2024
Beyond Earth’s bounds: navigating the frontiers of Assisted Reproductive Technologies (ART) in space
Chaplia O, Mathyk B, Nichols-Burns S, Basar M, Halicigil C. Beyond Earth’s bounds: navigating the frontiers of Assisted Reproductive Technologies (ART) in space. Reproductive Biology And Endocrinology 2024, 22: 123. PMID: 39394617, PMCID: PMC11468284, DOI: 10.1186/s12958-024-01290-y.Peer-Reviewed Original ResearchConceptsAssisted reproductive technologyIn vitro embryo developmentReproductive technologyRadiation-induced damageGamete handlingClinical embryologistsReproductive endocrinologistsTemperature limitEmbryo cultureReproductive medicineLow Earth orbitEmbryo developmentDeep space travelEarth orbitSpace environmentInterplanetary speciesEarth-boundMicrofluidic devicesCryopreservationSERUM ANTI-MULLERIAN HORMONE IS ASSOCIATED WITH PREOVULATORY FOLLICLE CUMULUS CELL MITOCHONDRIAL DNA COPY NUMBER
Volovsky M, Seifer D, Sahin G, Chaplia O, Nichols-Burns S, Basar M, Seli E, Halicigil C. SERUM ANTI-MULLERIAN HORMONE IS ASSOCIATED WITH PREOVULATORY FOLLICLE CUMULUS CELL MITOCHONDRIAL DNA COPY NUMBER. Fertility And Sterility 2024, 122: e199. DOI: 10.1016/j.fertnstert.2024.07.662.Peer-Reviewed Original ResearchEXAMINING RELEVANCE OF AGE AND BODY MASS INDEX FOR EMBRYO MORPHOKINETICS
Dzienny A, Wesevich V, Nichols-Burns S, Chaplia O, Basar M, Unsal E, Halicigil C, Pal L. EXAMINING RELEVANCE OF AGE AND BODY MASS INDEX FOR EMBRYO MORPHOKINETICS. Fertility And Sterility 2024, 122: e195. DOI: 10.1016/j.fertnstert.2024.07.652.Peer-Reviewed Original ResearchEVALUATING THE EFFECTIVENESS OF CONVENTIONAL IVF IN CASES WITH LOW OOCYTE YIELD AND ADVANCED MATERNAL AGE (AMA)
Nichols-Burns S, Chaplia O, Unsal E, Basar M, Halicigil C. EVALUATING THE EFFECTIVENESS OF CONVENTIONAL IVF IN CASES WITH LOW OOCYTE YIELD AND ADVANCED MATERNAL AGE (AMA). Fertility And Sterility 2024, 122: e287-e288. DOI: 10.1016/j.fertnstert.2024.07.891.Peer-Reviewed Original ResearchTHE IMPACT OF ENDOMETRIAL AND EMBRYO RELATED FACTORS ON CLINICAL OUTCOMES AND LIVE BIRTH IN PROGRAMMED AND MODIFIED NATURAL FET CYCLES WITH EUPLOID EMBRYO TRANSFERS
Halicigil C, Basar M, Chaplia O, Nichols-Burns S. THE IMPACT OF ENDOMETRIAL AND EMBRYO RELATED FACTORS ON CLINICAL OUTCOMES AND LIVE BIRTH IN PROGRAMMED AND MODIFIED NATURAL FET CYCLES WITH EUPLOID EMBRYO TRANSFERS. Fertility And Sterility 2024, 122: e65. DOI: 10.1016/j.fertnstert.2024.07.249.Peer-Reviewed Original Research
2022
FROM OOCYTES TO A LIVE BIRTH: DOES PGT-A HELP OR HARM?
