Dorsal Striatal D2-Like Receptor Availability Covaries with Sensitivity to Positive Reinforcement during Discrimination Learning
Groman SM, Lee B, London ED, Mandelkern MA, James AS, Feiler K, Rivera R, Dahlbom M, Sossi V, Vandervoort E, Jentsch JD. Dorsal Striatal D2-Like Receptor Availability Covaries with Sensitivity to Positive Reinforcement during Discrimination Learning. Journal Of Neuroscience 2011, 31: 7291-7299. PMID: 21593313, PMCID: PMC3114883, DOI: 10.1523/jneurosci.0363-11.2011.Peer-Reviewed Original ResearchConceptsLike receptor availabilityIndividual differencesDiscrimination learningBehavioral flexibilitySpecific neurocognitive mechanismsVisual discrimination problemsBehavioral sensitivityReceptor availabilityNeurocognitive mechanismsReward sensitivityBehavioral performanceNeural mechanismsVisual discriminationNeuropsychiatric disordersPositive reinforcementReversal phaseEnvironmental contingenciesThree-choiceNumber of trialsPhenotypic dimensionsPsychiatric conditionsFeedback sensitivityLearningElectrophysiological findingsDisorders