2013
Impact of HIV drug resistance on virologic and immunologic failure and mortality in a cohort of patients on antiretroviral therapy in China
Liao L, Xing H, Su B, Wang Z, Ruan Y, Wang X, Liu Z, Lu Y, Yang S, Zhao Q, Vermund SH, Chen RY, Shao Y. Impact of HIV drug resistance on virologic and immunologic failure and mortality in a cohort of patients on antiretroviral therapy in China. AIDS 2013, 27: 1815-1824. PMID: 23803794, PMCID: PMC3694318, DOI: 10.1097/qad.0b013e3283611931.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyHIV drug resistanceImmunologic failureHigh mortalityVirologic failureAntiretroviral therapyEmergence of HIVDRBaseline CD4 cell countDrug resistanceCD4 cell countCohort of patientsSecond-line drugsEnd of studyProportional hazards modelRural Chinese countiesHIVDR mutationsMedian timePatient adherenceKaplan-MeierChinese patientsRisk factorsHazards modelPatientsCell countMortality
2007
Early clinical and immune response to NNRTI-based antiretroviral therapy among women with prior exposure to single-dose nevirapine
Chi BH, Sinkala M, Stringer EM, Cantrell RA, Mtonga V, Bulterys M, Zulu I, Kankasa C, Wilfert C, Weidle PJ, Vermund SH, Stringer J. Early clinical and immune response to NNRTI-based antiretroviral therapy among women with prior exposure to single-dose nevirapine. AIDS 2007, 21: 957-964. PMID: 17457089, PMCID: PMC2745970, DOI: 10.1097/qad.0b013e32810996b2.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountDrug Administration ScheduleEpidemiologic MethodsFemaleHIV InfectionsHumansInfectious Disease Transmission, VerticalNevirapinePregnancyPregnancy Complications, InfectiousReverse Transcriptase InhibitorsTreatment FailureTreatment OutcomeConceptsSingle-dose nevirapineClinical treatment failureCD4 cell responseAntiretroviral therapyTreatment failureNVP exposureTreatment outcomesCell responsesShort-term treatment outcomesPrior exposureChild HIV transmissionPrevention of motherCD4 cell changesPoor treatment outcomesNon-nucleoside reverseSignificant differencesWorld Health Organization guidelinesHealth Organization guidelinesART initiationCohort evaluationMultivariable analysisHIV transmissionHIV treatmentRisk factorsImmune response
2002
Lack of Effect of Chlorhexidine Varnish on Streptococcus mutans Transmission and Caries in Mothers and Children
Dasanayake AP, Wiener HW, Li Y, Vermund S, Caufield PW. Lack of Effect of Chlorhexidine Varnish on Streptococcus mutans Transmission and Caries in Mothers and Children. Caries Research 2002, 36: 288-293. PMID: 12218279, DOI: 10.1159/000063922.Peer-Reviewed Original ResearchConceptsChlorhexidine varnishSalivary S. mutans levelsChild's fourth birthdayRandomized clinical trialsS. mutans levelsMother-child pairsFourth birthdayMother-child transmissionS. mutans colonizationLack of effectCaries experienceMutans levelsPlacebo varnishClinical trialsFirst babyTreatment groupsControl groupWeekly intervalsCariesMothersChildrenMonthsStreptococcus mutansGroupBabies