Stephanie Eisenbarth, MD, PhD
Associate Professor AdjunctDownloadHi-Res Photo
Cards
Appointments
Laboratory Medicine
Primary
Immunobiology
Secondary
Contact Info
Laboratory Medicine
789 Howard Avenue, Clinic Building
New Haven, CT 06520
United States
About
Titles
Associate Professor Adjunct
Biography
Dr. Eisenbarth’s laboratory focuses on how dendritic cells, B cells and T cells interact to induce tailored adaptive immune responses. The work spans how this triad is operational in the spleen to transfused red blood cells (RBCs), in the lung to aeroallergens, and in the gut to food allergens, utilizing both mouse models and human samples.
Appointments
Laboratory Medicine
Associate Professor AdjunctPrimaryImmunobiology
Associate Professor on TermSecondary
Other Departments & Organizations
- Diabetes Research Center
- Immunobiology
- Laboratory Medicine
- Yale Stem Cell Center
- Yale Ventures
Education & Training
- Postdoctoral Fellow
- Yale University (2010)
- Resident
- Yale New Haven Hospital (2008)
- MD
- Yale School of Medicine (2005)
- PhD
- Yale University (2003)
- BA
- Bryn Mawr College (1996)
Research
Overview
Medical Research Interests
Allergy and Immunology; Asthma; Blood Group Incompatibility; Food Hypersensitivity; Immune System Diseases
ORCID
0000-0002-1244-208X- View Lab Website
Eisenbarth Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Stephanie Eisenbarth's published research.
Elise Liu, MD, PhD
Xiangyun Yin
Laura Rose Hoyt
Michael Caplan, PhD, MD
Shuting Chen
Veronika Shabanova, PhD
Publications
2024
Dendritic cells in a pinch: Migration during homeostasis.
Olson E, Eisenbarth S. Dendritic cells in a pinch: Migration during homeostasis. Science Immunology 2024, 9: eadt3806. PMID: 39365873, DOI: 10.1126/sciimmunol.adt3806.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsDendritic cellsScaleable production of highly loaded protein nanoparticles for immune modulation
Caplan M, Baldwin R, Yin X, Grishin A, Eisenbarth S, Sampson H, Bottomly K, Prud’homme R. Scaleable production of highly loaded protein nanoparticles for immune modulation. Communications Materials 2024, 5: 191. DOI: 10.1038/s43246-024-00626-w.Peer-Reviewed Original ResearchConceptsAdjuvants to antigen-presenting cellsImmune modulationAntigen-presenting cellsMurine immune systemImmune system cellsPeanut-allergic patientsDesensitizer applicationPLG nanoparticlesAntigen deliverySystemic exposurePoly(lactide-co-glycolideBasophil activationClinical investigationAllergic responsesImmune systemSystem cellsProtein antigensClinical applicationDelivery of proteinsE. coli phospholipidsSafety evidenceAntigenProtein nanoparticlesDeliveryCellsAll roads lead to IgA: Mapping the many pathways of IgA induction in the gut
Siniscalco E, Williams A, Eisenbarth S. All roads lead to IgA: Mapping the many pathways of IgA induction in the gut. Immunological Reviews 2024, 326: 66-82. PMID: 39046160, DOI: 10.1111/imr.13369.Peer-Reviewed Original ResearchConceptsIgA inductionFood allergyFood-specific IgE.Food-specific IgEAntibody isotypesPrevalence of food allergyT cell helpIncreasing prevalence of food allergyRelease of histamineFoodFood antigensB cellsInduce toleranceAdverse reactionsCommensal bacteriaMast cellsIncreased prevalenceGut immunityIgAGutAllergyAntibodiesIsotypeInductionHuman red blood cells express the RNA sensor TLR7
Metthew Lam L, Oatman E, Eckart K, Klingensmith N, Flowers E, Sayegh L, Yuen J, Clements R, Meyer N, Jurado K, Vaughan A, Eisenbarth S, Mangalmurti N. Human red blood cells express the RNA sensor TLR7. Scientific Reports 2024, 14: 15789. PMID: 38982195, PMCID: PMC11233670, DOI: 10.1038/s41598-024-66410-5.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsDendritic cells in food allergy, treatment, and tolerance
Liu E, Yin X, Siniscalco E, Eisenbarth S. Dendritic cells in food allergy, treatment, and tolerance. Journal Of Allergy And Clinical Immunology 2024, 154: 511-522. PMID: 38971539, PMCID: PMC11414995, DOI: 10.1016/j.jaci.2024.06.017.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAntigen presenting cellsDendritic cellsFood allergyOral tolerancePresenting cellsAllergic sensitizationPeripheral T regulatory cellsDevelopment of oral toleranceGut dendritic cellsT regulatory cellsDendritic cell subsetsLimited treatment optionsAdaptive immune responsesFood immunotherapyEpicutaneous immunotherapyCell subsetsTolerogenic programAlarmin releaseTreatment optionsLangerhans cellsFood toleranceInnocuous antigensSurface markersInflammatory conditionsImmune responseDefining and targeting mechanisms of eosinophilic inflammation in a new era of severe asthma treatment
Boyce J, Eisenbarth S. Defining and targeting mechanisms of eosinophilic inflammation in a new era of severe asthma treatment. Journal Of Clinical Investigation 2024, 134: e182410. PMCID: PMC11178525, DOI: 10.1172/jci182410.Peer-Reviewed Original ResearchCitationsAltmetricThe aMPPle differentiation potential of TH2 cells in human allergy.