Sabbagh R, S N, Halicigil C, Quinlan J, Shah J, Korkidakis A, Penzias A, Patrizio P, Sakkas D. FROM OOCYTES TO A LIVE BIRTH: DOES PGT-A HELP OR HARM? Fertility And Sterility 2022, 118: e10-e11. DOI: 10.1016/j.fertnstert.2022.09.232.Peer-Reviewed Original ResearchICSI IS ASSOCIATED WITH LOWER BLASTULATION RATES COMPARED TO CONVENTIONAL IVF AMONG COUPLES WITH NON-MALE FACTOR INFERTILITY AND LOW OOCYTE YIELD
Beroukhim G, Seifer D, Chaplia O, Nichols-Burns S, Basar M, Halicigil C. ICSI IS ASSOCIATED WITH LOWER BLASTULATION RATES COMPARED TO CONVENTIONAL IVF AMONG COUPLES WITH NON-MALE FACTOR INFERTILITY AND LOW OOCYTE YIELD. Fertility And Sterility 2022, 118: e143. DOI: 10.1016/j.fertnstert.2022.08.419.Peer-Reviewed Original Research
2021
Miscarriage determination in first trimester based on alpha-fetoprotein extracted from sanitary pads
Mor A, Gardezi M, Jubanyik K, Simsek B, Seifer DB, Patrizio P, Esencan E, Imamoglu G, Zhang M, Nichols-Burns SM, Taylor HS. Miscarriage determination in first trimester based on alpha-fetoprotein extracted from sanitary pads. Fertility And Sterility 2021, 116: 462-469. PMID: 33461753, DOI: 10.1016/j.fertnstert.2020.10.006.Peer-Reviewed Original ResearchConceptsExtrauterine pregnancyVaginal bloodAlpha-fetoproteinOngoing pregnancyAFP levelsSanitary padsHigh alpha-fetoprotein levelsOngoing pregnancy groupProspective cohort studyAlpha-fetoprotein levelsAcademic medical centerPregnancy groupCohort studyMiscarriage casesFirst trimesterOffice visitsMedical CenterMAIN OUTCOMEPregnancyMedian levelsMiscarriageBloodAnxiety levelsAFPCharacteristic analysis
2019
A step towards the automation of intracytoplasmic sperm injection: real time confirmation of mouse and human oocyte penetration and viability by electrical resistance measurement
Mor A, Zhang M, Esencan E, Simsek B, Nichols-Burns SM, Liu Y, Lo J, Kelk DA, Flores V, Gao XB, Seli E. A step towards the automation of intracytoplasmic sperm injection: real time confirmation of mouse and human oocyte penetration and viability by electrical resistance measurement. Fertility And Sterility 2019, 113: 234-236. PMID: 31883732, DOI: 10.1016/j.fertnstert.2019.09.023.Peer-Reviewed Original ResearchConceptsIntracytoplasmic sperm injectionICSI pipetteSperm injectionOocyte penetrationIntact oolemmaOocyte retrieval procedureMann-Whitney testMouse oocytesOocyte retrievalFemale miceMAIN OUTCOMEAcademic centersImmature oocytesHuman oocytesMature oocytesObjective toolMiceOocytesWomenVisual assessmentPipetteInjectionOolemmaStep 1GroupDay 2 laser assisted hatching (AH) significantly improves implantation rates in fresh blastocyst transfers
Bjorkman S, Nichols-Burns S, Lo J, Kodaman N, Kodaman P, Kelk D. Day 2 laser assisted hatching (AH) significantly improves implantation rates in fresh blastocyst transfers. Fertility And Sterility 2019, 112: e292. DOI: 10.1016/j.fertnstert.2019.07.856.Peer-Reviewed Original ResearchA step towards the automation of intracytoplasmic sperm injection (ICSI): real time confirmation of oocyte penetration by electrical resistance measurement
Mor A, Zhang M, Esencan E, Simsek B, Nichols-Burns S, Liu Y, Lo J, Kelk D, Gao X, Seli E. A step towards the automation of intracytoplasmic sperm injection (ICSI): real time confirmation of oocyte penetration by electrical resistance measurement. Fertility And Sterility 2019, 112: e90-e91. DOI: 10.1016/j.fertnstert.2019.07.357.Peer-Reviewed Original ResearchPrediction of pregnancy outcome in women with first trimester bleeding by the detection of alpha-fetoprotein (AFP) in vaginal blood
Mor A, Jubanyik K, Gardezi M, Nichols-Burns S, Zhang M, Esencan E, Simsek B, Seifer D, Taylor H. Prediction of pregnancy outcome in women with first trimester bleeding by the detection of alpha-fetoprotein (AFP) in vaginal blood. Fertility And Sterility 2019, 112: e312. DOI: 10.1016/j.fertnstert.2019.07.906.Peer-Reviewed Original ResearchRepeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques
Abdulhaqq S, Martinez M, Kang G, Rodriguez I, Nichols S, Beaumont D, Joseph J, Azzoni L, Yin X, Wise M, Weiner D, Liu Q, Foulkes A, Münch J, Kirchhoff F, Coutifaris C, Tomaras G, Sariol C, Marx P, Li Q, Kraiselburd E, Montaner L. Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques. Nature Communications 2019, 10: 3753. PMID: 31434895, PMCID: PMC6704120, DOI: 10.1038/s41467-019-11814-5.Peer-Reviewed Original ResearchConceptsCD4+ T cellsFemale reproductive tractSemen exposureT cellsIncreased infiltration of CD4+ T cellsMale-to-female HIV transmissionCirculating CD4+ T cellsInfiltration of CD4+ T cellsExposure to semenEffect of semenNon-human primatesExpression of Mx1Anti-HIV mechanismsCervicovaginal mucosaSIVmac251 challengeSIVmac251 infectionCCR5 expressionIn vivo evidenceHIV acquisitionHIV infectionHIV transmissionAssociated with activationIncreased infiltrationRhesus macaquesReproductive tract
