2024
Dehydration and Suboptimal Sleep Aggravate Early Renal Impairment in Children: Longitudinal Findings from the PROC Study
Li M, Xiao H, Amaerjiang N, Thapa B, Shu W, Asihaer Y, Guan M, Vermund S, Zou Z, Huang D, Hu Y. Dehydration and Suboptimal Sleep Aggravate Early Renal Impairment in Children: Longitudinal Findings from the PROC Study. Nutrients 2024, 16: 3472. PMID: 39458467, PMCID: PMC11510355, DOI: 10.3390/nu16203472.Peer-Reviewed Original ResearchConceptsTransient renal impairmentRenal impairmentSystolic blood pressure z-scoreBody mass index z-scoreLong sleepBlood pressure z-scoreZ-scoreEarly renal impairmentOptimal sleepAssessment of sleep durationHealthy primary school childrenShort sleepMediterranean diet adherenceHydration statusAssociation of sleep durationSleep durationKidney healthMixed-effects modelsLinear mixed-effects modelsAssess longitudinal associationsMicroalbumin excretionGlomerular impairmentCohort studyDiet adherenceScreen timeAssessment of a screening tool to aid home-based identification of adolescents (aged 10–14) living with HIV in Zambia and South Africa: HPTN 071 (PopART) study
Chaila M, Mcleod D, Vermund S, Mbolongwe-Thornicroft M, Mbewe M, Mubekapi-Musadaidzwa C, Harper A, Schaap A, Floyd S, Hoddinott G, Hayes R, Fidler S, Ayles H, Shanaube K, Team O. Assessment of a screening tool to aid home-based identification of adolescents (aged 10–14) living with HIV in Zambia and South Africa: HPTN 071 (PopART) study. PLOS ONE 2024, 19: e0266573. PMID: 38363733, PMCID: PMC10871489, DOI: 10.1371/journal.pone.0266573.Peer-Reviewed Original ResearchConceptsScreening toolUniversal testingCommunity HIV-care providersCombination HIV prevention packageHIV-care providersHIV-positiveHIV prevention packageRapid HIV testingHIV test resultsRapid HIV test resultsHistory of hospital admissionIdentification of adolescentsPopART interventionUndiagnosed HIVHIV testingPrevention packageDoor-to-doorPoor healthHIV interventionsCommunity settingsConsented adolescentsHospital admissionSelf-reportSouth AfricaPopART
2023
Sex-Specific Differences in Left Ventricular Mass and Volumes with Body Mass Index among Children Aged 6 to 8: A Cross-Sectional Study in China
Xiao H, Shu W, Li M, Xu L, Amaerjiang N, Zunong J, Vermund S, Huang D, Chong M, Hu Y. Sex-Specific Differences in Left Ventricular Mass and Volumes with Body Mass Index among Children Aged 6 to 8: A Cross-Sectional Study in China. Nutrients 2023, 15: 3066. PMID: 37447393, PMCID: PMC10347080, DOI: 10.3390/nu15133066.Peer-Reviewed Original ResearchConceptsBody mass indexLeft ventricular massVisceral fat areaHigher body mass indexBlood pressureWaist circumferenceMass indexVentricular massStroke volumeFat massElevated body mass indexHigher left ventricular massVentricle end-diastolic volumeGreater LV hypertrophyCardiovascular risk factorsSex differencesDiastolic blood pressureSystolic blood pressureOverweight/obesityLeft ventricle structureEnd-diastolic volumeEnd-systolic volumeCross-sectional studyChildren Aged 6LV hypertrophyValidation of “Life's Essential 8” Metrics With Cardiovascular Structural Status in Children: The PROC Study in China
Shu W, Li M, Xiao H, Amaerjiang N, Khattab N, Zunong J, Guan M, Vermund S, Hu Y. Validation of “Life's Essential 8” Metrics With Cardiovascular Structural Status in Children: The PROC Study in China. Journal Of The American Heart Association 2023, 12: e029077. PMID: 37301752, PMCID: PMC10356051, DOI: 10.1161/jaha.122.029077.Peer-Reviewed Original ResearchConceptsCarotid intima-media thicknessIntima-media thicknessCVH scoreCardiovascular healthLVM indexAbnormal sleep durationChildren's cardiovascular healthOverweight/obesityMin/wkWorse cardiovascular healthChild Cohort StudyM-mode echocardiographyAge/sexLower CVH scoreFollow-up (12- and 24-month) assessmentLipid scoreNormal BPCohort studyFasting GlucosePrimordial preventionNicotine exposureVentricular massPhysical activitySleep durationUS population
