2024
Ezrin drives adaptation of monocytes to the inflamed lung microenvironment
Gudneppanavar R, Di Pietro C, H Öz H, Zhang P, Cheng E, Huang P, Tebaldi T, Biancon G, Halene S, Hoppe A, Kim C, Gonzalez A, Krause D, Egan M, Gupta N, Murray T, Bruscia E. Ezrin drives adaptation of monocytes to the inflamed lung microenvironment. Cell Death & Disease 2024, 15: 864. PMID: 39613751, PMCID: PMC11607083, DOI: 10.1038/s41419-024-07255-8.Peer-Reviewed Original ResearchConceptsActivation of focal adhesion kinaseExtracellular matrixActin-binding proteinsFocal adhesion kinaseLung extracellular matrixKnock-out mouse modelProtein kinase signalingCortical cytoskeletonLoss of ezrinKinase signalingPlasma membraneCell migrationSignaling pathwayEzrinResponse to lipopolysaccharideTissue-resident macrophagesMouse modelLipopolysaccharideCytoskeletonEzrin expressionLung microenvironmentKinaseMonocyte recruitmentProteinAkt
2010
Different Roles of G Protein Subunits β1 and β2 in Neutrophil Function Revealed by Gene Expression Silencing in Primary Mouse Neutrophils*
Zhang Y, Tang W, Jones MC, Xu W, Halene S, Wu D. Different Roles of G Protein Subunits β1 and β2 in Neutrophil Function Revealed by Gene Expression Silencing in Primary Mouse Neutrophils*. Journal Of Biological Chemistry 2010, 285: 24805-24814. PMID: 20525682, PMCID: PMC2915716, DOI: 10.1074/jbc.m110.142885.Peer-Reviewed Original ResearchConceptsGene expressionShort hairpin RNAPrimary mouse neutrophilsHairpin RNADirectional cell migrationFluorescent marker proteinsMouse neutrophilsMouse bone marrow cellsHost innate immunityDouble knockdownExcellent systemIngested bacteriaCell migrationMarker proteinsDivergent rolesKnockdownHematopoietic cellsHematopoietic systemBone marrow cellsSubunits β1Retroviral vectorsInnate immunityBacterial phagocytosisRNAExpression