkAttention blockInput imageU-NetNeural networkMemory burdenImage sizeInductive biasInformative featuresImage volumesImaging tasksTesting dataNetworkWhole 3D volumeNetwork structureCardiac single photon emissionMatrix Metalloproteinase-Targeted SPECT/CT Imaging for Evaluation of Therapeutic Hydrogels for the Early Modulation of Post-Infarct Myocardial Remodeling
Thorn SL, Shuman JA, Stacy MR, Purcell BP, Doviak H, Burdick JA, Spinale FG, Sinusas AJ. Matrix Metalloproteinase-Targeted SPECT/CT Imaging for Evaluation of Therapeutic Hydrogels for the Early Modulation of Post-Infarct Myocardial Remodeling. Journal Of Cardiovascular Translational Research 2022, 16: 155-165. PMID: 35697979, PMCID: PMC10836411, DOI: 10.1007/s12265-022-10280-7.Peer-Reviewed Original Research