2022
Interplay of Lymphocytes with the Intestinal Microbiota in Children with Nonalcoholic Fatty Liver Disease
Liang T, Li D, Zunong J, Li M, Amaerjiang N, Xiao H, Khattab N, Vermund S, Hu Y. Interplay of Lymphocytes with the Intestinal Microbiota in Children with Nonalcoholic Fatty Liver Disease. Nutrients 2022, 14: 4641. PMID: 36364902, PMCID: PMC9657134, DOI: 10.3390/nu14214641.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseFatty liver diseaseHigher lymphocyte countsLymphocyte countGut microbiotaLiver diseaseHealthy childrenGut microbiota dysbiosisEffect of lymphocytesProinflammatory bacteriaMicrobiota dysbiosisRisk factorsIntestinal microbiotaAbundance of BacteroidetesLymphocytesMicrobiotaChildrenOpportunistic pathogenDiseaseCountMetagenomic sequencingLow numberHigher numberDysbiosisGroupPassive Smoking Exposure Modifies Cardiovascular Structure and Function: Beijing Child Growth and Health Cohort (PROC) Study
Xiao H, Li M, Li A, Amaerjiang N, Zunong J, Vermund SH, Pérez-Escamilla R, Song M, Hu Y, Jiang G. Passive Smoking Exposure Modifies Cardiovascular Structure and Function: Beijing Child Growth and Health Cohort (PROC) Study. Environmental Science And Technology 2022, 56: 14585-14593. PMID: 36094430, DOI: 10.1021/acs.est.2c00991.Peer-Reviewed Original ResearchConceptsVentricular mass indexSecondhand smokeCardiovascular healthSHS exposureMass indexLow left ventricular mass indexVentricular end-diastolic volume indexVentricular end-systolic volume indexEnd-diastolic volume indexEnd-systolic volume indexLeft ventricular mass indexVentricular end-systolic diameterVolume indexChildren's cardiovascular healthPassive smoking exposureSystolic volume indexEnd-systolic diameterHealth Cohort StudyDiastolic volume indexInterventricular septum thicknessSystemic toxinsSmoking exposureCohort studySystolic diameterAorta diameterInsufficient Fruit and Vegetable Intake and Low Potassium Intake Aggravate Early Renal Damage in Children: A Longitudinal Study
Li M, Amaerjiang N, Li Z, Xiao H, Zunong J, Gao L, Vermund SH, Hu Y. Insufficient Fruit and Vegetable Intake and Low Potassium Intake Aggravate Early Renal Damage in Children: A Longitudinal Study. Nutrients 2022, 14: 1228. PMID: 35334885, PMCID: PMC8951514, DOI: 10.3390/nu14061228.Peer-Reviewed Original ResearchConceptsEarly renal damageDaily potassium intakePotassium intakeRenal damageMA excretionVegetable intakeInsufficient fruitΒ2-MGSleep durationScreen timeHigh β2-MGUrinary MA excretionUrinary β2-MGGeneral pediatric populationLow potassium intakeChild Cohort StudyShort sleep durationNon-communicable diseasesLonger screen timeMicroalbumin excretionCohort studyUrinary potassiumPediatric populationPhysical activityLifestyle statusSchool closures and reopenings during the COVID-19 pandemic: a scoping review protocol