Siddapureddy S, Eisenbarth S. The aMPPle differentiation potential of TH2 cells in human allergy. Science Immunology 2024, 9: eadq7287. PMID: 38848341, DOI: 10.1126/sciimmunol.adq7287.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsDOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells.
Williams A, Siniscalco E, Grassmann J, Craft J, Eisenbarth S, Uthaman G. DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells. The Journal Of Immunology 2024, 212: 0620_4120-0620_4120. DOI: 10.4049/jimmunol.212.supp.0620.4120.Peer-Reviewed Original ResearchConceptsPeanut-specific IgET cellsSpecific IgEFood allergyT follicular helper cellsCD4+ T cellsDOCK8-deficient patientsFood-specific IgEPeanut-specific IgE.Human T cellsCells in vitroDifferentiation in vivoSevere food allergyTfh cellsRegulatory populationsOvercome toleranceHelper cellsDeficient patientsSpecific IgE.DOCK8IgE productionSTAT3 mutationsMiceCholera toxinIgEFood Matrix Composition Affects the Allergenicity of Baked Egg Products
Liu E, Tan J, Munoz J, Shabanova V, Eisenbarth S, Leeds S. Food Matrix Composition Affects the Allergenicity of Baked Egg Products. The Journal Of Allergy And Clinical Immunology In Practice 2024, 12: 2111-2117. PMID: 38670261, DOI: 10.1016/j.jaip.2024.04.032.Peer-Reviewed Original ResearchConceptsEgg allergensEgg productionFood matricesExtract ovalbuminFood matrix compositionAllergenicity of eggBaked eggMuffin recipeQuantify ovalbuminRice muffinsRice flourWheat flourBlocking ELISAWheat muffinsFood ingredientsMuffinsHeated eggEgg proteinsEgg-allergic patientsWheatEggsFood allergic reactionsReduced allergenicityFlourFoodIn a wild germinal center, what determines survival of the fittest?
Flowers E, Eisenbarth S. In a wild germinal center, what determines survival of the fittest? Science Immunology 2024, 9: eadn7535. PMID: 38181096, DOI: 10.1126/sciimmunol.adn7535.Peer-Reviewed Original ResearchAltmetricMeSH Keywords
Academic Achievements & Community Involvement
activity American Society for Clinical Investigation
Professional OrganizationsMemberDetails04/17/2020 - Present
News & Links
Media
News
- February 26, 2024
Elise Liu Receives 2024 AAAAI Foundation Faculty Development Award
- May 08, 2023
Liu Wins ASCI Emerging-Generation Award
- October 28, 2022
Meet Yale Allergy & Immunology: Jake Kuster, MD, and Elise Liu, MD
- June 08, 2022Source: Current Biology
A group approach to growing as a principal investigator
Related Links
Get In Touch
Contacts
Academic Office Number
Lab Number
Mailing Address
Laboratory Medicine
789 Howard Avenue, Clinic Building
New Haven, CT 06520
United States
Administrative Support
Locations
Clinic Building
Academic Office
789 Howard Avenue, Ste CB 407
New Haven, CT 06519
Appointments
203.737.4188