2024
Beyond Earth’s bounds: navigating the frontiers of Assisted Reproductive Technologies (ART) in space
Chaplia O, Mathyk B, Nichols-Burns S, Basar M, Halicigil C. Beyond Earth’s bounds: navigating the frontiers of Assisted Reproductive Technologies (ART) in space. Reproductive Biology And Endocrinology 2024, 22: 123. PMID: 39394617, PMCID: PMC11468284, DOI: 10.1186/s12958-024-01290-y.Peer-Reviewed Original ResearchConceptsAssisted reproductive technologyIn vitro embryo developmentReproductive technologyRadiation-induced damageGamete handlingClinical embryologistsReproductive endocrinologistsTemperature limitEmbryo cultureReproductive medicineLow Earth orbitEmbryo developmentDeep space travelEarth orbitSpace environmentInterplanetary speciesEarth-boundMicrofluidic devicesCryopreservation
2021
Miscarriage determination in first trimester based on alpha-fetoprotein extracted from sanitary pads
Mor A, Gardezi M, Jubanyik K, Simsek B, Seifer DB, Patrizio P, Esencan E, Imamoglu G, Zhang M, Nichols-Burns SM, Taylor HS. Miscarriage determination in first trimester based on alpha-fetoprotein extracted from sanitary pads. Fertility And Sterility 2021, 116: 462-469. PMID: 33461753, DOI: 10.1016/j.fertnstert.2020.10.006.Peer-Reviewed Original ResearchConceptsExtrauterine pregnancyVaginal bloodAlpha-fetoproteinOngoing pregnancyAFP levelsSanitary padsHigh alpha-fetoprotein levelsOngoing pregnancy groupProspective cohort studyAlpha-fetoprotein levelsAcademic medical centerPregnancy groupCohort studyMiscarriage casesFirst trimesterOffice visitsMedical CenterMAIN OUTCOMEPregnancyMedian levelsMiscarriageBloodAnxiety levelsAFPCharacteristic analysis
2019
A step towards the automation of intracytoplasmic sperm injection: real time confirmation of mouse and human oocyte penetration and viability by electrical resistance measurement
Mor A, Zhang M, Esencan E, Simsek B, Nichols-Burns SM, Liu Y, Lo J, Kelk DA, Flores V, Gao XB, Seli E. A step towards the automation of intracytoplasmic sperm injection: real time confirmation of mouse and human oocyte penetration and viability by electrical resistance measurement. Fertility And Sterility 2019, 113: 234-236. PMID: 31883732, DOI: 10.1016/j.fertnstert.2019.09.023.Peer-Reviewed Original ResearchConceptsIntracytoplasmic sperm injectionICSI pipetteSperm injectionOocyte penetrationIntact oolemmaOocyte retrieval procedureMann-Whitney testMouse oocytesOocyte retrievalFemale miceMAIN OUTCOMEAcademic centersImmature oocytesHuman oocytesMature oocytesObjective toolMiceOocytesWomenVisual assessmentPipetteInjectionOolemmaStep 1GroupRepeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques
Abdulhaqq S, Martinez M, Kang G, Rodriguez I, Nichols S, Beaumont D, Joseph J, Azzoni L, Yin X, Wise M, Weiner D, Liu Q, Foulkes A, Münch J, Kirchhoff F, Coutifaris C, Tomaras G, Sariol C, Marx P, Li Q, Kraiselburd E, Montaner L. Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques. Nature Communications 2019, 10: 3753. PMID: 31434895, PMCID: PMC6704120, DOI: 10.1038/s41467-019-11814-5.Peer-Reviewed Original ResearchConceptsCD4+ T cellsFemale reproductive tractSemen exposureT cellsIncreased infiltration of CD4+ T cellsMale-to-female HIV transmissionCirculating CD4+ T cellsInfiltration of CD4+ T cellsExposure to semenEffect of semenNon-human primatesExpression of Mx1Anti-HIV mechanismsCervicovaginal mucosaSIVmac251 challengeSIVmac251 infectionCCR5 expressionIn vivo evidenceHIV acquisitionHIV infectionHIV transmissionAssociated with activationIncreased infiltrationRhesus macaquesReproductive tract
2009
Inner Cell Mass Localization of NANOG Precedes OCT3/4 in Rhesus Monkey Blastocysts
Harvey A, Armant D, Bavister B, Nichols S, Brenner C. Inner Cell Mass Localization of NANOG Precedes OCT3/4 in Rhesus Monkey Blastocysts. Stem Cells And Development 2009, 18: 1451-1458. PMID: 19537945, PMCID: PMC3016202, DOI: 10.1089/scd.2009.0122.Peer-Reviewed Original ResearchConceptsInner cell massInner cell masses of blastocystsRhesus monkey blastocystsOCT4 proteinExpression of CDX2Compacted morulaePig embryosBlastocystRegulatory markersOct4 expressionMouse embryosTrophectodermNanogNanog proteinCell massInvestigate local patternsPrimate developmentMiceRhesusMarkersExpressionLineage-specificEmbryosRegulatory mechanismsComplex interaction networks
2005
Ovarian senescence in the rhesus monkey (Macaca mulatta)
Nichols S, Bavister B, Brenner C, Didier P, Harrison R, Kubisch H. Ovarian senescence in the rhesus monkey (Macaca mulatta). Human Reproduction 2005, 20: 79-83. PMID: 15498779, PMCID: PMC4968694, DOI: 10.1093/humrep/deh576.Peer-Reviewed Original ResearchConceptsOvarian morphologyOvarian senescenceOld World primatesNumbers of primordial folliclesTime of menstrual cycleRhesus monkeysAge groupsWorld primatesPregnancy ratePrimordial folliclesMenstrual cycleFemales aged 1Primary folliclesStromal tissueAtretic folliclesReproductive ageReproductive senescenceMenopausal transitionAged 1FolliclesRhesusHuman femalesMacaca mulattaAgeOvary
2004
Non-human primates as a model for reproductive aging and human infertility.
Brenner C, Nichols S, Jacoby E, Bavister B. Non-human primates as a model for reproductive aging and human infertility. Gynecologic And Obstetric Investigation 2004, 57: 21-3. PMID: 14971419.Peer-Reviewed Original Research