Li D, Nyhan K, Zhou X, Zhu Y, Castro D, Vermund SH, Brault M. School closures and reopenings during the COVID-19 pandemic: a scoping review protocol. BMJ Open 2022, 12: e054292. PMID: 35110320, PMCID: PMC8811274, DOI: 10.1136/bmjopen-2021-054292.Peer-Reviewed Original ResearchConceptsSchool closuresCOVID-19 pandemicWidespread school closuresCitation chainingType of researchSchool safetySchool reopeningSchoolsIndependent third reviewerPaucity of researchCollege studentsSources of evidenceJoanna Briggs Institute methodologyIndividual knowledgePandemicTitle screeningIndividual concernsCOVID-19 evidenceDisease prevention practicesGrey literatureFormal ethical approvalFull-text screeningBroad disseminationTeachersReopeningDehydration Status Aggravates Early Renal Impairment in Children: A Longitudinal Study
Amaerjiang N, Li M, Xiao H, Zunong J, Li Z, Huang D, Vermund SH, Pérez-Escamilla R, Jiang X, Hu Y. Dehydration Status Aggravates Early Renal Impairment in Children: A Longitudinal Study. Nutrients 2022, 14: 335. PMID: 35057516, PMCID: PMC8778530, DOI: 10.3390/nu14020335.Peer-Reviewed Original ResearchConceptsRenal function impairmentEuhydrated groupRenal impairmentUrine specific gravityDehydration statusDehydrated groupFunction impairmentSchool weekdaysHydration statusPrevalence of dehydrationLongitudinal studyMixed-effects regression modelsChi-square testTubular abnormalitiesMean ageChild CohortMicroalbuminImpairmentDifferent hydration statusChildrenWeeksRegression modelsStatusGroupSchool day
2021
Predictors of non-alcoholic fatty liver disease in children
Li M, Shu W, Zunong J, Amaerjiang N, Xiao H, Li D, Vermund SH, Hu Y. Predictors of non-alcoholic fatty liver disease in children. Pediatric Research 2021, 92: 322-330. PMID: 34580427, DOI: 10.1038/s41390-021-01754-6.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseasePediatric non-alcoholic fatty liver diseaseAbdominal obesity indicatorsFatty liver diseaseBody composition indicatorsLiver diseaseObesity indicatorsDiscriminative performancePopulation-based child cohortClinical Trials RegistryOptimal screening toolComposition indicatorsCurve valuesTrials RegistryLiver damageWeight managementChild CohortAnthropometric indicatorsEarly identificationLogistic regressionEndocrine indicatorsScreening toolDiseaseSpearman correlationCharacteristic curveWhere Should Orphaned and Separated Children and Adolescents Live: Comparing Institutionalized- and Family-Based Venues in Kenya
Vermund SH. Where Should Orphaned and Separated Children and Adolescents Live: Comparing Institutionalized- and Family-Based Venues in Kenya. JAMA Network Open 2021, 4: e2125572. PMID: 34529069, PMCID: PMC10773959, DOI: 10.1001/jamanetworkopen.2021.25572.Peer-Reviewed Original ResearchUnderstanding HIV outbreak among children in a rural community of Sindh province of Pakistan.
Altaf A, Shah SA, Khanani R, Vermund SH. Understanding HIV outbreak among children in a rural community of Sindh province of Pakistan. Journal Of The Pakistan Medical Association 2021, 71(Suppl 4): s1-s4. PMID: 34469421, PMCID: PMC10768810.Peer-Reviewed Original ResearchReopening Schools After a Novel Coronavirus Surge
Li D, Lin EZ, Brault MA, Paquette J, Vermund SH, Godri Pollitt KJ. Reopening Schools After a Novel Coronavirus Surge. Advances In Experimental Medicine And Biology 2021, 1318: 785-813. PMID: 33973212, DOI: 10.1007/978-3-030-63761-3_44.Peer-Reviewed Original ResearchConceptsCoronavirus disease 2019 (COVID-19) pandemicDisease 2019 pandemicGlobal death tollMental health supportPandemic influenzaDisease controlHealth supportSocial isolationNew guidelinesVulnerability of childrenRisk reductionRiskDisease control strategiesSafetyChild safetySpecial considerationDeath tollOpening schoolsPandemic
2020
Measuring child survival for the Millennium Development Goals in Africa: what have we learned and what more is needed to evaluate the Sustainable Development Goals?
