2021
Miscarriage determination in first trimester based on alpha-fetoprotein extracted from sanitary pads
Mor A, Gardezi M, Jubanyik K, Simsek B, Seifer DB, Patrizio P, Esencan E, Imamoglu G, Zhang M, Nichols-Burns SM, Taylor HS. Miscarriage determination in first trimester based on alpha-fetoprotein extracted from sanitary pads. Fertility And Sterility 2021, 116: 462-469. PMID: 33461753, DOI: 10.1016/j.fertnstert.2020.10.006.Peer-Reviewed Original ResearchConceptsExtrauterine pregnancyVaginal bloodAlpha-fetoproteinOngoing pregnancyAFP levelsSanitary padsHigh alpha-fetoprotein levelsOngoing pregnancy groupProspective cohort studyAlpha-fetoprotein levelsAcademic medical centerPregnancy groupCohort studyMiscarriage casesFirst trimesterOffice visitsMedical CenterMAIN OUTCOMEPregnancyMedian levelsMiscarriageBloodAnxiety levelsAFPCharacteristic analysis
2019
Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques
Abdulhaqq S, Martinez M, Kang G, Rodriguez I, Nichols S, Beaumont D, Joseph J, Azzoni L, Yin X, Wise M, Weiner D, Liu Q, Foulkes A, Münch J, Kirchhoff F, Coutifaris C, Tomaras G, Sariol C, Marx P, Li Q, Kraiselburd E, Montaner L. Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques. Nature Communications 2019, 10: 3753. PMID: 31434895, PMCID: PMC6704120, DOI: 10.1038/s41467-019-11814-5.Peer-Reviewed Original ResearchConceptsCD4+ T cellsFemale reproductive tractSemen exposureT cellsIncreased infiltration of CD4+ T cellsMale-to-female HIV transmissionCirculating CD4+ T cellsInfiltration of CD4+ T cellsExposure to semenEffect of semenNon-human primatesExpression of Mx1Anti-HIV mechanismsCervicovaginal mucosaSIVmac251 challengeSIVmac251 infectionCCR5 expressionIn vivo evidenceHIV acquisitionHIV infectionHIV transmissionAssociated with activationIncreased infiltrationRhesus macaquesReproductive tract
2014
Serial Cervicovaginal Exposures With Replication-Deficient SIVsm Induce Higher Dendritic Cell (pDC) and CD4+ T-Cell Infiltrates Not Associated With Prevention but a More Severe SIVmac251 Infection of Rhesus Macaques
Abdulhaqq S, Martinez M, Kang G, Foulkes A, Rodriguez I, Nichols S, Hunter M, Sariol C, Ruiz L, Ross B, Yin X, Speicher D, Haase A, Marx P, Li Q, Kraiselburd E, Montaner L. Serial Cervicovaginal Exposures With Replication-Deficient SIVsm Induce Higher Dendritic Cell (pDC) and CD4+ T-Cell Infiltrates Not Associated With Prevention but a More Severe SIVmac251 Infection of Rhesus Macaques. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 65: 405-413. PMID: 24226059, PMCID: PMC3943721, DOI: 10.1097/qai.0000000000000047.Peer-Reviewed Original ResearchConceptsPlasmacytoid dendritic cellsSimian immunodeficiency virusT cell infiltrationDendritic cellsCD4 T cell lossCD4+ T cell infiltrationPlasmacytoid dendritic cell recruitmentRate of CD4 declineInfection of rhesus macaquesCD4 T cell infiltrationRate of viral replicationT cell lossPlasma viral loadRhesus macaquesCD4 T cellsCD4 T lymphocytesImmune cell infiltrationIndian rhesus macaquesAssociated with preventionCD4 countVaginal exposureCD4 declineImmunodeficiency virusVaginal tissueT cells