2018
Analysis of a simulated liquid nitrogen storage tank failure
Kelk D, Liu Y, Nichols-Burns S, Lo J, Reed M, Pomeroy K. Analysis of a simulated liquid nitrogen storage tank failure. Fertility And Sterility 2018, 110: e18-e19. DOI: 10.1016/j.fertnstert.2018.07.069.Peer-Reviewed Original Research
2015
Comparison of Whole Ovary Cryotreatments for Fertility Preservation
Lotz L, Hauenstein T, Nichols-Burns S, Strissel P, Hoffmann I, Findeklee S, Dittrich R, Beckmann M, Oppelt P. Comparison of Whole Ovary Cryotreatments for Fertility Preservation. Reproduction In Domestic Animals 2015, 50: 958-964. PMID: 26446780, DOI: 10.1111/rda.12615.Peer-Reviewed Original ResearchConceptsWhole ovary cryopreservationWhole ovariesOvary cryopreservationSlow freezeFresh controlFertility preservationFollicle numberApoptotic folliclesHistological evaluationKrebs-RingerRadiotherapy treatmentPig ovariesOvariesSlow-freezing methodsSignificant differencesFunctional integrityFolliclesFurther investigationFresh tissueSpecimen jarOverall decreaseReproduktionsmedizin. Optimierte Transportbedingungen für konserviertes Ovarialgewebe
Lotz L, Schneider H, Nichols-Burns S, Hoffmann I, Oppelt P, Beckmann M, Dittrich R. Reproduktionsmedizin. Optimierte Transportbedingungen für konserviertes Ovarialgewebe. Geburtshilfe Und Frauenheilkunde 2015, 75: 218-221. DOI: 10.1055/s-0034-1396223.Peer-Reviewed Original Research
2014
Xenotransplantation of cryopreserved ovarian tissue: A realistic option for restoring fertility after cancer treatment?
Dittrich R, Lotz L, Nichols-Burns S, Scheider H, Hoffmann I, Hackl J, Beckmann M. Xenotransplantation of cryopreserved ovarian tissue: A realistic option for restoring fertility after cancer treatment? Geburtshilfe Und Frauenheilkunde 2014, 74 DOI: 10.1055/s-0034-1387957.Peer-Reviewed Original ResearchXenotransplantation of whole pig ovaries into nude rats as an experimental model for fertility preservation
Dittrich R, Lotz L, Nichols-Burns S, Schneider H, Hoffmann I, Beckmann M. Xenotransplantation of whole pig ovaries into nude rats as an experimental model for fertility preservation. Geburtshilfe Und Frauenheilkunde 2014, 74 DOI: 10.1055/s-0034-1388573.Peer-Reviewed Original ResearchSerial Cervicovaginal Exposures With Replication-Deficient SIVsm Induce Higher Dendritic Cell (pDC) and CD4+ T-Cell Infiltrates Not Associated With Prevention but a More Severe SIVmac251 Infection of Rhesus Macaques
Abdulhaqq S, Martinez M, Kang G, Foulkes A, Rodriguez I, Nichols S, Hunter M, Sariol C, Ruiz L, Ross B, Yin X, Speicher D, Haase A, Marx P, Li Q, Kraiselburd E, Montaner L. Serial Cervicovaginal Exposures With Replication-Deficient SIVsm Induce Higher Dendritic Cell (pDC) and CD4+ T-Cell Infiltrates Not Associated With Prevention but a More Severe SIVmac251 Infection of Rhesus Macaques. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 65: 405-413. PMID: 24226059, PMCID: PMC3943721, DOI: 10.1097/qai.0000000000000047.Peer-Reviewed Original ResearchConceptsPlasmacytoid dendritic cellsSimian immunodeficiency virusT cell infiltrationDendritic cellsCD4 T cell lossCD4+ T cell infiltrationPlasmacytoid dendritic cell recruitmentRate of CD4 declineInfection of rhesus macaquesCD4 T cell infiltrationRate of viral replicationT cell lossPlasma viral loadRhesus macaquesCD4 T cellsCD4 T lymphocytesImmune cell infiltrationIndian rhesus macaquesAssociated with preventionCD4 countVaginal exposureCD4 declineImmunodeficiency virusVaginal tissueT cells
2010
Recovery of Multiple Ovulation Products via Uterine Flushing of Superovulated Rhesus Macaques.
Nichols S, Gierbolini L, Gonzalez-Martinez J, Bavister B. Recovery of Multiple Ovulation Products via Uterine Flushing of Superovulated Rhesus Macaques. Biology Of Reproduction 2010, 83: 680-680. DOI: 10.1093/biolreprod/83.s1.680.Peer-Reviewed Original ResearchRhesus monkeysUnfertilized oocytesUterine flushingsRhesus macaquesEmbryonic stem cell linesStem cell linesSite of ovulationEarly embryo developmentRates of embryo recoveryCervical cannulationResponse to exogenous hormonesRodent modelsStandard in vivoHormonal profileMultiplication in vivoAssisted reproductionEmbryo characteristicsCell linesNon-human primatesRhesusEmbryo developmentEmbryo recoveryHuman reproductive issuesBlastocystUterine