Brault MA, Mwinga K, Kipp AM, Kennedy SB, Maimbolwa M, Moyo P, Ngure K, Haley CA, Vermund SH. Measuring child survival for the Millennium Development Goals in Africa: what have we learned and what more is needed to evaluate the Sustainable Development Goals? Global Health Action 2020, 13: 1732668. PMID: 32114967, PMCID: PMC7067162, DOI: 10.1080/16549716.2020.1732668.Peer-Reviewed Original ResearchConceptsSustainable Development Goal periodMillennium Development GoalsDevelopment GoalsGoal periodAreas of governanceMillennium Development Goal periodKey global health challengeSustainable Development GoalsChild mortalityCountry‐specific goalsQualitative data collectionPolicy documentsNational contextsRegion nationsCountries—KenyaQualitative interviewsSub-Saharan AfricaMethodological opportunitiesInternational goalsFamiliar themesValuable lessonsCountriesCase studyChild survivalQuantitative indicators
2019
Attrition of HIV-positive children from HIV services in low and middle-income countries.
Carlucci JG, Liu Y, Clouse K, Vermund SH. Attrition of HIV-positive children from HIV services in low and middle-income countries. AIDS 2019, 33: 2375-2386. PMID: 31764102, PMCID: PMC6905128, DOI: 10.1097/qad.0000000000002366.Peer-Reviewed Original ResearchConceptsHIV-positive childrenHIV servicesAntiretroviral therapyMiddle-income countriesEarly ART initiationPatient support servicesOptimal health outcomesMeta-regression analysisART initiationLTFU definitionStudy eligibilityMagnitude of attritionEligibility criteriaHealth outcomesSystematic reviewRandom-effects meta-analytic methodsOverall attritionMeta-analytic methodsMultidatabase searchData extractionVulnerable populationsImplementation researchMonthsMost attritionLTFUPromoting progress in child survival across four African countries: the role of strong health governance and leadership in maternal, neonatal and child health
Haley CA, Brault MA, Mwinga K, Desta T, Ngure K, Kennedy SB, Maimbolwa M, Moyo P, Vermund SH, Kipp AM, Kabaka S, Sergon K, Clarke A, Duworko M, Kalesha-Masumbu P, Katepa-Bwalya M, Madzima B, Kanyowa T, Habimana P. Promoting progress in child survival across four African countries: the role of strong health governance and leadership in maternal, neonatal and child health. Health Policy And Planning 2019, 34: 24-36. PMID: 30698696, PMCID: PMC6479825, DOI: 10.1093/heapol/czy105.Peer-Reviewed Original ResearchConceptsChild survivalChild mortalityChild healthWorld Health Organization (WHO) African RegionCoordination of servicesSaharan AfricaHealth governanceMortalityDevelopment GoalsCurrent sustainable development goalsStudy countriesSurvivalMNCHPace of reductionTwo-thirdsHealth leadershipSustainable Development GoalsMillennium Development GoalsCross-country analysisAfrican regionFour-country studyTop national priorityHealthSufficient humanIndividual case studies
2017
Monitoring Anesthesia Care Delivery and Perioperative Mortality in Kenya Utilizing a Provider-driven Novel Data Collection Tool
Sileshi B, Newton MW, Kiptanui J, Shotwell MS, Wanderer JP, Mungai M, Scherdin J, Harris PA, Vermund SH, Sandberg WS, McEvoy MD. Monitoring Anesthesia Care Delivery and Perioperative Mortality in Kenya Utilizing a Provider-driven Novel Data Collection Tool. Anesthesiology 2017, 127: 250-271. PMID: 28657959, PMCID: PMC5519082, DOI: 10.1097/aln.0000000000001713.Peer-Reviewed Original ResearchConceptsPerioperative dataPerioperative mortality rateTertiary referral hospitalMortality rate differencesAnesthesia care deliveryLogistic regression modelsMiddle-income settingsPerioperative mortalityCesarean deliveryEmergency surgeryMiddle-income countriesPerioperative careReferral hospitalSurgery typeSingle centerProcedure typeGeneral surgeryHigh riskMortality rateCare deliveryMortalityData collection periodData collection toolSurgeryRegression modelsMortality in Children with Human Immunodeficiency Virus Initiating Treatment: A Six-Cohort Study in Latin America
