2003
CC Chemokine Receptor 5 Genotype and Susceptibility to Transmission of Human Immunodeficiency Virus Type 1 in Women
Philpott S, Weiser B, Tarwater P, Vermund SH, Kleeberger CA, Gange SJ, Anastos K, Cohen M, Greenblatt RM, Kovacs A, Minkoff H, Young MA, Miotti P, Dupuis M, Chen CH, Burger H. CC Chemokine Receptor 5 Genotype and Susceptibility to Transmission of Human Immunodeficiency Virus Type 1 in Women. The Journal Of Infectious Diseases 2003, 187: 569-575. PMID: 12599073, PMCID: PMC3319124, DOI: 10.1086/367995.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesDisease Transmission, InfectiousFemaleGene DeletionGene FrequencyGenetic Predisposition to DiseaseHeterozygoteHIV InfectionsHIV SeropositivityHIV-1HumansReceptors, CCR5United StatesUrban PopulationConceptsHuman immunodeficiency virus type 1Immunodeficiency virus type 1Virus type 1HIV-1-seronegative womenHIV-1-seropositive womenDelta 32Women's Interagency HIV StudyType 1CC chemokine receptor 5HIV-1 transmissionHIV-1 infectionChemokine receptor 5Differential genetic susceptibilityHeterosexual spreadHIV StudyHIV-1Receptor 5Male cohortGenetic susceptibilityPartial protectionWomenBehavioral factorsInfectionHeterozygous genotypeMost studies
2002
Host genetic profiles predict virological and immunological control of HIV-1 infection in adolescents
Tang J, Wilson CM, Meleth S, Myracle A, Lobashevsky E, Mulligan MJ, Douglas SD, Korber B, Vermund SH, Kaslow RA. Host genetic profiles predict virological and immunological control of HIV-1 infection in adolescents. AIDS 2002, 16: 2275-2284. PMID: 12441799, DOI: 10.1097/00002030-200211220-00007.Peer-Reviewed Original ResearchConceptsViral loadHLA class IHost genetic profileHIV-1-infected adolescentsHIV-1-seropositive participantsCD4 T-cell countClass IHIV-seronegative individualsT-cell countsCD4 T lymphocytesHIV-1 infectionHIV-1 pathogenesisGenetic profileClinical patient groupsAntiretroviral therapyQuarterly followMultivariable analysisHealth cohortPatient groupImmunological outcomesImmunological controlNegative HLAT lymphocytesProtective effectAdolescent care