Luque MT, Jenkins CA, Shepherd BE, Padgett D, Rouzier V, Succi RCM, Machado DM, McGowan CC, Vermund SH, Pinto JA. Mortality in Children with Human Immunodeficiency Virus Initiating Treatment: A Six-Cohort Study in Latin America. The Journal Of Pediatrics 2017, 182: 245-252.e1. PMID: 28081884, PMCID: PMC5328796, DOI: 10.1016/j.jpeds.2016.12.034.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCause of DeathChildChild, PreschoolCohort StudiesConfidence IntervalsDatabases, FactualDose-Response Relationship, DrugDrug Administration ScheduleFemaleHIV InfectionsHumansIncidenceLatin AmericaMaleProportional Hazards ModelsRetrospective StudiesRisk AssessmentSeverity of Illness IndexSurvival AnalysisConceptsCombination antiretroviral therapyYears of ageCART initiationGreater riskCox proportional hazards modelAntiretroviral therapy-naïveMedian CD4 countRetrospective cohort studyProportional hazards modelCumulative mortality incidenceSouth America networkProbability of deathInitiating treatmentMedian CD4Antiretroviral therapyCause mortalityCD4 countTherapy-naïveCohort studyCumulative incidenceHIV epidemiologyPediatric careMortality incidenceHazards modelRegimens
2016
Factors associated with declining under-five mortality rates from 2000 to 2013: an ecological analysis of 46 African countries
Kipp AM, Blevins M, Haley CA, Mwinga K, Habimana P, Shepherd BE, Aliyu MH, Ketsela T, Vermund SH. Factors associated with declining under-five mortality rates from 2000 to 2013: an ecological analysis of 46 African countries. BMJ Open 2016, 6: e007675. PMID: 26747029, PMCID: PMC4716228, DOI: 10.1136/bmjopen-2015-007675.Peer-Reviewed Original ResearchMeSH KeywordsAfricaBirth RateChildChild HealthChild MortalityDeveloping CountriesEconomic DevelopmentHealth ExpendituresHealth PolicyHealth ServicesHealthcare FinancingHumansInfantInfant HealthInfant MortalityMaternal HealthMaternal MortalityPatient Acceptance of Health CareSocial Determinants of HealthSocioeconomic FactorsTechnologyConceptsMortality rateAcute respiratory infectionsChild health interventionsMaternal mortality ratioU5M rateHigh ARRRespiratory infectionsPotential confoundersMaternal healthMortality ratioHealth interventionsSignificant associationAnnual rateMajority of factorsRobust linear regression modelsStudy periodM rateHealth expenditureLinear regression modelsARRTwo-thirdsRegression modelsAssociationHealthAfrican countries
2015
Wheezing Is Common in Children With Sickle Cell Disease When Compared With Controls
Galadanci NA, Liang WH, Galadanci AA, Aliyu MH, Jibir BW, Karaye IM, Inusa BP, Vermund SH, Strunk RC, DeBaun MR. Wheezing Is Common in Children With Sickle Cell Disease When Compared With Controls. Journal Of Pediatric Hematology/Oncology 2015, 37: 16-19. PMID: 25197776, PMCID: PMC4866494, DOI: 10.1097/mph.0000000000000239.Peer-Reviewed Original ResearchConceptsSickle cell diseaseCell diseaseAmerican Thoracic Society DivisionLung Disease QuestionnaireAbsence of asthmaCase-control study designTimes greater oddsHigh rateDisease QuestionnaireRespiratory symptomsMedian ageCommunity hospitalMultivariable modelGreater oddsSCD experienceSCD statusStudy designOnly variableSimilar ageChildrenParent reportDiseaseAgeSame settingQuestionnaire